NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13410-01-0
Chemical Name	Sodium selenate
Substance ID	m-nite-13410-01-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water due to the water solubility result of 58.5 g/100 g measured (R.Lide (2010)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	The substance is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, although an LD50 value for rats of 1.6 mg/kg was reported (Environmental Risk Assessment for Chemical Substances Vol.14 (Ministry of the Environment, 2016)), the data is from RTECS listed in List 3, and details are unknown. Therefore, it was not adopted as the evidence of the classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a micronucleus test and chromosomal aberration tests using mouse bone marrow cells were positive. 　As for in vitro, bacterial reverse mutation tests, chromosomal aberration tests and a sister chromatid exchange test using cultured mammalian cells were positive (ATSDR (2003), Environmental Risk Assessment for Chemical Substances Vol.14 (Ministry of the Environment, 2016)). 　From the above, this substance was classified in Category 2 in accordance with the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	IARC classified selenium and selenium compounds in Group 3 (IARC Suppl. 7 (1984)). In addition, EPA classified selenium and selenium compounds excluding selenium sulfide (B2 (probable human carcinogen)) in Group D (IRIS Summary (1991)) since evidence of carcinogenicity in humans and experimental animals is insufficient. From the above, this substance was classified as "Classification not possible" for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In humans, it is reported that while ingestion of diet containing high level of selenium affects the sperm quality such as decreased sperm motility, there are reports that there are no effects (ATSDR (2003)). An increasing trend of spontaneous abortions (relative risk [RR] = 1.73; 95% CI = 0.62 - 4.80) was suggested for women in Italy who had ingested drinking water containing selenate, but it was not a statistically significant increase. In addition, body weight and length of live born of the selenium-exposed group were not different from those of live born of the unexposed group, and there was no increase in the incidence of congenital abnormalities (ATSDR (2003)). 　As for experimental animals, it is described that in a three-generation study using mice dosed by oral route (drinking water), about half of the F3 generation failed to breed at 0.57 mg Se/kg/day (ATSDR (2003)), and that in a short-term reproductive toxicity study using rats dosed by oral route (drinking water), adverse effects on sexual function/fertility in females (a decrease in the number of corpora lutea, a decrease in the number of implantations per litter, shorter estrous cycle) were observed at the dose (0.418 mg Se/kg/day) where maternal toxicity (significant reduction in water consumption, etc.) was manifested (ATSDR (2003)). In addition, it is described that in a two-generation study in which potassium selenate was orally administered to rats, at 0.35 mg Se/kg/day where suppression of the body weight gain was observed in maternal animals, about half of F2 pups died, and at 1.05 mg Se/kg/day, decreased fertility index and decreased survival rate of pups were observed (ATSDR (2003)). 　From the above, by oral administration of this substance or potassium selenate to experimental animals, effects on sexual function and fertility were observed in general at the general toxic doses of parent animals, and it was judged as appropriate that this substance was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, one case is reported in which after ingesting approximately 22 mg/kg of this substance by suicidal attempt, a 15-year-old girl showed diarrhea and abnormality in electroencephalogram and that an increase in blood bilirubin concentration and alkaline phosphatase activity was observed (ATSDR (2003), HSDB (Access on September 2016)). Since it was the only case, it was not adopted as the evidence of the classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (skin, hair, nail, teeth, central nervous system, liver, kidney, bone)	Danger	H372	P260 P264 P270 P314 P501	As for experimental animals, in a 2-year carcinogenicity study using rats dosed by feeding, softening of the bones was observed at 0.2 mg/Se/kg/day, which is equivalent to Category 1, and mottled surface of the liver and nephritis in the kidney were observed at 0.1 mg Se/kg/day. In a lifetime test using mice dosed by drinking water, amyloidosis of the major organs was observed (ATSDR (2003)). 　As for humans, although not this substance, there is a report of selenosis with hair loss or morohological changes of the nails in Enshi County, Hubei Province, China where selenium content in foods is high (Environmental Risk Assessment for Chemical Substances Vol. 14 (Ministry of the Environment, 2016), IRIS Summary (1991), ATSDR (2003)), furthermore, lowered hemoglobin, mottled teeth, skin lesions and effects on the central nervous system (peripheral anesthesia, acroparesthesia, and pain in the extremities) were reported (IRIS Summary (1991)). 　This substance is soluble in water, and it is thought that this substance would cause similar selenosis when orally ingested. 　Of the described above, amyloidosis observed in mice was a spontaneous lesion that is common in the mouse strain (Swiss) used in the experiment, and it was considered that the possibility of extrapolation to humans was small, therefore, it was not adopted as the evidence of the classification. 　Therefore, this substance was classified in Category 1 (skin, hair, nail, teeth, central nervous system, liver, kidney, bone).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 96-hour LC50 = 0.057 mg/L for crustacea (Gammarus pseudolimnaeus) (Environmental Risk Assessment for Chemical Substances vol. 14 (Ministry of the Environment, 2016)), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to unknown environmental dynamics of the inorganic compound, and 28-day NOEC (reproduction) = 0.05 mg/L for crustacea (Daphnia pulicaria) (Environmental Risk Assessment for Chemical Substances vol. 14 (Ministry of the Environment, 2016)), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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