NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1746-01-6
Chemical Name	2,3,7,8-tetrachlorodibenzo[b,e][1,4]dioxin
Substance ID	m-nite-1746-01-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 1	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	It was set as Category 1 based on rat LD50 values: 0.022mg/kg (PATTY 4th, 1994, IARC 69, 1997, NTP TR209, 1982, ATSDR, 1998), 0.013mg/kg (IARC 69, 1997), 0.043mg/kg (IARC 69, 1997, ATSDR, 1998), 0.34mg/kg (IARC 69, 1997), 0.100mg/kg (NTP TR209, 1982), 0.190mg/kg (NTP TR209, 1982), 0.125mg/kg (NTP TR209, 1982, ATSDR, 1998), 0.060mg/kg (ATSDR, 1998), and 0.164mg/kg (ATSDR, 1998).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	It was set as Category 1 based on rabbit LD50 value: 0.275mg/kg (PATTY 4th, 1994, IARC 69, 1997, ATSDR, 1998).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	From description that hyperkeratosis and epidermal hyperplasia were accepted in the acute dermatitis exposure tests using the mouse (ATSDR (1998)), and description that the skin was stimulated (ICSC (J) (2003)), it was set as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is the description that in the test applied to the ocular of the rabbit (ATSDR (1998)), inflammation such as conjunctival edemas was acknowledged. So it was set as Category 2A-2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Since there was a positive result in the chromosome aberration test on rat and mouse marrow cells which is an in vivo mutagenicity test with somatic cells (ATSDR, 1998), and there was no positive result in the in vivo heredity toxicity examination on germ cells. So it was classified as Category 2 .	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It was classified into group 1 (IARC 69, 1997), and classified into 1 in Japan Assoc. of Industrial Health (industrial hygene academic society recommentation, 2005) and classified into K in NTP (NTP RoC 11th, 2005). So it was considered as Category 1A.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	It was classified into Category 1B based on the description that reduced fertility potential was admitted in the rat fecundity study (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982)), description that embryonic lethality effects, fetal malformation, and reduction of newborn baby's immunity and fertility potential, etc. were observed also in single exposure, and in the pregnant rat, mouse or hamster oral administration examination (IARC 69 (1997), ATSDR (1998), NTP TR209 (1982),) and description that fetotoxicity was observed at dose lower than causing maternal toxicity in the monkey oral administration examination (IARC 69 (1997) and ATSDR (1998)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (skin, liver, immune system, endocrine system, bone marrow, reproductive organs, urinary organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	As effect by human disaster exposure of IARC 69 (1997), description that chlorance, liver-enzymes change, change of an immune systems or glucose metabolism is admitted, the description that chlorance and the effect of liver is admitted by acute exposure in humans of ATSDR (1998), and in the oral study using the guinea pigs, rats, mice and a monky of IARC 69 (1997), ATSDR (1998),NTP TR (1982), description that the effect on the immune systems thymic atrophy, etc, effect on liver such as enlargement of liver cells or vacuolation, etc., epithelium fault formation of a renal pelvis, a ureter, and a bladder, marrow, and the cell reduction in deferent, from description that the effect of the endocrine systems on changes of thyroid hormones etc. was admitted with the given dose of the guidance value range of Category 1. So it was set as Category 1 ( skin, liver, an immune systems, an endocrine systems, marrow, genitals, urinary organs)	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (skin, liver, immune system, endocrine system, nervous system, blood, kidney)	Danger	H372	P260 P264 P270 P314 P501	Based on descriptions that as effect of the human occupational exposure, chloracne, in liver-enzymes change, description that change of an immune systems or sugar metabolism is observed (IARC 69 (1997)), and humans evidence of exposure, hepatotoxicity, the effect of the endocrine systems on the skin influences of chloracne etc., sugar metabolism, thyroid dysfunction, etc., and the symptoms in peripheral and a central nervous systems are observed (ATSDR (1998)), and also that in the oral study using rat,mice or guinea pigs, the effect of the immunity systems on thymic atrophy etc., the denaturation of the effect of the blood on a liver damages, a thrombocytopenias, etc., the kidney, and the thyroid gland was obsserved with the given dose of the guidance value range of Category 1 ( IARC 69 (1997), ATSDR (1998),NTP TR209 (1982)), and it was classified into Category 1 (the skin, liver, an immune systems, an endocrine systems, a nervous systems, blood, kidney)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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