NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13472-45-2
Chemical Name	Sodium tungstate
Substance ID	m-nite-13472-45-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 730 g/L (20 degrees C) (GESTIS (Access on September 2015))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound that contains oxygen, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	From a reported LD50 value of 1,190 mg/kg for rats (DFGOT vol.23 (2007), ATSDR (2005)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is reported that in a patch test in 853 workers, as a result of application of this substance (5 to 20%), 2% subjects showed irritant pustular reactions (DFGOT vol. 23 (2007)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported that in an eye irritation test using rabbits, as a result of application of 100 mg this substance, slight conjunctival irritation was observed (ATSDR (2005), PATTY (6th, 2012)). From the above, it was classified in Category 2B.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is reported that in a patch test in 853 workers, as a result of application of this substance (5 to 20%), sensitization was not observed (DFGOT vol. 23 (2007)), and that sensitization was found in 3 out of 20 animals in a maximization test using guinea pigs (DFGOT vol. 23 (2007)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As data on a dihydrate of this substance, not this substance, as for in vivo, both micronucleus tests using rat and mouse erythrocytes were negative (ATSDR Addendum (2015)), and a comet assay using mouse bone marrow cells was positive (ATSDR Addendum (2015)). As for in vitro, for a dihydrate of this substance, a bacterial reverse mutation test was negative, and for this substance, there are positive and negative data in chromosomal aberration tests using human lymphocytes, a sister chromatid exchange test was negative, and a chromosomal aberration test using cultured mammalian cells was negative (ATSDR (2005), ATSDR Addendum (2015)). From the above, this substance was classified as "Classification not possible" in accordance with the Guidance.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	No carcinogenicity information in humans. As for experimental animals, it is written that rats or mice were dosed with this substance in drinking water at a 5 ppm concentration as tungsten for 540 days, an increased incidence of tumors was not observed (DFGOT vol. 23 (2007)). On the other hand, it is written that in a test in which female rats were intravenously injected 50 mg N-methyl-N-nitrosourea (NMU) after 14-day administration of a tungsten compound (not specified) containing 150 ppm tungsten, an increased incidence of breast cancer and shortened time up to occurrence of breast cancer were shown 125 days after NMU injection in tungsten administered groups (DFGOT vol. 23 (2007), ATSDR (2005)). From the above test results, a conclusion cannot be drawn on the carcinogenicity of this substance, and there is no classification result by other organizations. Therefore, the substance was classified as "Classification not possible" for this hazard class due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	There is no information on human reproductive effects. As for experimental animals, in a test in which male rats were mated with untreated female rats after 55-day gavage administration of this substance at 50 mg/kg/day, effects on fertility, sex hormone, and sexual organ weights were not observed (ATSDR Addendum (2015)). However, it is written that in a test in which male rats were mated with untreated female rats after 3-month diet administration of this substance corresponding to 275 mg/kg/day, increased density and function of testis Leydig cells and increased levels of serum testosterone, LH, and FSH were found (ATSDR Addendum (2015)). On the other hand, it is written that also in a test in which female rats were mated with untreated male rats after 3-month diet administration of this substance corresponding to 275 mg/kg/day, an increased serum FSH level and a decreased serum progesterone level were observed (ATSDR Addendum (2015)). Besides, as a result of gavage administration of this substance in male and female rats for 70 days before mating and through mating and gestation until day 20 of nursing, an extension of a gestational period was found at 125 mg/kg/day of high dose. However, in a similar test using mice, effects on fertility and sexual function were not observed (ATSDR Addendum (2015)). Besides these, it is reported that in a test in which female rats were administered a tungsten compound (not specified) in the diet for maximum eight months including pre-pregnancy and pregnancy periods and had a Caesarean section on day 20 of gestation and fetuses were observed, fetal toxicity and delayed ossification were found. However, there is the remark that details are unknown due to the insufficient description (ATSDR (2005), DFGOT vol. 23 (2007)). As above, although variations of sex hormone levels occurred in both males and females in a test to assess reproductive effects in rats in the administration of this substance in an oral route, specific changes in sexual function and toxic effects on fertility were not shown. However, there is not enough test result using pregnant animals to assess developmental effects. Therefore, the substance was classified as "Classification not possible" for this hazard class due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	There are no human data on this substance. As for experimental animals, anorexia, incoordination, and dyspnea were described in oral administration in guinea pigs (ACGIH (7th, 2001), DFGOT vol. 23 (2007)). However, the classification cannot be given due to unknown details on doses and so on. From the above, the classification is not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	The classification is not possible because appropriate data are not obtained.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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