Item | Information |
---|---|
CAS RN | 15875-13-5 |
Chemical Name | 1,3,5-Tris[3-(dimethylamino)propyl]hexahydro-1,3,5-triazine |
Substance ID | m-nite-15875-13-5_v1 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 100.5 deg C (closed cup) (REACH (Accessed May 2021)). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 215 deg C (744 mmHg) (REACH (Accessed May 2021)). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" (Category 5 in UN GHS classification). [Evidence Data] (1) LD50 for rats (males): 2,519 mg/kg (REACH registration dossier (Accessed May 2021)) (2) LD50 for rats (males): 4,650 mg/kg (REACH registration dossier (Accessed May 2021)) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 | P302+P352 P362+P364 P280 P312 P321 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 4. [Evidence Data] (1) LD50 for rabbits: 1,566 mg/kg (REACH registration dossier (Accessed May 2021)) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), no category could be identified and classification was not possible. Besides, the exposure concentration was lower than the saturated vapor pressure concentration (5,262 ppm: 73.6 mg/L) and the substance was judged as being in the vapor state. In addition, the exposure concentration was lower than 90% (66.3 mg/L) of the saturated vapor pressure concentration, and the judgment for this substance was made based on the reference value for gas (reference value in units of ppm). [Reference Data, etc.] (1) LC50 (8 hours) for rats: > 0.51 mg/L (converted 4-hour equivalent value: 0.72 mg/L: 51.4 ppm) (OECD TG 403) (REACH registration dossier (Accessed June 2021)) |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) It was reported that, in a skin irritation test with rabbits (n=6) (occlusive, 4-hour application, 21-day observation), mild erythema and edema were observed on the abraded skin but no skin irritation reaction was observed on the intact skin (REACH registration dossier (Accessed May 2021)). [Reference Data, etc.] (2) It was reported that, in a skin irritation test with rabbits (n=5) (open, 24-hour application, 24-hour observation), skin irritation whose score was 5 (full scale: 10) was observed at 24 hours after application but it was not a corrosive effect (REACH registration dossier (Accessed May 2021)). ⇒最高濃度(50%)で閾値(SI値:3)に等しい値が得られ、50%濃度群では皮膚の紅斑とともに、耳介重量の増加がみられたが、感作性影響かどうかは不明瞭であった (3) In a skin irritation test with rabbits (n=2) (occlusive, 8-day observation), this substance was applied for 1 minute, 5 minutes, and 15 minutes and no skin irritation reactions were observed at 24 to 72 hours after application. It was reported that, when it was applied for 20 hours, scaling was observed at 24 hours after application in one case and induration was observed at 72 hours after application in another case (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. [Evidence Data] (1) It was reported that, in an acute eye irritation/corrosion test with rabbits (n=2) (equivalent to OECD TG 405, 8-day observation), the eyes clotted at 72 hours after application in all cases and the effects were irreversible (REACH registration dossier (Accessed May 2021)). (2) It was reported that, in an eye irritation test with rabbits (n=8), irritation effects were reversible within 22 days in 5 cases in the washed eyes group, while irritation effects persisted until 30 days after application in 3 cases in the unwashed eyes group (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] In the findings of (1), negative results were obtained, and in the findings of (2), values equivalent to the threshold (SI value: 3) were obtained. Therefore, it was ambiguous whether this substance elicited a sensitizing response, and classification was not possible. [Reference Data, etc.] (1) It was reported that, in a local lymph node assay (LLNA) with mice (n=5/group) (OECD TG 429, GLP), the stimulation indices (SI values) were 1.01 (5%), 1.03 (10%), and 1.38 (25%) (REACH registration dossier (Accessed May 2021)). (2) In a local lymph node assay (LLNA) with mice (n=5/group) (OECD TG 429, GLP), the stimulation indices (SI values) were 1.22 (0.5%), 1.29 (5%), and 3.00 (50%). It was reported that, at the highest dose level (50%), values equivalent to the threshold (SI value: 3) were obtained, but an increase in ear weight together with erythema on the skin was observed in the 50% dose group, and it was ambiguous whether this substance elicited a sensitizing response (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There were no in vivo findings and classification was not possible due to lack of data. [Reference Data, etc.] (1) In a bacterial reverse mutation study, weakly positive results were obtained (REACH registration dossier (Accessed May 2020)). (2) In a gene mutation test using the mouse lymphoma cells, negative results were obtained (REACH registration dossier (Accessed May 2020)). (3) In a micronucleus study using the human lymphocytes, negative results were obtained (REACH registration dossier (Accessed May 2020)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Besides, since (1) was a screening test, it was not possible to judge that this substance had no reproductive toxicity. [Evidence Data] (1) It was reported that, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422, GLP, for a total of 28 days from 2 weeks prior to mating (males), for 41 to 54 days, i.e. during 2 weeks prior to mating, during mating, during post-coitum and during 5 days of lactation (females)), no reproductive toxicity was observed (REACH registration dossier (Accessed May 2021)). (2) It was reported that, in a developmental toxicity study (OECD TG 414, GLP, days 6-19 of gestation) with rats dosed by gavage, no developmental toxicity was observed (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 2 (nervous system). [Evidence Data] (1) It was reported that, in an acute oral toxicity test with mice, decreased activity, dyspnea, and diarrhea were observed at 1,500 mL/kg (1,380 mg/kg, within the range for Category 2); and tremors, convulsions, and death were observed at 2,000 mL/kg (1,840 mg/kg, within the range for Category 2) (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes. [Evidence Data] (1) It was reported that, in an oral toxicity test with rats dosed by gavage (OECD TG422, GLP, males: for 28 days, females: for 41 to 54 days), no effects were observed at 240 mg/kg/day (converted guidance value: 74.7 mg/kg/day (males) and 109 to 144 mg/kg/day (females), within the range for Category 2) and hematological effects (prolonged blood coagulation time (APTT), decreases in erythrocyte count/hemoglobin/hematocrit) and forestomach effects (inflammation, erosion, edema) were observed at 720 mg/kg/day (converted guidance value: 224 mg/kg/day (males) and 328 to 432 mg/kg/day (females), in the range corresponding to "Not classified") (REACH registration dossier (Accessed May 2021)). (2) It was reported that, in a 13-week oral toxicity study with rats dosed by gavage (OECD TG408, GLP), no effects were observed at 150 mg/kg/day (in the range corresponding to "Not classified") but forestomach effects (epithelial hyperplasia, ulceration, inflammatory cell infiltration or inflammation) and glandular stomach effects (ulceration) were observed at 500 mg/kg/day (in the range corresponding to "Not classified") (REACH registration dossier (Accessed May 2021)). |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 48-hour EC50 = 62.2 mg/L for crustacea (Daphnia magna) (REACH (Accessed May 2021)). | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 3 because it is not rapidly degradable (BIOWIN) and it was classified in Category 3 in acute toxicity. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2021 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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