NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	131-17-9
Chemical Name	Diallyl phthalate
Substance ID	m-nite-131-17-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	A flash point is 166 deg C (Closed cup) (HSDB (Access on June 2013)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is an allyl group, which is an unsaturated bond in the molecule, but the classification is not possible due to no data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 358 deg C (ICSC (2006)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 from LD50 data of 656 mg/kg (females), 891 mg/kg (males), 896 mg/kg (SIDS (2005)), and 970 mg/kg (DFGOT vol. 9 (1998)) in tests with rats.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification) from LD50 of 3,300 mg/kg (SIDS (2005)) and 3,800-3,900 mg/kg (DFGOT vol. 9 (1998)) for rabbits.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on LC50 values for rats of 4.47 mg/L (SIDS (2005)) and 8.3 mg/L (1 hour, converted value: 2.1 mg/L/4 hours) (SIDS (2005)) (because these were higher than the saturated vapour pressure concentration of 0.002 mg/L (ICSC (2006)), a reference value in the unit of mg/L was applied as dust/mist). In the previous classification, Category 4 was thought to be mistaken for Category 3 from the rationale. The inhalation test by 4-hour exposure to dust/mist was added in this classification.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	The results of three tests are reported in SIDS (2005). In a skin irritation test with rabbits of reliability 1 (according to GLP and 16 CFR 1500.41), after a 24-hour occlusive application of 0.5 mL of this substance to the back, the primary skin irritation index was 0.5, and it was slightly irritating. And in a skin irritation test with rabbits of reliability 2 (according to DOT 49 CFR 173.1200), after a 4-hour occlusive application of 0.5 mL of this substance, the primary skin irritation index was 0, and it was not irritating. Furthermore, it is also described in PATTY (6th, 2012) that there was no irritation after a 4-hour occlusive application of this substance, although the test details are unknown. It was classified as "Not classified" based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In SIDS (2005), there is a report on the results of three tests, and the reliability was 2 for one and 4 for two. In an eye irritation/corrosion test with rabbits (according to GLP and FSHA 16 CFR 1500), no irritation was observed in any of all six animals (SIDS (2005)). Based on this test result, it is concluded in SIDS (2005) that this substance is considered non-irritant to the eyes. It is also described in PATTY (6th, 2012) that the substance is not irritating to rabbit eyes, although the test details are unknown because it is an unpublished report. It was classified as "Not classified" based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In a local lymph node test with mice (LLNA method: according to GLP and OECD guideline 429), SI values were 3.23 for a 5% solution of this substance and 10.74 for a 50% solution (SIDS (2005)). Based on the data of reliability 1, it is concluded in SIDS (2005) that this substance is considered to be a skin sensitizer. It was classified in Category 1 based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for a positive result in a chromosomal aberration test with mouse bone marrow, because reproducibility within the test and dose-response relationship are unclear, and a micronucleus test with mouse bone marrow was negative, the substance was judged to be not clastogenic in vivo (SIDS (2005), Patty (6th, 2012)). Besides, in in-vitro tests, it was reported to be weakly positive in a bacterial reverse mutation test and positive in a chromosomal aberration test, a micronucleus test, and a mouse lymphoma test (SIDS (2005), Patty (6th, 2012), DFGOT vol. 9 (1998)). A weakly positive result in a reverse mutation test indicates the reactivity of this substance to DNA, and it is thought that further knowledge is needed to classify germ cell mutagenicity of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	In an oral dose carcinogenicity test with mice, an increased incidence of lymphoma was observed in males, but it was not considered to be clear effects caused by the administration of test substance. Probably the maximum tolerance dose had not been achieved in the mouse test, but it is concluded that no carcinogenicity was observed (NTP TR242 (1983)). In an oral dose carcinogenicity test with rats, an increased incidence of mononuclear cell leukemia was found in females of the 100 mg/kg dose group. However, it is described that because of the variability in the incidence of this tumor in aged animals and the difficulty in definitively diagnosing it, there was equivocal evidence of carcinogenicity in female rats. And there was no evidence of carcinogenicity in male rats (NTP TR284 (1985)). As described in the above, because of insufficient information on carcinogenicity, it was classified as "Classification not possible."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a reproductive/developmental toxicity screening test with rats, dystocia was observed in 3/10 females in the high dose group (SIDS (2005)), but it was dystocia which was all observed before death, and it was thought to be secondary effects caused by marked maternal toxicity, not toxicity on fertility. On the other hand, in a developmental toxicity test with rats, only developmental toxicity (lower values of body weights, delayed ossification) was seen in fetuses at the doses where maternal animals showed severe general toxicity such as death (2/10 animals) and reduced weight gain (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009)). From the above, although toxicity on fertility was not found in females, there is no fertility information in males, and lower values of body weights and delayed ossification in fetuses are insufficient to assign reproductive toxicity. Therefore, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 2 (liver)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an inhalation test with rats, lesions were observed in the respiratory organs, but they were necropsy findings in dead animals (SIDS (2005)). In oral administration, elevated activities of serum enzymes (AST, ALT, alkaline phosphatase (dogs), ALT (rats)) indicating liver disorder were found at 800 mg/kg for dogs (SIDS (2005), DFGOT vol. 9 (1998)) and at 400 mg/kg for rats (DFGOT vol. 9 (1998)), and it is reported in NTP TR 284 (1985) that histopathological changes in the liver (periportal hepatocellular necrosis, doses unknown) were observed in rats. From the above, this substance was judged to cause liver disorder in experimental animals by single exposure at the doses within the guidance value range for Category 2, therefore it was classified in Category 2 (liver).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	Histopathological changes occurred in the liver in males at or below 50 mg/kg in an NTP's 13-week oral administration test with rats, but no changes were found in mice even after dosing at 400 mg/kg (SIDS (2005)). However, also in a reproductive/developmental toxicity screening test with rats, histopathological changes in the liver were observed in both males and females in the high dose group (SIDS (2005)), and it is thought that there is a difference between species. It was classified in Category 2 (liver) based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 96-hour LC50 = 0.23 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2005), it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 92, 79, 76% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991)), and 72-hour NOEC = 2.38 mg/L for algae (Pseudokirchneriella subcapitata) (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, there are data: 96-hour LC50 = 0.23 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2005). However, it is rapidly degradable (a degradation rate by BOD: 92, 79, 76% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1991)), and low bioaccumulation is estimated (log Kow = 3.23 (ICSC, 2004)). Therefore, it is classified as "Not classified." From the above results, it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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