NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	142-59-6
Chemical Name	Disodium ethylenedicarbamodithioate　[Nabam]
Substance ID	m-nite-142-59-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	There is a metal (Na) present in the molecule, but it is estimated that it does not react vigorously with water due to water solubility data of > 200 g/L (20 deg C, GESTIS (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on a reported LD50 value of 1,400 mg/kg for rats (Aquatreat DN-30 (containing approximately 30% nabam in aqueous solution)) (EPA RED (1996)), this substance was classified in Category 4 using a converted value of 420 mg/kg calculated as containing 100% of this substance. 　Besides, there is a report that the LD50 value for rats is 395 mg/kg (EHC 78 (1988), JMPR (1965)). This report, however, was not used for the classification because there is no description regarding the amount of the test substance contained.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Based on a reported LD50 value of >2,000 mg/kg for rabbits (Aquatreat DN-30 (containing approximately 30% nabam in aqueous solution)) (EPA RED (1996)), the converted value calculated as containing 100% of this substance is >600 mg/kg. However, a category cannot be identified from this value alone. Therefore, classification is not possible.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, an LC50 value of > 2.19 mg/L for rats is reported (EPA RED (1996)), but there are no details regarding the amount, etc. of the test substance and it was not possible to identify the category from this value alone. Therefore, classification is not possible.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	There is information that the pure form of this substance causes irritation to the skin (HSDB (Access on November 2016)). Also, it is reported that as a result of applying this substance (19%) to the arm of 25 humans, 2 showed mild erythema and itching (EHC 78 (1988)). However, these data were judged as insufficient for use in the classification since the details are unknown. 　Besides, in a skin irritation test using rabbits, no irritation was observed by application of a solution containing 30% of this substance. Therefore, EPA RED classified this substance as Category IV (EPA RED (1996)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, in an eye irritation test using rabbits, no irritation was observed by application of a solution containing 30% of this substance. Therefore, EPA RED classified this substance as Category IV (EPA RED (1996)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is described that, as a result of applying this substance (19%) to the arm of 25 humans, 2 persons showed mild erythema and itching and as a result of reapplication to the opposite arm after 14 days, 13 persons showed mild to strong erythema, edema and vesiculation, and from these findings, sensitization was suggested (EHC 78 (1988), EPA RED (1996)). From this information, EPA classified this substance as "Sensitizer" (EPA RED (1996)). 　Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, a chromosomal aberration test using rat bone marrow cells was negative (EPA RED (1996)). As for in vitro, a bacterial reverse mutation test was negative, in vitro mammalian cell gene mutation tests were negative and positive, and sister chromatid exchange studies were positive (EPA RED (1996)). In the above-mentioned in vitro mammalian cell gene mutation tests, the results were negative when mouse S9 was used, but positive with rat S9. This effect may be attributable to ethylene thiourea, a metabolite of this substance (EPA RED (1996)). 　Therefore, this substance was classified in Category 2 based on the characteristics of the metabolite and the positive results in the presence of a metabolic activation system in the in vitro tests although there is no positive finding in vivo.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, it is described in a study using mice administered by gavage at 21.5 mg/kg/day from 7 days of age to weaning and thereafter given by the diet at 73 ppm up to 18 months of age, no significant increase in tumors was found (EHC 78 (1988), HSDB (Access on November 2016)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	It is reported that in two developmental toxicity studies using rabbits orally dosed with a solution containing approximately 30% this substance (Aquatreat DN-30), increased incidences of fetal malformations such as hydrocephaly, domed cranium, and cleft palate, were observed at lower doses (8–10 mg/kg/day) than 100 mg/kg/day at which depressed body weight gain was seen in maternal animals (EPA RED (1996), HSDB (Access on November 2016)). Therefore, this substance was classified in Category 1B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)	Warning	H371 H335 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for humans, it is described that this substance is irritating to the skin and mucous membranes, and is a central nervous system depressant in high concentrations (HSDB (Access on November 2016)). Also, it is reported that multiple spraying workers exposed to high concentrations of this substance developed pharyngitis, rhinitis and bronchitis (HSDB (Access on November 2016)). 　As for experimental animals, although there is no description of animal species and administration route, it is reported that experimental animals acutely exposed to toxic doses of this substance exhibit first stimulation, then depression of central nervous system, bloody diarrhea, general weakness, and prostration, and that death was due to respiratory arrest (HSDB (Access on November 2016)). It is described that as the results of necropsy, severe irritation of the gastrointestinal tract and renal necrosis were seen in these animals, and that these effects may be due to carbon disulfide produced by decomposition of this substance in the acid environment of the stomach (HSDB (Access on November 2016)). 　Details were unknown regarding the effect on human skin. As for the effects on the gastrointestinal tract and kidney seen in experimental animals, there is no available information on the administration route and dose, even in the original source. Thus, these information were not adopted because it is difficult to determine a classification category. 　From the above, this substance was classified in Category 2 (central nervous system) and Category 3 (respiratory tract irritation, narcotic effects). Since HSDB is an information source in List 2, this substance was classified in Category 2 for the central nervous system.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (thyroid)	Warning	H373	P260 P314 P501	No information on humans is available. 　As for experimental animals, in a combined 90-day repeated dose toxicity study and neurotoxicity study using rats given a solution containing 31.1% this substance (Aquatreat DN-30) by gavage, a decrease in body weights and body-weight gains, a decrease in thyroxine, and an increase in absolute and relative thyroid weights were observed at 80 mg/kg/day (Nabam: 24.9 mg/kg/day) or more, which is equivalent to Category 2; and an increase in thyroid-stimulating hormone and mild hypertrophy of the follicular epithelium in the thyroid glands were observed at 260 mg/kg/day (Nabam: 80.86 mg/kg/day) (EPA RED (1996)). 　The findings in thyroid were considered to be due to direct effects on the thyroid since no effects on the liver were observed. 　Therefore, this substance was classified in Category 2 (thyroid).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour LC50 = 0.44 mg/L for crustacea (Daphnia magna) (EHC 78, 1988), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. Because rapid degradability data were not obtained, and it was classified in Category 1 in acute toxicity, it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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