NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	156-62-7
Chemical Name	Calcium cyanamide
Substance ID	m-nite-156-62-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Classification not possible	- -	-	-	Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Because there is the information that a pure substance corresponds to "Not classified" due to being not combustible, but there is a fire risk in the presence of impurity (ICSC (J) (2006)), it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	It contains a metal (Ca) and reacts with water (ICSC (J) (2006)), but the classification is not possible due to no data. Besides, when it contains more than 0.1% calcium carbide, impurity, it is classified in Division 4.3, PGIII in UNRTDG (UN 1403) corresponding to Category 3. In addition, because in Special Provision 38 of UNRTDG, it does not correspond to Dangerous Goods when it contains not more than 0.1% calcium carbide, impurity, a pure substance corresponds to "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	It is an inorganic compound not containing oxygen or halogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are three reports of LD50 values for rats of 700 mg/kg (purity 40-60%, a converted value equivalent to 100% purity: 280-420 mg/kg) (Japan Crop Protection Association (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" (1992))), 765 mg/kg (purity 62-65%, a converted value equivalent to 100% purity: 474-497 mg/kg) (DFGOT Vol. 5 (1993)), and 690 mg/kg (purified products, EU SCHER (2016)), one of which corresponds to Category 3-4, and two to Category 4. By adopting the category with the larger number of cases, it was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	There is a report of an LD50 value for rabbits of >2000 mg/kg (purity 62%, a converted value equivalent to 100% purity: >1240 mg/kg) (DFGOT Vol. 24 (2007)), it corresponds to Category 4 or "Not classified," but since the category cannot be specified by this value alone, it was classified as "Classification not possible." The documents on the Agricultural Chemical Registration Application (2000) used in the previous classification was not used because it was not available and could not be confirmed. The classification result was changed from the previous classification due to the use of new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	There is a report of an LC50 value for rats of >0.155 mg/L in a 4-hour inhalation test (DFGOT Vol. 24 (2007)), but since the category cannot be specified by this value alone, it was classified as "Classification not possible." The classification result was changed from the previous classification due to the use of new information sources.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a report that in a skin irritation test of this substance with rabbits (in compliance with OECD TG 404), no skin irritation was observed with the dried substance, whereas the moistened substance showed mild to moderate irritation (DFGOT Vol. 24 (2007)). Also, there is a report that severe eye irritation is observed in humans (DFGOT Vol. 24 (2007)). Therefore, by judging comprehensively from these results, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	From reports that in eye irritation tests with rabbits (in compliance with OECD TG 405), necrosis of the nictitating membrane, corneal opacity and severe irritation were observed, or eye irritation such as conjunctival edema (grade 4) and erythema (grade 2), congestion of the iris (grade 2), and corneal opacity (grade 4) occurred on observation 7 days after an application (DFGOT Vol. 24 (2007)), it was classified in Category 1. Besides, there is a description that the aqueous solution of this substance is strongly alkaline (EU SCHER (2016)). In the EU CLP classification, this substance is classified in Eye Dam. 1 (ECHA CL Inventory (Access on June 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There is a report that this substance was positive in a modified maximization test (in compliance with OECD TG 406) with guinea pigs (EU SCHER (2016)). In addition, there is a report that a skin sensitization survey by patch test in 65 workers showed no sensitization (EU SCHER (2016)), but since it was not possible to deny the result of the animal test, it was classified in Category 1. The category was revised based on the information obtained in this survey.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, it was negative in a micronucleus test (EU SCHER (2016)). As for in vitro, it was weakly positive or negative in bacterial reverse mutation tests, negative in a mouse lymphoma test, a chromosome aberration test, and a sister chromatid exchange test with mammalian cultured cells (NTP DB (Access on June 2017), ACGIH (7th, 2001), EU SCHER (2016)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	In two-year carcinogenicity studies by dietary administration to rats and mice, no increased tumors associated with the administration was observed in rats (NTP TR163 (1979), ACGIH (7th, 2001), PATTY (6th, 2012)). As for mice, dose relationship was seen in hemangiosarcoma in males, however, it was not statistically significant. As for females, dose relationship was found in lymphoma or leukemia, there was a statistical significance in the high dose group, but the incidence was within background data (NTP TR163 (1979), ACGIH (7th, 2001), PATTY (6th, 2012)). Thus, neither the hemangiosarcoma in male mice nor lymphomas or leukemia in females was considered to be related to the administration of this substance, it was concluded that