NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13674-84-5
Chemical Name	Tris(1-chloro-2-propyl) phosphate
Substance ID	m-nite-13674-84-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	It was classified as "Not classified" based on a flash point of 185 deg C (closed cup) (SIDS (2009)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 500 deg C (IUCLID (2000)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information: water solubility of 1.6g /L (IUCLID (2000)), it is recognized that it does not react vigorously with water.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine but contains oxygen and chlorine, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are reports on LD50 values of > 500 mg/kg (males), 632 mg/kg (females), 707 mg/kg (females), 1,011 mg/kg (females), < 2,000 mg/kg (males), 2,800 mg/kg (females), and 3,300 mg/kg (females) for rats (all EU-RAR (2008)). It was classified in Category 4 to which the most data correspond.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on LD50 values of > 12.9 g/kg (EU-RAR (2008)), and > 2,000 mg/kg (NICNAS (2001), SIDS (2009)) for rats, and LD50 values of > 2,000 mg/kg (EU-RAR (2008), NICNAS (2001)) and > 5,000 mg/kg (EU-RAR (2008)) for rabbits.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" based on reports on LC50 values (4 hours) of 4.6 mg/L (SIDS (2009)), > 5.05 mg/L (males), about 5 mg/L (females), and > 7 mg/L (EU-RAR (2008)) for rats. Besides, based on the description of aerosol, a reference value of dust and mists in the unit of mg/L was applied.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	In SIDS (2009), there are four reports on test results on this substance including products. Among them, in a representative Draize test with rabbits, a primary irritation score was 0.5 out of 8, and there was no difference between normal skin and damaged skin. Furthermore, primary irritation scores after 24 and 72 hours were 0.5 out of 8 and 0.0 out of 8, respectively, and there was almost no irritation. Therefore, it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In SIDS (2009), there are reports on five test results on this substance including products. Among them, in a representative Draize test with rabbits, average scores after 1, 24, 48, 72 hours were 3, 0, 0, 0 out of 110, respectively, and eye irritation was not observed. Therefore, it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in micronucleus tests with peripheral blood of mice and rats and a chromosomal aberration test with rat bone marrow cells (EU-RAR (2008), NTP DB (Access on August 2013)). And it was negative in a comet assay with rat liver (EU-RAR (2008)). As for in vitro, it was positive or negative in mouse lymphoma tests with cultured mammalian cells, and negative in a bacterial reverse mutation test (ATSDR (2012), EU-RAR (2008), NTP DB (Access on August 2013)). Among these, the positive result in the mouse lymphoma test was "small colony" and was thought to result from chromosomal aberrations. However, it was negative for chromosomal aberrations in vivo as mentioned above, therefore it was judged not to cause chromosomal aberrations. Besides, it is described in NICNAS (2001) that it was not genotoxic in vivo and in vitro.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Teratogenicity was not observed in a developmental toxicity test and a two-generation reproductive toxicity test with rats in the oral route (feeding). In the two-generation reproductive toxicity test with rats in the oral route (feeding), effects on estrus cycles and uterus weight and developmental failure of offspring were found (EU-RAR (2008), SIDS (2009)). Therefore, it was judged to be Category 2.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	After oral administration, rats showed symptoms thought to be via the central nervous system such as increased or decreased activity, ptosis, hunched posture, tremors, clonic/tonic convulsions, sporadic twisting, aggression, teeth chattering, salivation, red-brown staining around the mouth, diarrhea, piloerection, rough coat, alopecia, dehydration, hypothermia, emaciation, dyspnea within the guidance value range for Category 2 (464-2,000 mg/kg). Therefore, it was classified in Category 2 (central nervous system). Furthermore, because decreased activity, partially or completely closed eyes, body weight depression, alopecia, convulsions, dyspnea were observed after inhalation exposure (mist) in rats outside the guidance value range (5.05 mg/L) (SIDS (2009), EU-RAR (2008)), it was classified in Category 3 (narcotic effects).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, thyroid)	Warning	H373	P260 P314 P501	It is described that in a 13-week diet administration test with rats, increased liver weight and thyroid follicular cell hyperplasia were observed in males at the dose (corresponding to 52 mg/kg/day) within the guidance values for Category 2 (EU-RAR (2008), IUCLID (2000)). In a 28-day gavage administration test with rats, effects on the liver (weight increase, hepatocyte hypertrophy, decreased serum ALT) were found only at the highest dose (1,000 mg/kg/day) (EU-RAR (2008), IUCLID (2000)). On the other hand, the effects on the thyroid were findings only in males, but they were judged to be of pathological importance. From the above, it was classified in Category 2 (liver, thyroid).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	From 96-hour LC50 = 51 ppm for fish (Pimephales promelas) (EU-RAR, 2008), it was classified in Category 3.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a 28-day degradation rate by BOD = 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1989)), and 72-hour NOEC (r) = 6 mg/L for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a 28-day degradation rate by BOD = 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and 96-hour LC50 = 51 ppm for fish (Pimephales promelas) (EU-RAR, 2008). From the above results, it was classified in Category 3.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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