NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	1758-73-2
Chemical Name	Thiourea dioxide
Substance ID	m-nite-1758-73-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Category 1	Danger	H251	P235 P280 P407 P410 P413 P420	Classified into Category 1 since the substance is classified into Division 4.2, PG II, III in UNRTDG (rev. 15, 2007) (UN3341). However, it may be classified into Category 2 or Not classified by composition and form and it is desirable to confirm by conducting the designated test (IMDG Code).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance contains oxygen which is chemically bonded to atoms (S) except carbon and hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on LD50 values of 1565 mg/kg (male) and 1496 mg/kg (female) (OECD TG401 (GLP)) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)) and 1120 mg/kg (SIDS(access on Oct. 2009)) for rats, the substance was classified into Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >2000 mg/kg for rats (OECD TG402 (GLP)) (SIDS (access on Oct. 2009)), the substance was classified as "Not classified". It is unclear whether this substance was classified into Category 5 in GHS classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (room temperature)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a LC50 value (4h) of 0.164 mg/L for rats (OECD TG403 (GLP)) (SIDS (access on Oct. 2009)), the substance was classified into Category 2. Since there was a report of "aerosol" (SIDS (access on Oct. 2009)), the test was considered to be conducted for dust.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Although there are no data available on 4-hour application tests, the substance was moderately irritating to the intact skin and the Draize score was 3.3 in a rabbit 24-hour patch test (SIDS (access on Oct. 2009)) and the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	In a rabbit test, after 24-hour slight opacity of the cornea, slight iritis and moderate redness and slight to severe swelling of the conjunctivae were noted. Some of these effects recovered partially or completely in the course of the 7 day observation period. However, at 7 days slight to severe cornea opacity and vascularization of the cornea were observed in 4/6 rabbits, ulcus cornea in 2/6 rabbits, slight iritis in 3/6 rabbits and slight lesions of the conjunctivae in all rabbits. Based on a report of "severe" eye irritant (SIDS (access on Oct. 2009)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	Although no sensitizing result was reported in a guinea pig Draize test (SIDS (access on Oct. 2009)), classification was not possible since the test method is not approved by OECD.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	From in vivo tests, a mouse bone marrow micronucleus test (OECD TG474 (GLP)) resulted in a positive result but there is a report that "it was recommended by external experts to repeat the test". Three additional mouse bone marrow micronucleus tests (OECD TG474 (GLP) was followed in 2 tests) resulted in negative results (SIDS (access on Oct. 2009)). Therefore, the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of positive results in two Ames tests (OECD TG471) (SIDS (access on Oct. 2009, "Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)), and a CHL/IU cell chromosomal aberration test (OECD TG473 (GLP)) ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Additionally, a negative result was reported for an in vitro HGPRT test using CHO cells (OECD TG476 (GLP)) (SIDS (access on Oct. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422 (GLP)), decreases in estrus count, extension of the estrous cycle, numbers of corpora lutea and implantation, increased gestation days, all embryo absorption (3 dams), and decrease or decrease tendency in numbers of newborn, live newborn and the birth index were observed at doses at which parental effects such as decreased body weight gain were observed ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). The substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 2 (kidney), Category 3 (narcotic effects)	Danger Warning	H370 H371 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As effects on the respiratory system, in a rat 4-hour inhalation test (aerosol) (OECD TG403 (GLP)), clinical observations included difficulties in breathing, anemia and cyanosis as well as low locomotion at dose levels of 0.117 mg/L and higher. Necropsy revealed hemorrhages in the lungs at dose levels of 0.059 mg/L and higher, and histopathology revealed a corrosive action in the lung (multifocal fibrosis, inflammation, edema, congestion, loss of cilia etc.) at dose levels of 0.059 mg/L and higher. Trachea and nasal cavity were also affected (the details is not clear) (SIDS (access on Oct. 2009)). As effects on the kidney, in a rat oral test (OECD TG401 (GLP)), histopathology revealed grayish white in cortico-medullary junction area, basophilic renal tubule and interstitial fibrosis at dose levels of 1280 mg/kg and higher ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Additionally, as narcotic effects, in a rat oral test, sedation, ataxia and reduced reflexes were observed at a dose level of 1120 mg/kg (SIDS (access on Oct. 2009). Based on the above information, the substance was classified into Category 1 (respiratory system), Category 2 (kidney) and Category 3 (narcotic effects).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney)	Warning	H373	P260 P314 P501	No increase in frequency of substance related symptoms were observed in 85 workers exposed to the substance (SIDS (access on Oct. 2009)). In a combined repeat dose and reproductive/developmental toxicity test with rats (OECD TG422 (GLP)), at a dose level of 100 mg/kg (90-day equivalence: 54.4 mg/kg), effects on the liver including centrilobular hypertrophy of hepatocytes, basophilic material in the bile duct, vacuolization of hepatocytes, changes in blood chemical examination (increases of albumin, A/G ratio, triglycerides and phospholipids, decreases of glucose) and effects on the kidney including necrosis of the tubules, basophilic tubules, changes in blood chemical examination (increases of BUN, creatinine and inorganic phosphorus, decreases of potassium) were noted ("Toxicity Testing Reports of Environmental Chemicals" (Chemicals Investigation Promoting Council) (access on Oct. 2009)). Based on the above information, the substance was classified into Category 2 (liver, kidney). As relevant information, although edema, pneumonia, emphysema and atelectasis in the lung, hyperplasia and metaplasia in the spleen, and desquamation of the follicle epithelium in the thyroid were noted in a rat 9-month inhalation test (IUCLID (2000)), the results were not used as the basis of classification since exposure period per day was unclear.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 72h-EC50 = 32 mg/L for algae (Scenedesmus subspicatus) (SIDS, 2002).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since it is rapidly degradable (Readily biodegradable, BOD degradation rate: 71 - 93%) (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 1991) and its bioaccumulative potential is estimated to be low (LogKow = -3.37 (PHYSPROP Database, 2011) though the acute toxicity is Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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