the test substance showed no carcinogenicity either in rats or in mice (NTP TR163 (1979), PATTY (6th, 2012)). As for classification results by other organizations, ACGIH classified it in A4 (ACGIH (7th, 2001)). From the above, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity study with pregnant rats dosed by gavage on gestational day 6-19, at 21 mg/kg/day or more where maternal toxicity (reduction in body weight gain and food consumption, a decrease in uterus weights) was observed, only a minor effect (lowered fetal body weight) was observed in the fetuses (EU SCHER (2016)). However, since there is no information on the effects on fertility and sexual function, classification was not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	There is a description that this substance causes irritation of the mucous membranes of the nose, throat and respiratory passages, which results in coughing, tickling in the throat, rhinitis and tonsillitis (DFGOT Vol. 5(1993)). As for experimental animals, there is a report in a single inhalation exposure test with rats, respiratory disorders, tremors, poor general state and loss of body weight occurred at 5.1 mg/L of a commercial product of this substance (a converted value equivalent to 100% purity: 3.16-3.32 mg/L which is calculated from a purity of 62-65% as described in DFGOT Vol. 5 (1993)) (DFGOT Vol. 24 (2007)). However, there was no description of the exposure time, and the original literature was also a non-disclosure document and cannot be confirmed, so it was not adopted. From the above, it was classified in Category 3 (respiratory tract irritation). Besides, the documents on the Agricultural Chemical Registration Application (2000) used in the previous classification were not adopted because they were not available, and the details are unknown. Therefore, the classification result was changed from the previous classification. Besides, it is believed that this substance is transformed into cyanamide (CAS RN 420-04-2) after oral administration, and that the toxic effects observed for this substance were mainly attributable to cyanamide toxicity (EU SCHER (2016)). Since cyanamide inhibits aldehyde dehydrogenase, it is used as a liquor amount inhibitor, and there is a statement that facial flushing, decreasing blood pressure, nausea, tachycardia, dizziness, dyspnea and decreased vision may occur after ingesting alcohol (and foods including alcohol etc.) with oral ingestion of cyanamide (Ethical Pharmaceuticals 2017 (2016)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (thyroid), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	As for humans, this substance has an alcohol suppression effect in the same way as cyanamide. For 65 employees who worked with nitrolime which is a product containing this substance as the main ingredient and various amounts of caustic lime, determination of their exposure concentration and examination by industrial physicians were conducted. As a result, the following is reported: the total period of employment was 5-41 years (average 19 years); exposure concentrations were 0.23-8.36 mg/m3; no exposure-related adverse effects were observed; and alcohol consumption 1-7 hours after work led to moderate alcohol intolerance reactions in 6 of the 22 employees and weak reactions in 7 (DFGOT Vol. 5 (1993)). As for experimental animals, there is data on the commercial product of this substance (containing 63% of this substance). In a 7-week repeated dose toxicity test by feeding with rats, at or above 0.04% (20 mg/kg/day, 13 mg/kg/day as this substance) (converted guidance value: 10 mg/kg/day) which is within a guidance value range for Category 1, reduced body weight gain was seen, at or above 0.06% (30 mg/kg/day, 19 mg/kg/day as this substance) (converted guidance value: 19 mg/kg/day), hyperplasia of the thyroid gland was found, and at or above 0.15% (60 mg/kg/day, 47 mg/kg/day as this substance) (converted guidance value: 26 mg/kg/day) which is within a guidance value range for Category 2, bile-duct hyperplasia was observed (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), NTP TR163 (1979)). Besides, in a 7-week repeated dose toxicity test with mice dosed by feeding, effects on the liver (slight hyperplasia of the bile duct, vacuolated periportal hepatocytes, focal necrosis of hepatocytes) were observed at doses above the guidance value range of Category 2 (Environmental Risk Assessment for Chemical Substances Vol.9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), NTP TR163 (1979)). From the above, in humans, effects related to alcohol metabolism disorder rather than a direct effect of this substance are observed, and in the experimental animals, the effects on the thyroid and liver are found within the guidance value ranges of Category 1 and Category 2, respectively. Therefore, it was classified in Category 1 (thyroid), Category 2 (liver). Besides, it is believed that this substance is transformed into cyanamide (CAS RN 420-04-2) after oral administration, and that the toxic effects observed for this substance were mainly attributable to cyanamide toxicity (EU SCHER (2016)). Cyanamide is classified in Category 1 (haemal system, thyroid, liver, genetic organs (men)) in the GHS classification by Japanese government, but this substance was classified only from the data of this substance. The classification result was different from the previous classification due to the use of a new information source.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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