NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1300-73-8
Chemical Name	Xylidine
Substance ID	m-nite-1300-73-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Flash point: >93degC	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine and chlorine.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There was no report as an isomer mixture. But rats of each isomer and LD50 value were within the limits of 470mg/kg to 1270 kg/kg, it was classified into Category 4.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	It was classified into Category 4 since there were description of rat LD50: 2000mg/kg and rabbit LD50: 1500mg/kg (DFGOTvol.19 (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	There is no report of an isomer mixture. There is a data of mouse LC50: 149ppm/7h for 2, 4-Xylidine (ACGIH (2002)). The saturated vapor concentration at 25degC is 180ppm (0.89mg/L), and it is thought that LC50 value in this test is steam. Since it was converted to 197ppm for 4h, it was classified as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	There is no report of an isomer mixture. There is data of rat LC50: 1.53mg/L (DFGOTvol.19 (2003)) about 2, 4-Xylidine. The concentration of the saturated vapor at 25degC is 180 ppm (0.89mg/L), and 1.53mg/L is considered to be mist. And if it is exposure for 4 hours, it is equivalent to category 2. However, there is no publication of exposure time, it cannot be classified by this data.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	There was no report of a mixture. It was classified as out of Category from the statement of having no stimulativeness in the rabbit test with 2,4 isomer (DFGOTvol.19 (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is no report with a mixture, and although there is a stimulative (DFGOTvol.19 (2003)) statement by the examination of the rabbit of 2,4 isomer, its recovery is unstated, so it cannot to set as Category 2A or 2B. It is more desirable to set to 2A from a viewpoint of safety if subdivision is required in a display etc.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	For in vivo tests, we found the findings that 2,6 isomer gave negative by mouse micronucleus assay (ACGIH (2002)), and for in vitro examination we found the statement that all the isomers gave the positive by the Ames test (they had metabolic activity), and with the eucaryotic cells, 2,4 isomer and 2,5 isomer induced DNA repair, 2,4 isomer (without the metabolic activity) and 2,6 isomer (with metabolic activity) induced the chromosomal abnormalities, 2,4 isomer gave positive in comet assay (DFGOTvol.19 (2003)), and 2,6 isomer showed positive in the chromosomal aberration test with the CHO cell (ACGIH (2002)). However, there was no report of the in vivo examination with the mixture of this product, therefore we could not classify it.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	Classified in "A3" (ACGIH)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (respiratory system), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	There is the description that pulmonary congestion occurs of the below 2.2mg/L of inhalation exposure (mist) in the guidance value of the category 2 in the test of rat about 2,4 isomer (DFGOTvol.19 (2003)). And there is the anesthetic action in the 1.06mg/L/4h of inhalation exposure in the guidance value of the Category 2 in the mouse test of isomer mixture (DFGOTvol.19 (2003)). And there is the irritation to nose in the above 0.5mg/L inhalation exposure in the rat test of 2,4 isomer (DFGOTvol.19 (2003)). So it is classified into Category 3 (anesthetic action). And about respiratory irritation, include disorder of lung above, it is classified into Category 2 (respiratory tract system).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood, liver, kidney, gallbladder, spleen)	Warning	H373	P260 P314 P501	It was classified as to Category 2 (blood) according to the statement which causes methemoglobinemia to humans (HSDB (2005))(priority 2). About methemoglobinemia, there is also a report of the inhalation atmospheric exposure test of a rat, a mouse, a dog and a rabbit (ACGIH (2002)), and the oral study of a rat 7(DFGOTvol.19 (2003)). Furthermore, although there is no isomer mixtures' test reports, there are some statements; by oral administration to a rat of 2.4, 2.6 isomers of 157mg/kg each for 20 days (90-day conversion : 35mg/kg), 2.4 isomer had a disorder in the liver, the kidney, and the gallbladder and 2.6 isomer had a disorder in the spleen(ACGIH (2002)); by oral administration of 2.6, 2.4, and 2.5 isomer by 50mg/kg/4W (90-day conversion : 17mg/kg) to a dog had a liver damage (ACGIH (2001)); in inhalation exposure of 0.1-0.3 mg/L for 28 days (90 day conversion: 0.03-0.1 mg/L) to the rat of 2.4 isomer, it had a disorder in the liver and the spleen(DFGOTvol.19 (2003)). Since these dose and exposure concentrations were within the guidance value of 2, it was categoried into Category 2(liver,kidney,gallbladder, spleen).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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