NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	137-05-3
Chemical Name	Methyl 2-cyanoacrylate
Substance ID	m-nite-137-05-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Based on a flash point of 82.78 deg C (closed cup) (ACGIH (7th, 2001)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is an unsaturated bond (olefins) in chemical structure, but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 485 deg C (Dictionary of Organic Compounds (Kodansha Scientific, Ltd., 2004))	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Not classified	- -	-	-	Steel and aluminum may be used as a container (HSDB (Access on August 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	There are reports that LD50 values for rats were 1,600-3,200 mg/kg (ACGIH (7th, 2001)), and that there was no death from 5,000 mg/kg administration to rats (CICAD 36 (2001)). The category cannot be identified in one case, but another case corresponds to "Not classified." Therefore, it was classified as "Not classified." The LD50 value of the evidence for the previous classification was corrected to 1,600-3,200 mg/kg, and the category was revised.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of > 11,000 mg/kg for guinea pigs (ACGIH (7th, 2001)), this substance was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a report of an LC50 value (6 hours) of 101 ppm (converted 4-hour equivalent value: 123 ppm) for rats (ACGIH (7th, 2001)), this substance was classified in Category 2. Besides, since the LC50 value was lower than the saturated vapor pressure concentration (< 2,700 ppm), a reference value in ppm units was applied as vapor without mist.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Information suggesting Category 2 was obtained in (1)-(3), but information indicating "Not classified" was obtained in (4)-(6). Because conflicting results are reported, it was classified as "Classification not possible." [Evidence Data] (1) It was classified in Skin Irrit. 2 in EU CLP. (2) It is reported that in a skin irritation test with rabbits (Guideline 83/467/EC No. 8 (corresponding to OECD TG 404), n = 3), after 4-hour semi-occlusive application of undiluted this substance, irritation of erythema score: 3 and edema score: 1.5 was seen, and two out of three animals did not recover after 14 days (REACH registration dossier (Accessed Dec. 2018)). (3) It is described in CICAD that no conclusions can be drawn regarding whether allergic contact dermatitis from exposure to this substance and ethyl 2-cyanoacrylate was induced by an allergenic or irritation mechanism (CICAD (2001)). (4) It is reported that there is evidence that based on human data on this substance, single exposure is not irritating to the skin, but repeated exposure is irritating (CICAD (2001)). (5) It is reported that in a skin irritation test with rabbits (Code of Federal Regulations 191.11 (corresponding to OECD TG404), n = 3/group), after 24-hour occlusive application of undiluted this substance (purity 88.8%), skin irritation of erythema score: 0.33 was found after 72 hours (REACH registration dossier (Accessed Dec. 2018)). (6) It is reported that in a skin irritation test with rabbits, after 24-hour semi-occlusive application of undiluted this substance (purity about 100%), skin irritation of erythema score: 0.75 was observed after 72 hours, but there were no signs of edema (CICAD (2001)). [Reference Data, etc.] (7) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders, or mucous membrane irritation) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (8) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as the skin-damaging substance for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 594 in the Industrial Safety and Health Regulations.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There is a report that in an eye irritation test with rabbits, as the result of application of this substance, mean scores for irritation were conjunctival redness, 1.37; conjunctival edema, 0.96; corneal opacity, 1.00; and iritis, 0.48, and a recovery tendency was shown in the symptoms in the 72-hour observation period (CICAD 36 (2001)). In addition, there is a report that also in humans, reversible eye irritation was seen (ACGIH (7th, 2001)). From the above results, this substance was classified in Category 2B. Besides, this substance was classified as "Eye. Irrit. 2 H319" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	[Rationale for the Classification] Sufficient information on this substance alone to enable classification in respiratory sensitization was not obtained. However, because this substance is commonly used in a mixture with ethyl 2-cyanoacrylate, this substance was classified in Category 1 based on data (1) (2) and the assessment by ACGIH. [Evidence Data] (1) Many cases are reported in which adhesives containing this substance and ethyl 2-cyanoacrylate induced occupational asthma (ACGIH (2017), CICAD (2001)). (2) ACGIH judged this substance and ethyl 2-cyanoacrylate as respiratory sensitizers based on case reports from the past to the present (Lozewicz et al., 1985; Nakazawa, 1990; Quirce et al., 2001; Lindstrom et al., 2013), and it classified a group of this substance and ethyl 2-cyanoacrylate as RSEN and recommended warning industrial hygienists of the possibility that exposure to these substances at lower concentrations affects part of workers (ACGIH (2017)). [Reference Data, etc.] (3) It is described in CICAD that no conclusions can be drawn regarding whether asthma from exposure to this substance and ethyl 2-cyanoacrylate was induced by an allergenic or irritation mechanism (CICAD (2001)). (4) It is described in DFGOT: there is limited number of case reports in which adhesives containing this substance; ethyl 2-cyanoacrylate cause respiratory sensitization, if they exist, effects of combined exposure to cyanoacrylates have to be taken into account even if respiratory sensitization exists; the mechanism of action of cyanoacrylates is not clear; therefore, no conclusions can be drawn that they are sensitizing (DFGOT Vol. 13 (1999)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Sufficient information on this substance alone to enable classification in skin sensitization was not obtained. However, because this substance is commonly used in a mixture with ethyl 2-cyanoacrylate, this substance was classified in Category 1 based on data (1) (2) and the assessment by ACGIH. [Evidence Data] (1) Many cases are reported in which adhesives containing this substance and ethyl 2-cyanoacrylate induced allergic contact dermatitis (ACGIH (2017), CICAD (2001)). (2) Contact dermatitis and other symptoms were observed in 12 workers who set precious stones using this substance. Level measurement in a simulated work environment gave an air concentration of 0.4 ppm, and the possibility of irritative symptoms was ruled out because a ventilation system was installed (ACGIH (2017)). (3) ACGIH judged this substance and ethyl 2-cyanoacrylate as skin sensitizers based on case reports from the past to the present (Bruze et al., 1995; Conde-Salazar and Guimaraens, 1998; Constandt et al., 2005; Bhargava et al., 2012), and it classified a group of this substance and ethyl 2-cyanoacrylate as DSEN and recommended warning industrial hygienists of the possibility that exposure to these substances at lower concentrations affects part of workers (ACGIH (2017)). [Reference Data, etc.] (4) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as Simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (skin disorders, respiratory tract disorders, or mucous membrane irritation) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare. (5) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as the skin-damaging substance for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 594 in the Industrial Safety and Health Regulations. (6) It is reported that in skin a sensitization test with guinea pigs, this substance was not sensitizing (ACGIH (2017), CICAD (2001), REACH registration dossier (Accessed Dec. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a micronucleus test with bone marrow cells of mice was negative (CICAD 36 (2001)). As for in vitro, bacterial reverse mutation tests were positive, and mammalian cell gene mutation tests were negative (DFGOT Vol. 1 (1990), CICAD 36 (2001), ACGIH (7th, 2001), NTP DB (Access on October 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There are no classification results by other organizations, therefore, it was not possible to classify due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance is an irritant to the respiratory tract (ACGIH (7th, 2001), CICAD 36 (2001), DFGOT Vol. 1 (1990)). There was no other data in humans and experimental animals. From the above, this substance was classified in Category 3 (respiratory tract irritation).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the kinematic viscosity is calculated to be 2.0 mm2/sec (25/20 deg C) from the numerical data (viscosity: 2.2 mPa*s (25 deg C), density (specific gravity): 1.1012 g/cm3 (20 deg C)) listed on HSDB (Access, August 2015).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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