NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	135-19-3
Chemical Name	beta Naphthol
Substance ID	m-nite-135-19-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	No data available. Besides, there is the information that it is combustible (ICSC (2005)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 550 deg C (ICSC (2005)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on reports of LD50 values of 1,320 mg/kg (OECD TG401) (SIDS (2006)), 1,960 mg/kg, and 1,980 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)) for rats, this substance was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are reports of LD50 values for rats and rabbits that were both > 10,000 mg/kg (SIDS (2006)), but the details were not clear. Therefore, this substance was classified as "Classification not possible." Besides, in this reclassification, the category was changed due to revising the information source.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on a report of an LC50 value (4 hours) of 2.2 mg/L (OECD TG403) for rats (SIDS (2006)), this substance was classified in Category 4. Based on a description that the test was performed with the aerosol, the reference value for dusts and mists was used. Besides, there was another report of an LC50 value (1 hour) of > 0.77 mg/L (converted 4-hour equivalent value: 0.1925 mg/L) for rats (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is described that, in a skin irritation test with rabbits (OECD TG 404), after 500 mg of this substance was applied under semi-occlusive conditions for 4 hours, the Draize score was 0 (SIDS (2006)). From the above, this substance was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was reported that in an eye irritation test with rabbits, conjunctivitis, corneal opacity, and iritis were observed on the application of this substance (100 mg), and severe eye irritation was seen (SIDS (2006)). In addition, it was reported that an increased incidence of conjunctivitis was observed among workers exposed to this substance (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). From the above, this substance was classified in Category 2A.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	In a maximization test with 10 guinea pigs (OECD TG406 GLP-compliant), this substance was reported to be sensitizing (100% positive) (SIDS (2006)). Additionally, this substance was reported to be positive in a separate sensitization test with guinea pigs (SIDS (2006)). As for occupational exposures, it was reported that contact dermatitis was observed in 21 out of 303 workers who had handled this substance (SIDS (2006), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). From the above, this substance was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, this substance was negative in a micronucleus test with bone marrow cells of mice dosed by gavage (JECDB (Access on November 2015), SIDS (2006)). As for in vitro, this substance was negative in bacterial reverse mutation tests (SIDS (2006)). Besides, the category was changed by revising the GHS classification guidance for the Japanese government and the information sources.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Since there are no classification results by other organizations, classification was not possible due to lack of data. Besides, it is described that in a two-stage carcinogenicity study with female mice applied transdermally, promoter action by this substance was not detected (SIDS (2006)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a one-generation reproduction toxicity study, in which this substance was administered by gavage to male rats for 98 days including 10 weeks prior to mating and during the mating period, and to female rats from 2 weeks prior to mating, during mating and pregnancy, and until day 20 of lactation, in the parental animals, symptoms such as decreased motility, salivation, and nasal discharge were seen in both males and females at or above 40 mg/kg/day, however, at up to the high dose of 160 mg/kg/day, no abnormality in copulation, pregnancy, and delivery was seen, and no histopathological changes were found in the reproductive organs of males and females (JECDB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). However, it was described that at 160 mg/kg/day, while no clear signs of abnormal nursing behavior was seen in the dams, a trend toward a decrease in birth index, a reduced viability index at day 4 after birth, reduced litter sizes, and slightly suppressed growth by day 21 after birth were observed in the pups of this group, and it is reported that there were no effects caused by adverse effects on the dams but effects on genesis/postnatal development of the offspring were shown (JECDB (Access on November 2015), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). Regarding this data, it was noted in SIDS that depressed activity was observed in the dams at 160 mg/kg/day, suggesting the neonatal deaths were caused by the possibility of suppression of nursing capability, and 160 mg/kg/day was thereby judged to be a dose causing a reproductive effect (suppression of nursing capability) (SIDS (2006)). The judgment is dependent on the information source as to whether the cause of neonatal deaths at 160 mg/kg/day was due to nursing disorders in the maternal animals or not. Other than this, there was no further information available for classification of this substance for the reproductive effects, and there was no data from developmental toxicity tests with pregnant animals. Therefore, this substance was classified as "Classification not possible" due to lack of data for this hazard class. Besides, the category was changed due to the addition of the new information sources in this reclassification.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, blood system, kidney), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for humans, it was reported that this substance caused nausea, vomiting, abdominal pain, diarrhea, convulsions, hemolytic anemia, and kidney damage by oral ingestion, cough, sore throat by inhalational exposure, and kidney damage, corneal and lens opacities, and hyperemia of the ocular fundus by transdermal exposure (Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009), HSDB (Access on November 2015)). In experimental animals, reduced activity, exhaustion, irregular respiration, diarrhea, and eyelid closure were observed in the oral dose (1320 mg/kg bw, equivalent to Category 2) in rats, and irregular respiration, reduced activity, and impaired motility and reflexes were observed in inhalational exposure (2.2 mg/L, equivalent to Category 2) of rats (SIDS (2006)). From the above, this substance causes the effects on the central nervous system, haemal system, and kidney, in addition to respiratory tract irritation. Therefore, it was classified in Category 1 (central nervous system, haemal system, kidney) and in Category 3 (respiratory tract irritation). Besides, the category was changed by revising the GHS classification guidance for the Japanese government or information sources.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver, kidney, urinary bladder, blood system)	Danger	H372	P260 P264 P270 P314 P501	As for human, while the details were unknown, it is reported that impairment of kidney function with dysuria, nephrosis, and inflammation of the urinary bladder were observed in 303 workers (140 men and 163 women) who were exposed at 1-200 mg/m3, and increased incidences of gastritis, chronic hepatitis, impairment of the nervous system, and effects on the blood (increased reticulocyte count, decreased leukocyte count, etc.) were also seen (SIDS (2006), Environmental Risk Assessment for Chemical Substances Vol.7, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2009)). As for experimental animals, it is reported in a study where rats were exposed by inhalation for 1-4 months, impairment of the function of the liver and kidney and blood clotting were observed (SIDS (2006)). However, this description was insufficient to be used for the rationale of the classification. From the above, although the details were unknown, it is reported that effects mainly on the kidney but also on the urinary bladder, liver, nervous system, and haemal system were seen in humans. Therefore, it was classified in Category 1 (nervous system, liver, kidney, urinary bladder, haemal system). Besides, in this reclassification, the classification result was changed because effects on organs other than the kidney were described in the information source which was also used in the previous classification, and a similar description was found in a newly added information source.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour LC50 = 0.85 mg/L for crustacea (Gammarus minus) (SIDS, 2006), it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being rapidly degradable (a degradation rate by 2-week BOD = 68.4%, a degradation rate by TOC = 73.0%, a degradation rate by GC = 100% (Official Bulletin of Ministry of International Trade and Industry, 1976)), and 27-day NOEC = 0.001 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2006), it was classified in Category 1.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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