NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	19750-95-9
Chemical Name	N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine monohydrochloride
Substance ID	m-nite-19750-95-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods suitable for solid materials are not established. In addition, ICSC (J) (1994) have the description "it corrodes many metals under presence of water."	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat LD50 = 268mg/kg calculated by the rat oral LD50 data : 305, 325 and 330mg/kg (EHC199 (1998)), 265 and 355mg/kg (JMPR206 (1972)) and 225mg/kg (RTECS (2003)), the substance was classified as Category 3. * Also refer to the information on N'-(2-Methyl-4-chlorophenyl)-N,N-dimethylfolmamizine (ID1357, CAS: 6164-98-3), which is the base compound of this substance.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	-	- Warning	-	-	It was set as Category 5 from rat dermal LD50 = 4g/kg (RTECS (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There is only data with rat inhalation LC50 (1hr) value >5.8mg/L (JMPR206 (1972)) (4-hour equivalent, in the case of steam >2.9mg/L, and in the case of mist/particulate >1.45mg/L). Since the data is insufficient, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	There is only a data with rat inhalation LC50 (1hr) value: >5.8mg/L (JMPR206 (1972)) (4-hour equivalent, in the case of steam: >2.9mg/L, and in case of mist and particulate: >1.45mg/L), and it cannot be classified since data is insufficient.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	It was set as Category 3 from description that the rabbit skin is stimulated slightly (EHC199 (1998)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Since there was description that "Mild" irritation was indicated as a result of the Standard Draize Test using a rabbit eye (RTECS (2003)), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Although there is description "dermatitis may be caused if the skin is contacted over repetition or a long period of time" to humans (ICSC(J)(1994)), it could not check with the thing resulting from an allergic reactions, but it was presupposed that data is insufficient and it cannot classify. In addition, it is supposed with the base compound (ID 1356, Chemical Abstracts Service:6164-98-3) of the this substance that it cannot classify.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	The reciprocal translocation test and a dominant fatality test using a mouse, the chromosome aberration test using a mouse spermatocyte, a mouse spot test, a Chinese hamster bone marrow micronucleus and chromosome aberration test shows the negative result (EHC199 (1998)). So it is classified as the out of the Category. In addition, it is reported that an Ames test and the mouse lymphoma test are negativity (EHC199 (1998)).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	There was a report that malignant hemangioendothelioma arose in subcutaneous tissue, the back peritoneum, and internal organs (the kidney, liver, spleen) in mice by feed-mix administration (EHC199 (1998), JMPR431 (1978)), it was set as category 2. In addition, the base compound (ID 1356, Chemical Abstracts Service:6164-98-3) of this substance is carried out the outside of category since it is classified into "Group 3" in IARC.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data. In addition, in the base compound of this substance (ID 1356, CAS: 6164-98-3), it is defined as "out of category".	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system, blood, urinary bladder, kidney)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	Since there was description (ICSC (J) (1994)), in the document of Priority 2, "this substance affects a nervous system and blood, produces a dysfunction, and may generate methemoglobin to humans. This substance may affect a bladder and the kidney and may produce the inflammation of a bladder, and hematuria", it was considered as Category 2 (nervous systems, blood, bladders, kidney). In addition, also refer to the information on the base compound of this substance (ID 1356, CAS: 6164-98-3).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (skin)	Warning	H373	P260 P314 P501	It was classified into Category 2 (skin) based on description of "dermatitis may be occured in repeated or long-term dermal exposure." (ICSC (J), (1994)). In addition, although the formation of methemoglobin was acknowledged as a result of the feeding administration during 24 months to rats of this product (JMPR467 (1979)), the toxic effect data is not found. Also refer to the information on the base compound (ID 1356, CAS:6164-98-3) of this product.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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