Item | Information |
---|---|
CAS RN | 13814-96-5 |
Chemical Name | Lead bis(tetrafluoroborate) |
Substance ID | m-nite-13814-96-5_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Pb), but it is estimated that it does not react vigorously with water due to the information that it is soluble in water and stable only in an aqueous solution (R.Lide (2010)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an inorganic compound containing halogen (F) (but not oxygen), but the classification is not possible due to no data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, there is the information of being corrosive to aluminum (HSDB (Access on September 2016)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
There is no information on this substance. Information on lead acetate, lead chloride, lead nitrate, and lead bromide was used for the classification. As for in vivo, positive results were observed in chromosomal aberration tests using mouse or rat bone marrow cells, micronucleus tests using rat bone marrow cells and sister chromatid exchange tests using mouse bone marrow cells. However, several of negative results also exist (IARC 87 (2006)). As for in vitro, positive results were observed in bacterial reverse mutation tests, gene mutation tests, and micronucleus tests using mammalian cultured cells. In addition to those test systems, several of negative results in chromosomal aberration tests also exist (IARC 87 (2006)). From the above, according to the GHS Classification Guideline for the Japanese Government, this substance was classified in Category 2. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
There is no data for this substance itself both in humans and experimental animals. However, IARC classified inorganic lead compounds in Group 2A as there is limited evidence in humans and sufficient evidence in experimental animals for the carcinogenicity of inorganic lead compounds (IARC 87 (2006)). In addition, ACGIH classified elemental lead as A3 and its inorganic compounds (ACGIH (7th, 2001)), the Japan Society For Occupational Health (JSOH) classified lead and compounds as Group 2B (Recommendation of Occupational Exposure Limits (2016)). From the above, it was decided that these classifications for inorganic lead compounds by other organizations should be adopted for this hazard class. According to the GHS classification guidance for the Japanese government in which evaluation by IARC is to be given preference, this substance was classified in Category 1B. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Category 1A |
Danger |
H360 | P308+P313 P201 P202 P280 P405 P501 |
It is reported that a decrease in spermatologic parameters in male workers exposed to inorganic lead compounds in battery plants (blood lead levels is 40 microg/dL or lower) was observed, and lead is toxic to sperm and can alter the endocrine function in adults (NTP DB (Access on September 2016)). Moreover, lead crosses the placenta and is accumulated in fetal organs, including the brain. High level exposure to inorganic lead can induce intrauterine death and stillbirth (NTP DB (Access on September 2016)). Even at lower levels, prenatal exposure to lead causes decreased growth and delays in early infant development (NTP DB (Access on September 2016)). As the classifications by other organizations, EU classified this substance as Repr. 1A and designated it as SVHC (ECHA Annex XV dossier (Access on October 2016)). Moreover, the Japan Society For Occupational Health (JSOH) classified lead and compounds as Group 1 Reproductive toxicant (Recommendation of Occupational Exposure Limits (2016)). From the above, this substance was classified in Category 1A. Moreover, boric acid which is a boron compound (CAS RN 10043-35-3) is also found to have reproductive and developmental toxicity in experimental animals and is classified in Category 1B (FY2013 GHS classification). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, kidney) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
There is no data on single exposure to this substance in humans or experimental animals. This substance is an inorganic lead compound, and there is information that this substance is soluble in water (IARC 87 (2006)). By ingesting the form of an aqueous solution, an inorganic lead compound forms ionized lead, and is considered to exhibit toxicity. In humans, apathy, restlessness, irritability, poor attention, headaches, muscular tremors, hallucinations, loss of memory, and nephropathy were reported as symptoms of acute toxicity of lead (OEL Documentations (Japan Society For Occupational Health (JSOH), 2013), ATSDR (2007), EHC 3 (1977)). From the above, this substance was classified in Category 1 (central nervous system, kidneys). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, blood system, cardiovascular system, kidney) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is no data for this substance, but it is described that repeated exposure to high concentrations of lead results in irreversible changes in the kidneys, including renal tubular atrophy, interstitial fibrosis, glomerulus sclerosis, and ultimately chronic nephritis (IARC 87 (2006)). It is reported that in an epidemiological study on patients with lead poisoning, hemoglobin level and hematocrit value significantly decreased compared to unexposed matched controls (ATSDR (2007)). Lead inhibits delta-aminolevulinic acid dehydratase and heme synthesis enzyme, and induces microcytic anemia and hypochromic anemia through inhibition of heme synthesis and shortening of the erythrocyte lifespan (ATSDR (2007)). On the other hand, there is a study supporting a relationship between chronic lead poisoning and myocardial damage. It is reported that workers with lead poisoning have electrocardiographic changes (ACGIH (7th, 2001)). From epidemiological studies, it was concluded that lead absorption causes significant increase in both the systolic and diastolic blood pressure (ACGIH (7th, 2001)). In addition, a reduction in motor nerve conduction velocity was found in workers with elevated blood lead concentrations (ACGIH (7th, 2001)). Parkinsonian symptoms were observed in 7 of 9 persons exposed to lead batteries for not less than 30 years (NICNAS (2007)). From the above, this substance was classified in Category 1 (nervous system, haemal system, cardiovascular system, kidney). Additionally, it is described that this substance may cause fluorosis, and the symptoms including weight loss, malaise, anemia, leukopenia, discoloration of the teeth and osteosclerosis (HSDB (Access on September 2016)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 96-hour LC50 = 18 mg/L for fish (Pimephales promelas) (AQUIRE, 2016; Curtis and Ward, 1981), it was classified in Category 3. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. Although environmental dynamics of the inorganic compound is unknown, and it is classified in Category 3 for acute toxicity, it was classified in Category 3. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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