Latest GHS Classification Results by the Japanese Government (edited by NITE)

Japanese



GENERAL INFORMATION
 
Item Information
CAS RN 133220-30-1
Chemical Name (RS)-2-[2-(3-Chlorophenyl)-2,3-epoxypropyl]-2-ethylindane-1,3-dione [indanofan]
Substance ID m-nite-133220-30-1_v1
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ（GHS classification results by the Japanese Government） To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link)  
Sample SDS by MHLW (External link)  
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Not classified (Not applicable)
-
-
- - There are no chemical groups associated with explosive properties present in the molecule. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Flammable gases Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Aerosols Not classified (Not applicable)
-
-
- - Not an aerosol product. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Oxidizing gases Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Gases under pressure Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Flammable liquids Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Flammable solids Classification not possible
-
-
- - Due to no data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group present in the molecule associated with self-reactive properties (epoxides), but the classification is not possible due to no data. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Pyrophoric solids Classification not possible
-
-
- - Due to no data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Self-heating substances and mixtures Classification not possible
-
-
- - No established test method suitable for solid substances with a melting point of 140 degrees C or lower. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- - Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13 Oxidizing liquids Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14 Oxidizing solids Not classified (Not applicable)
-
-
- - An organic compound that does not contain fluorine but contains oxygen and chlorine which are not chemically bonded to elements other than carbon or hydrogen. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15 Organic peroxides Not classified (Not applicable)
-
-
- - An organic compound that does not contain -O-O- structure in the molecule. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16 Corrosive to metals Classification not possible
-
-
- - No established test method suitable for solid substances. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501 		From reported LD50 values of 460 mg/kg (females) and 631 mg/kg (males) for rats (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)), it was classified in Category 4. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Dermal) Not classified
-
-
- - From a reported LD50 value of > 2,000 mg/kg for rats (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)), it was classified as "Not classified." FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Gases) Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Vapours) Not classified (Not applicable)
-
-
- - "Solids" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - The classification is not possible due to lack of data.
Besides, the category cannot be determined only from a reported LC50 value (4 hours) of > 1.57 mg/L for rats (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)).
A reference value of dust was applied because a test substance is a solid. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Skin corrosion/irritation Not classified
-
-
- - As a result of the application of 500 mg of this substance in an irritation test using rabbits, no skin irritation change at any observation point was reported. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010))
From the above, it was classified as "Not classified." 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264 		As a result of the application of 40 mg of this substance in an eye irritation test using rabbits, slight eye irritation was reported based on observed corneal opacity, conjunctival redness, edema, and discharges which reversed after 72 hours. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010))
From the above, it was classified in Category 2B. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Respiratory sensitization Classification not possible
-
-
- - Due to lack of data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501 		In a maximization test using guinea pigs, sensitization by this substance (a maximum positive rate 75%) was reported (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)).
On the other hand, a negative in a Buehler test was reported (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)).
Because the maximization test above is compliance with GLP corresponding to OECD TG406, and a high positive rate was reported, it was classified in Category 1. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Germ cell mutagenicity Classification not possible
-
-
- - From a negative in a micronucleus test by oral administration in mice (Pesticide abstract (2010)) in in vivo, and negatives in a bacterial reverse mutation test and a chromosomal aberration test in cultured mammalian cells (Japanese Journal of Pesticide Science Vol. 26 No. 3 (2001); Pesticide abstract (2010)) in in vitro, it was classified as "Classification not possible" in accordance with Guidance. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Carcinogenicity Classification not possible
-
-
- - In a carcinogenicity test by diet administration of this substance for 2 years in rats or 1.5 years in mice, in which rats were dosed up to 200 ppm where females showed reduced weight gain and low food consumption, and males and females showed non-neoplastic lesions, and mice were dosed up to 200 ppm for male and to 600 ppm for female where increases in in-between deaths occurred, but increased incidences of tumors related to administration of test substance were not observed. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010))
Therefore, it corresponds to "Not classified" in an oral route, but there is neither carcinogenicity information nor a carcinogenicity classification result by the international organization in other routes.
Therefore, it was classified as "Classification not possible" in this hazard class. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Reproductive toxicity Category 2


