NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13463-40-6
Chemical Name	Iron carbonyl
Substance ID	m-nite-13463-40-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	The flash point is -15degC (ICSC (2004)) and the boiling point is 103degC, which is classified into Category 2. Classified into Class 3 and Division 6.1 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Not classified based on the "Technical Guideline of GHS Classification of Physical Hazard" (Mar.10, 2006) since the substance is Classified into Class 3 and Division 6.1 (UN#1994) by the UN Recommendation on the Transport of Dangerous Goods, though it has the flash point of 50degC (ICSC (2004)) and may be pyrophoric when in contact with air, which could be classified into "Category 1."	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (insoluble, ICSC (2004))	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	Classified as a powerful reducing agent by ICSC (2004), though being inorganic compounds containing oxygen	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Not organic compounds	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	Classified into Class 3 and Division 6.1 (UN#1994) (UN Recommendation on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat LD50 (oral route) value of 25mg/kg representing the lower of the two testing data, 25mg/kg (RTECS (2006)) and 40mg/kg (IUCLID (2000)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Based on the LD50 value of 105mg/kg calculated from the testing data of rabbit LD50 (dermal route) of 56mg/kg (RTECS (2006)), 240mg/kg, 250mg/kg and 170mg/kg (males) (IUCLID (2000)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the rat LC50 (4 hours) value of 0.32mg/L (equivalent to 40ppm), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.91mg/L (30 min) (equivalent to 115ppm) (ATSDR (2001)), was lower than 90% of the saturated vapour concentration (46,000ppm) under a saturated vapour pressure of 35torr (25degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on the description in the report on rabbit skin irritation tests (4 hour application) performed in accordance with OECD Test Guideline (IUCLID (2000)): "Not irritating."	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Based on the description in the report on rabbit eye irritation tests performed in accordance with OECD Test Guideline 405 (IUCLID (2000)): "Not irritating."	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to the insufficiency of data (no data available on in vivo mutagenicity/genotoxicity tests)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, nervous system, cardiovascular system), Category 2 (liver, kidney)	Danger Warning	H370 H371	P308+P311 P260 P264 P270 P321 P405 P501	Based on the human evidence including "liver and kidney damage; central nervous system degeneration" (HSDB (2005)), "pathological lesions including hepatization of the lung, vascular disorder and central nervous system degeneration" (PATTY (4th, 1999)), and the evidence from animal studies: "clinical symptoms following exposure include respiratory depression, cyanosis, tremor and motor paralysis" (ACGIH (7th, 2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. Since the referenced studies for the effects on human liver and kidneys are assigned a priority rating of 2, these effects are classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, blood system, respiratory organs)	Warning	H373	P260 P314 P501	Based on the description in ICSC (J) (1995): "The substance adversely affects the liver, inducing hepatic dysfunction." Also based on the evidence from animal studies: "Treatment-related histopathological changes occurred in the lung; a slight but significant increase in carboxyhemoglobin was detected" (IUCLID (2000)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, the substance is classified into Category 2 since the priority rating of referenced studies is 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Since it was suggested that relevant toxicity is not indicated within the water solubility (100mg/L (IUCLID (2000)) of this substance in spite of 48 hours EC50=130mg/L and EC0=62.5mg/L of the crustacea (Daphnia magna) (IUCLID (2000)), it was classified into Not classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it was not water-insolubility (the water-solubility =100mg/L (IUCLID, 2000)), and acute toxicity was low, it was classified into Not classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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