NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13517-17-4
Chemical Name	Disodium chromate decahydrate
Substance ID	m-nite-13517-17-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Since it is a nonflammable anhydride combined with crystal water (ICSC (J), 2001), it was considered to be nonflammable and classified asout of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Since it is nonflammable (ICSC (J), 2001) anhydride combined with water of crystallization and it is considered nonflammable, it was carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is what the nonflammable (ICSC (J) 2001) anhydride was combined with crystal water, and was considered nonflammable. Therefore, it was carried out the outside of category.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water (the water solubility is obtained)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	ICSC (J) (2001) and HSDB (2005) describe that the anhydride is a "strong oxidizer," this product is also considered to have a strong oxidativity. But we cannot classify it because of insufficient data.	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	The LD50 values for sodium chromate anhydride (CAS: 7775-11-3) are 87mg/kg in male and 40mg/kg in female (both EU-RAR (2005)). Because the molecular weight of the decahydrate (approx. 342) is about twice as much as that of the anhydride (approx. 162), the LD50 values were converted to approx. 175mg/kg for male and approx. 80mg/kg for female, and the substance was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	-	- Warning	-	-	It is rabbit LD50 = 1330mg/kg (EU-RAR (2005)) to a sodium chromate anhydrides (CAS:7775-11-3). In 10 hydrate, a molecular weights (about 342) was about twice the anhydride (about 162). And it was set as Category 5 based on concersion rabbit LD50 = about 2800mg/kg.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	It is a liquid in the definition of GHS. In addition, although this product is an existing deliquescent yellow crystals, the melting points is belw 19.9degC (it can be dissolved in water of crystallization).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Rat LC50 = 0.104mg/L/4h to the sodium chromate anhydrides (CAS:7775-11-3) carried out in the state of mist (EU-RAR (2005)). Since a molecular weights of 10 hydrate (about 342) was as about twice as the anhydride (about 162). So it was converted to LC50 = about 0.2mg/L/4h, and it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In anhydrides of this product (in Sodium chromate (CAS:7775-11-3), there is description that the deep ulcers which shows corrosive and severe irritation to human skin is started (ICSC(2005);SITTIG (4th, 2002)). Furthermore, in the European risk phrases, it was classified with caustic (C;R34) (EU-Annex I (Access on June 2006)), it was set as Category 1A-1C. In addition, further categorizing from this data is difficult.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Due to the descriptions that anhydrides of this product (Sodium chromate (CAS:7775-11-3)) shows causticity to the human eye, and it produces serious depths burn and the visual impairment (ICSC(2005);SITTIG (4th, 2002)), it was classified into Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	About the anhydride of this substance (Sodium chromate (CAS: 7775-11-3)), in addition to repetition or long-term inhalation exposure to human may cause asthma (ICSC(2005)), it is classified into "R42 (inhalation may cause sensitization)" according to the EU risk phrases. Moreover, chromium and chromium compound were classified into "the 2nd group (material considered that there is probably sensitizing to human)" in Japan Association of Industrial Health, and chromium was classified into the material with respiratory sensitization in Japanese Society of Occupational Allergy Special Committee, this product thought that it had respiratory sensitization and was set to Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	About the anhydride of this substance (Sodium chromate (CAS: 7775-11-3)), in addition to there is a description of showing sensitivity to a human skin (ICSC(2005), and SITTIG(4th, 2002)), it is classified into "R42 (inhalation may cause sensitization)" according to the EU risk phrases. Moreover, since hexavalent chromium compound was classified into "Sh (risk of skin sensitization)"in DFG, chromium and chromium compound were classified into "the 1st group (material which has sensitizing clearly to human)" in Japan industrials society, this product was considered to have skin sensitization, and was set to Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Although it is only a positive in an in vitro mutagenicity test (Ames, chromosome aberration) as data of the this product (a sodium chromate anhydrides (CAS:7775-11-3) is included) (IARC 49, 1990), about the flood solubility hexavalent chromium compound, there is the mutagenicity knowledge in in vivo was indicated (NTP RoC (11th, 2005), IARC49 (1990), EU-RAR (2005)). So and it is classified into Category 2. Refer to potassium dichromate (ID 262, Chemical Abstracts Service:7778-50-9).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	As hexavalent chromium compounds, since it was was classified K (Chromium hexavalent (VI) compounds) in NTP (2005), group 1 (Chromium(VI)) in IARC (1990), and A (as Chromium(VI), Inhalation route) in EPA (1986), respectively, it was classified into Category 1A.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Since there is no detailed data and also the data is insufficient for this product, it cannot classify. In addition, refer to potassium dichromate (ID 262, CAS: 7778-50-9) about the reproductive toxicity of hexavalent chromium compounds.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, kidney, liver)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In the inhalation test (guess at mist) to the rat written in the document of Priority 1, the necrosis of pulmonary edemas, inflammation, and a bronchial epithelium are observed at 0.028mg/L /24h of sodium chromate anhydrides (CAS:7775-11-3) (EU-RAR (2005)). This dose is equivalent to 0.17 mg/L /4h, and when converting into the amount of 10 hydrate (about 0.34 mg/L /4h), it is included in the guidance value of Category 1. Moreover, since there are descriptions that a soluble hexavalent chromium compound affects liver, the kidney, and respiratory organs in ACGIH-TLV (2005). Furthermore, in the inside of the document in Priority 2, "caustic is in a human airway, the caustic by oral ingestion are showed, kidney and liver are affected, and a tissue is injured" (ICSC (2005)), it was considered as Category 1 (the respiratory system, kidney, liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, kidney, liver)	Danger	H372	P260 P264 P270 P314 P501	Because of the document of Priority 1 that effects on liver, kidney and respiratory tracts occured by water soluble hexavalent chromium compounds (ACGIH-TLV (2005)), and of the description "human respiratory tracts are affected, nasal septal perforations are occured, and kidneys are damaged" in the document of Priority 2 (ICSC (2005), SITTIG (4th, 2002)), it was classified into Category 1 (respiratory system, kidney, liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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