NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	13952-84-6
Chemical Name	sec-Butylamine
Substance ID	m-nite-13952-84-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Since its flash point reported -9 degC (closed-cup) (ICSC (1999)) is < 23 degC and initial boiling point reported 63 degC (Merck (14th, 2006)) is > 35 degC, the substance corresponds to Category 2.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	Since its autoignition temperature is 378 degC (ICSC (1999)), it is considered that the substance does not ignite at room temperature.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Not classified	- -	-	-	Based on the information that steel and aluminum are durable as a container (Hommel (1996)), the substance was classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	The two LD50 values for rats of 152 mg/kg bw and 380 mg/kg bw for the substance were reported (PATTY, 5th (2001)), one of which corresponds to Category 3 and the other corresponds to Category 4. Selecting the category of greater hazard, Category 3 was adopted.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the rabbit LD50 value of 2500 mg/kg bw (JMPR 320 (1975)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	The rat LC50 value of 3.5 mg/kg bw was reported (JMPR 320 (1975)). However, since the exposure time was uncertain, the classification was not possible. Since LC50 value (3.5 mg/L) was lower than the saturated vapor pressure concentration (701 mg/L), it was judged the exposure was carried out with vapor.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In the rabbit test, the substance was reported as a primary irritant (JMPR 320 (1975)), and the substance was classified as "C; R35" (EC-JRC (ESIS) (Access on Jul. 2010)). Based on these documents, the substance was classified as Category 1. As relevant notes, contact with human skin causes irritation or burns or dermatitis (HSDB (2008)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified into Category 1 because its preexisting classification for skin corrosion/irritation is Category 1.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance could not be classified due to lack of in vivo test data. As relevant information, as for in vitro study, negative results in the Ames test were reported (JMPR 539 (1981), NTP DB (Access on August. 2010)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data were available. As relevant information, in the 2-year feeding study of sec-butylamine acetate in rats, there is no description of the findings for tumor incidence (HSDB (2008)).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Not classified	- -	-	-	Although there were no data of the substance concerned, the data regarding its acetate existed. In the four generation reproductive study by oral administration in rats, reproduction indices such as fertility index, gestation index, viability index and lactation index were normal (JMPR 320 (1975)). In the two-generation reproductive study by oral administration in rabbits, no effect on fertility, duration of gestation, delivery of live progeny or lactation indices were observed. There were no effects noted on survival of offspring in either generation (JMPR 320 (1975)). In the developmental toxicity study by oral administration in pregnant rabbits during the organogenetic period, the viability, which was evaluated using live fetus taken out at the end stage of gestation period by the incubation for 24 hours, decreased in comparison with the control group. However, there were no differences from controls with respect to reproduction, sex ratio or in the number of malformations observed (JMPR 320 (1975)). Because embryonic viability of rabbits was an item which was not performed in the usual developmental toxicity study, and the detail of the data was unknown, and the effect on survival of offspring was not observed in the two-generation reproduction study, therefore these descriptions were not adopted as the grounds for classification. As mentioned above, because there were no adverse effects on sexual functions and fertility of parental animals, and development of offspring, the substance was classified as the "Not classified" category.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	As the signs of toxicity in the acute oral toxicity study in rats (LD50 value: 380 mg/kg), following salivation, occurrence of convulsions and respiration paralysis were reported (JMPR 320 (1975)). In another acute oral toxicity study in rats (LD50 value: 152 mg/kg), sedation, loss of muscle coordination, rhinorrhea, gasping, and cramps were reported as poisoning symptoms (GESTIS (Access on August 2010)). Furthermore, there was a description that all amines examined showed stimulant action on central nervous system (PATTY, 5th (2001)). As stated above, although some data belonged to Category 1 judging from the guidance values, the information was obtained from the "List 2" information source designated in the GHS classification guidance for the Japanese government. Therefore, the substance was classified as Category 2 (central nervous system).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Although no data were available for the substance concerned, the data regarding its acetate existed. In the 3-month or 2-year feeding studies in rats, any treatment-related effects were not observed except for leukopenia and changes of some organ weights at the highest dose of 5000 ppm (converted dose into the substance concerned basis: 137 mg/kg/day) (JMPR 320 (1975)). Additionally, in the 2-year oral dose study in dogs, mydriasis was reported in all treated animals. Although lacrimation with keratitis occurred and all animals (4/4) died at the highest level of 250 mg/kg/day (converted dose into the substance concerned basis: 137 mg/kg/day), no treatment-related effects were noted at dose levels of 125 mg/kg/day (converted dose into the substance concerned basis: 69 mg/kg/day) or lower (JMPR 320 (1975)). The above results showed that no adverse effect occurred at the doses equivalent to those within the guidance values in both rats and dogs, and no toxic effects observed in rats treated even at the dose of 137 mg/kg/day which exceeded the range of the guidance values. Thus, the classification corresponded to "Not classified" for the oral route. While in the dermal route, no adverse reactions were reported in rabbits treated with 2 mL/kg/day (converted dose level as the substance concerned basis of 90-day study: 17.7 mg/kg/day) for 20 days. However, the information was inadequate to adopt for classification because the study was conducted with single dose level within the range of guidance values. No data were available for the inhalation route. Therefore, the classification for specific target organ toxicity (repeated exposure) was concluded as "Classification not possible".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 96h-LC50 = 46-68 mg/L for fish (Leusiscus idus) (HSDB, 2008).	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified as "Not classified" since it is rapidly degradable (28d-BOD degradation rate: 84, 94, 53% for NO2 and 109, 104, 68% for NH3 (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1980)) and its bioaccumulation potential is estimated to be low (Log Pow = 0.74 (PHYSPROP Database, 2011)) though its acute toxicity is Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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