NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	156-59-2
Chemical Name	cis-1,2-Dichloroethylene
Substance ID	m-nite-156-59-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 2.2-3.9 deg C (closed cup) and a boiling point of 60.1 deg C (HSDB (Access on December 2014)). Besides, it is classified in Class 3, PG II (UN1150) in UNRTDG.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, it is classified in Class 3, PG II (UN1150) in UNRTDG, not corresponding to self-reactive substances and mixtures, which is the higher precedence.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (GESTIS (Access on December 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on a report of an LC50 value (4 hours) of 13,700 ppm for rats (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)), it was classified in Category 4. Besides, the LC50 value was lower than 90% of the saturated vapor concentration (263,000 ppm), the reference value in units of ppm was applied as a vapour without a mist. Since new information sources (IRIS TR (2010), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) were added and the criteria for Category 4 was changed from 2,500-5,000 ppm in the previous classification to 2,500-20,000 ppm, the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since there are descriptions that an aqueous solution of this substance was irritating to human skin (Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)) and that this substance showed primary irritation to the skin and caused dermatitis (HSDB (Access on December 2014)), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is a description that an aqueous solution of this substance was irritating to human eyes (Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003)), and there is a description that 1,2-dichloroethylene, an isomer mixture containing this substance was irritating to the eyes (HSDB (Access on December 2014)). Besides, there is information that an isomer of this substance was corrosive to human eyes (ACGIH (7th, 2001)). From the above results, it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, it was negative or positive in mouse bone marrow chromosomal aberration tests, and it was negative in a sister chromatid exchange test with mice bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010), NTP DB (Access on Dec 2014)). As for in vitro, it was negative in a bacterial reverse mutation test, a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010), NTP DB (Access on Dec 2014)). A positive result in in vivo chromosomal aberration test was observed in only one test, which was conducted under a somewhat special condition in which a 1/6 amount of an LD50 value was administered 10 times. Therefore, IRIS TR (2010) described that although it was generally nonpositive, it was impossible to conclude the mutagenicity of this substance. From the above, it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified as "I" by EPA (IRIS TR (2010)), it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There was no information on this substance. In a dose-finding study of a teratogenicity test with mice given a mixture with the trans-isomer by the oral route, though limited test items, no abnormalities were observed in the examination of fetuses at doses where maternal toxicities were observed. Additionally, in a teratogenicity test with rats given the trans-isomer by the inhalation route, no significant fetal effects were observed at doses where maternal toxicities were observed (increased fetal resorption (within the range of historical data) was observed) (IRIS TR (2010)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	There is a description that this substance was narcotic to humans at high doses (ACGIH (7th, 2001)). As for experimental animals, it is described that inhalation exposure to rats caused narcotic effects but no death for 4 hours at 8,000 ppm (31.72 mg/L) and narcotic effects in 8 minutes and death in 4 hours at 16,000 ppm (63.44 mg/L) (PATTY (6th, 2012)). In addition, extension of sleeping time by hexobarbital and extension of anesthesia time by zoxazolamine were observed in an 8-hour inhalation exposure at 0.79 mg/L with rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Besides, nausea, vomiting, weakness, tremor, central nervous system depression, vertigo and narcotic effects were observed by inhalation exposure to humans to 1,2-dichloroethylene (the isomer mixed ratio was unknown) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Environmental Risk Assessment for Chemical Substances Vol. 2, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2003), OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)). As for trans-1,2-dichloroethylene, there were reports by oral administration to rats at 1,275 mg/kg, of decreased activity, ataxia, loss of righting reflex and depressed respiration, and of hyperemia in the pulmonary capillary and alveolar septal distention by a histopathological test (ACGIH (7th, 2001), ATSDR (1996)). Since there is also a description that there are differences in toxicities between the cis- and trans- isomers (details unknown) (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)), the toxicity data of a mixture and the trans-isomer was not used. From the above, since the main effects were narcotic effects based on the data of this substance, it was classified in Category 3 (narcotic effects).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There was no knowledge of hazard on exposure of humans to this substance. As for experimental animals, in a test in which rats were administered this substance by gavage for 90 days, although an increase in the relative liver weight was observed, no histopathological findings were observed at a dose (97 mg/kg/day) of the upper limit of Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010)). In addition, a decreased hematocrit value and reduced hemoglobin were observed. However, since both were the findings observed at a dose at the upper limit of Category 2 or at high doses exceeding Category 2 (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), IRIS TR (2010)), it was considered inadequate to use them for classification. Moreover, no inhalation exposure tests of this substance were conducted. From the above, although it was considered to correspond to "Not classified" by the oral route based on the oral administration test results with rats, since there was no toxicity information by other routes and hazardous knowledge in humans, it was classified as "Classification not possible" due to lack of data. In this regard, although this substance was classified in Category 2 (blood) in the previous classification, the blood was excluded from the target organs by considering the onset doses as described above. Besides, the trans-isomer (CAS RN: 156-60-5), an isomer of this substance, was also classified as "Classification not possible" due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 40.2 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 4.51 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)), although it is not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1990)), and 96-hour LC50 = 67.2 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2003), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). By drawing a comparison between the above results, it was classified in Category 3.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information