Warning
H361 P308+P313
P201
P202
P280
P405
P501 		In a two-generation reproductive toxicity test in rats by diet administration of this substance, in parent animals, eye abnormality in one each of F1 male and female at 100 ppm which was considered to be an effect by bleeding, an increased incidence of females without corpus luteum (5/27), and a slight decrease in ovary weight were observed. But the finding in ovary was judged as an incidental change. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)).
In offspring, in both F1 and F2 generations, internal hemorrhage by bleeding was confirmed by signs and necropsy during an early nursing period at 100 ppm, and eye abnormality by bleeding was also found. And in the same group in the F2 generation, an increased number of mothers with all dead pups, a decreased survival, low body weight, and a delay in time to achieve a reflex response in live offspring were observed. But decreased reflex response in the F2 pups was considered to be effects of a slight developmental delay. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010))
Besides, in an additional test with regard to bleeding signs and eye abnormality found in F1 and F2 pups in a 100 ppm group in the reproductive test, prolongation of blood coagulation time (PT/APTT) was observed in 1 and 2 weeks after birth as a result of a measurement of blood coagulation system in F1 pups after pregnant rats were administered 100 ppm in the diet through a gestation period and had a natural birth.
(Pesticide abstract (2010))
On the other hand, in a teratogenicity test in which pregnant rats or pregnant rabbits were orally administered this substance by gavage during an organogenetic period (rats: day 6 to 15 of gestation, rabbits: day 7 to 19 of gestation), in fetuses, an increased number of metacarpal bones in rats and an increased incidence of lumbar ribs in rabbits were observed as a result of administration up to 20 mg/kg/day where vaginal bleeding in a part of maternal animals occurred.
But it was reported that this substance does not have teratogenicity due to no toxicological significance or no findings relevant to skeletal malformation but skeletal variation. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010))
Because findings by bleeding during a nursing period in F1 and F2 pups and a decreased survival in F2 pups were observed at the dose where eye abnormality by bleeding was found as general toxicity effects in parent animals from the above, it was classified in Category 2 in this hazard class. 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation)



Danger
Warning
H370
H335 		P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312 		There are no human data.
Irritation was reported in experimental animals,
And increased spontaneous motility, decreased spontaneous motility, piloerection, salivation, hunched posture, tonic convulsion, clonic convulsion, tremor, tachypnea, bradypnea, and lethargy in oral administration in rats and mice (doses corresponding to Category 1), and lacrimation, salivation, decreased spontaneous motility, and irregular respiration in inhalation exposure to rats (a dose corresponding to Category 1) were reported. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010)).
This substance has effects on the central nervous system besides respiratory tract irritation from the above, therefore, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation). 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Specific target organ toxicity - Repeated exposure Category 1 (blood coagulation system), Category 2 (liver)


Danger
Warning
H372
H373 		P260
P264
P270
P314
P501 		In a 104-week diet administration toxicity test using rats, effects on blood coagulation system at 60 to 200 ppm (2.1 to 8.7 mg/kg/day) within a range of Category 1, and prolongation of PT and APTT, tar-like contents in an intestinal tract, massive bleeding as findings in a 200 ppm group were observed.
In a 13-week diet administration toxicity test using rats, effects on blood coagulation system (prolongation of PT and APTT, bleeding in the anterior chamber and so on) at 200 ppm (11.9 to 12.7 mg/kg/day) within a range of Category 2 were also observed.
In test using mice, effects on the liver (high liver weight and hepatocellular hypertrophy) besides effects on blood coagulation system (prolongation of PT and APTT) at 600 ppm (males: 68.1 mg/kg/day, females: 76.7 mg/kg/day) within a range of Category 2 in a 13-week diet administration toxicity test and effects on the liver (hepatocellular hypertrophy/necrosis) besides effects on blood coagulation system (prolongation of PT and APTT, bleeding tendency throughout the body and so on) at 100 to 600 ppm (14.4 to 58.7 mg/kg/day) within a range of Category 2 in an 18-month diet administration toxicity test were observed.
In tests using dogs, effects on the liver at 750 to1,500 ppm (22.1 to 47.1 mg/kg/day) within a range of Category 2 and high alkaline phosphatase activity, high liver weight, and hepatocellular hypertrophy as findings in a 1,500 ppm group in a 13-week diet administration toxicity test and at 500 to 1,500 ppm (12.3 to 38.7 mg/kg/day) within a range of Category 2 in a 1-year diet administration toxicity test were observed. (Pesticide abstract (2010); Pesticide evaluation report, Food Safety Commission of Japan (2010); Japanese Journal of Pesticide Science, Vol. 26 No. 3 (2001))
From the above, the effect on the blood coagulation system was mainly observed from Category 1. In addition, the effect on the liver was observed in a range of Category 2.
Therefore, it was classified in Category 1 (blood coagulation system), and Category 2 (liver). 		FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Aspiration hazard Classification not possible
-
-
- - Due to lack of data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word 		Hazard statement
(code) 		Precautionary statement
(code) 		Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Classification not possible
-
-
- - No data. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Hazardous to the aquatic environment Long term (Chronic) Classification not possible
-
-
- - No data. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Hazardous to the ozone layer Classification not possible
-
-
- - No data. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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