Item | Information |
---|---|
CAS RN | 1663-39-4 |
Chemical Name | tert-Butyl acrylate |
Substance ID | m-nite-1663-39-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
Classified into Category 2 since flash point 10 degC (closed-cup) (IUCLID (2000)) is <23 degC and initial boiling point 121 degC (IUCLID (2000)) is >35 degC. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | Classified into Type G since the substance, which contains a stabilizer (hydroquinone monomethy ether 100 ppm) and is classified into Class 3, PG III in UNRTDG (UN2348), is distributed though there is unsaturated bond (acrylic acid) present in the molecule. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Classified into Not classified since auto-ignition point is 385 degC (Hommel (1996)) exceeding 70 degC. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance does not contain oxygen, fluorine or chlorine, or these atoms are chemically bonded only to carbon or hydrogen. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on LD50 values of 1047 mg/kg bw (SIAR Dossier (2005)) and 1056 mg/kg bw (IUCLID (2000)) for rats, the substance was classified into Category 4. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a LD50 value of >4000 mg/kg bw for rats (SIAR Dossier (2005)), the substance was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Vapours) | Category 3 |
Danger |
H331 | P304+P340 P403+P233 P261 P271 P311 P321 P405 P501 |
Based on a LC50 value of 7 mg/L/4h (1336 ppmV) for rats (SIAR Dossier (2005)), the substance was classified into Category 3. Since saturated vapour pressure concentration is 22,369 ppm (117 mg/L) based on vapour pressure of 22.66 hPa at 25.7 degC (SIAR Dossier (2005)), the test was considered to be conducted for vapour with almost no included mists and classification criteria for gas was adapted. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Since there is a report that moderate erythema and slight edema was caused at 24-hour but only scaling was observed 8 days after application in a rabbit skin irritation test (SIAR Dossier (2005)), and that the substance was "slightly irritating" (SIAR Dossier (2005)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, in EU classification, the substance is classified into Xi: R37/38. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Since there is a report that slight erythema and slight edema were observed 1-hour after application and only a marginal erythema was detected after 24-hour, but no effects were seen 8 days after the application (SIAR Dossier (2005)), the substance was concluded to be "slightly irritating" (SIDR Dossier (2005)). The substance was classified into Category 2B. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Based on a report that 4/10 animals were sensitized in a guinea pigs skin sensitization test (Maximization Test) (SIAR Dossier (2005)), the substance was classified into Category 1. As relevant information, the substance is classified into R43 in EU classification. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on a negative result in a mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity test) (SIAR Dossier (2005)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (SIAR Dossier (2005) and IUCLID (2000)). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
7 | Reproductive toxicity | Not classified |
- |
- | - | In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, significant systemic toxicity including mortality was observed in dams at a high dose level. Whereas the capability to cohabitate and to generate offspring were not affected at this dose level, the pre- and postnatal development of offspring was significantly impaired. The impaired postnatal development of the offspring was the consequence of an insufficient maternal care in the dams. So that means probably secondary to the marked maternal systemic toxicity (SIAR Dossier (2005)). Additionally, local effects, systemic toxicity, impairment of fertility and pre- and postnatal toxicity were not observed at the lower concentrations (SIAR Dossier (2005)). Based on this information, the substance was considered not to have adverse effects on sexual functions, fertility or development of offspring and was classified as "Not classified". | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, the concentration of 180 ppm (0.956 mg/L, 6 hr/day, 5 day/week) showed slight irritation to eyes and upper respiratory tract as well as impairment of body weight development in both sexes, mild impairment of renal function in the males, and reduced general state in both sexes. Two pregnant female animals in the group died. Both animals exhibited atrophy in the lymphoid tissues of spleen and thymus. Additionally, erosion/ulcer in the mucosa of the glandular stomach was observed in one animal (SIAR Dossier (2005)). Since repeated inhalation exposure of lower concentrations caused respiratory tract irritation, it is assumed that single exposure also causes respiratory tract irritation. The substance was classified into Category 3 (respiratory tract irritation). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (systemic) |
Warning |
H373 | P260 P314 P501 |
In a combined 15-week subchronic inhalation toxicity test with a reproduction/developmental toxicity screening test in rats, the concentration of 180 ppm (0.956 mg/L, 6 hr/day, 5 day/week) showed slight irritation to eyes and upper respiratory tract as well as impairment of body weight development in both sexes, mild impairment of renal function in the males, and reduced general state in both sexes. Two pregnant female animals in the group died. Both animals exhibited atrophy in the lymphoid tissues of spleen and thymus. Additionally, erosion/ulcer in the mucosa of the glandular stomach was observed in one animal (SIAR Dossier (2005)). Additionally, it was reported that the test compound evoked marked systemic toxicity including mortality in pregnant and lactating female rats at the high dose level (180 ppm) (SIAR Dossier (2005)). Based on the report, the substance was classified into Category 2 (systemic toxicity). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
Classified into Category 3 from its 24h-EC50 = 42 mg/L for Crustacea (Daphnia magna) (AQUIRE, 2010). | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Classified into Not classified since its bioconcentration potential is estimated to be low (LogKow = 2.09, KOWWIN) though the acute toxicity is Category 3. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|