NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	21087-64-9
Chemical Name	4-Amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one, (Metribuzin)
Substance ID	m-nite-21087-64-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point is <=140 degC) substances are not available (melting point: 125.5 - 126.5 degC (Pesticide safety information (Japan Crop Protection Association) (Vol. 12, No. 1 (1987)), The Society of Synthetic Organic Chemistry, Japan, Dictionary of Organic Compounds, Kodansha (1985))).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are seven LD50 values for rats: (2020 mg/kg (male), 2220 mg/kg (female) (Pesticide safety information (Japan Crop Protection Association) (Journal of Pesticide Science vol. 12, No. 1 (1987)), 1100 mg/kg, 1100 mg/kg (male), 1200 mg/kg (female), 1010 mg/kg and 2200 mg/kg (HSDB (2005))). 4 of 7 LD50 values correspond to Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >2000 mg/kg for rats (ACGIH (2001)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. As relevant information, a LC50 value was >0.86 mg/L for rats (ACGIH (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	There is a report that the substance was a very slight dermal irritant in a rabbit test (ACGIH (2001)). Additionally, there is a result of no irritating in a rabbit skin irritation test (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (Journal of Pesticide Science vol. 12, No. 1) (1987)) and a report that single and repeated patch tests in humans showed no irritation (HSDB (2005)). Based on these information, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	There was a report that the substance was a very slight eye irritant in a rabbit test (ACGIH (2001)). Additionally, there is a report that no effect on the conjunctiva or cornea was observed during the 7-day observation period in a rabbit eye irritation test (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (Journal of Pesticide Science vol. 12, No. 1) (1987)). Based on these information, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	There are reports of "not sensitizing" in a guinea pig test (ACGIH (2001), Pesticide safety information (Japan Crop Protection Association) (List open for the public) "Journal of Pesticide Science vol. 12, No. 1" (1987)). In addition, sensitizing potential was not observed in human patch tests (HSDB (2005)). The substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in a mouse dominant lethal test by oral administration (in vivo heritable mutagenicity test) (IRIS (1995)) and a Chinese hamster spermatogonium chromosomal aberration test (in vivo germ cell mutagenicity test) (IRIS (1995)), the substance was classified as "Not classified". As relevant information, there is a report of a negative rat hepatic cell unscheduled DNA synthesis test (in vivo somatic cell genotoxicity test) (EPA RED (access on Apr. 2009)). From in vitro mutagenicity tests, there is a report of a negative Ames test (Pesticide safety information (Japan Crop Protection Association) (Journal of Pesticide Science vol. 12, No. 1 (1987)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classification of "A4" in ACGIH and D in EPA (1986), the substance was classified as "Not classified". In 2-year oral carcinogenicity tests in rats and mice, there were no evidences of carcinogenicity and there were no increases in tumor incidence (ACGIH (2001), EPA RED (access on Apr. 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Not classified	- -	-	-	In a three-generation reproduction feeding test in rats, there was no reproductive toxicity or general toxicity (ACGIH (2001)). In a two-generation reproduction test in rats, decreased body weight gains and hypertrophy of hepatocytes were observed but the substance is considered not to affect sexual function or fertility because of a lack of report for these effects in the test report (EPA RED (access on 4 2009)). There are two developmental toxicity tests for both rats and rabbits (EPA RED (access on 4 2009), Pesticide safety information (Japan Crop Protection Association) (List open for the public) (Journal of Pesticide Science vol. 12, No. 1 (1987)). Reduced maternal body weight gains were observed and in one rabbit test, an increased incidence of abortions was observed in the high dose group. No fetal developmental toxicity including teratology was observed except for reduced ossification and skeletal variations. It is clear from the two rat reproduction tests that the substance has no reproductive toxicity effects. It is clear from the two rat and the two rabbit developmental toxicity tests that the substance has no developmental toxicity effects. The substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	There is a report that no pathological changes in any specific organ were observed at rat oral LD50 test (male: 2200 mg/kg, female: 2345 mg/kg) (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (Journal of Pesticide Science vol. 12, No. 1) (1987)). However, classification was not possible since effects at the upper limit (2000 mg/kg) of guidance value range were not clear.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 13-week feeding test in rats (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (Journal of Pesticide Science vol. 12, No. 1) (1987)), no significant adverse effects were observed at dose levels up to 1500 ppm (75 mg/kg/day). In a 2-year feeding test in dogs (EPA RED (access on Apr. 2009)), increased relative liver weight and changes in liver function (increased SGOT and SGPT levels, increased alkaline phosphatase, increased total protein, etc.) were noted at the high dose level of 1500 ppm (approximately 55 mg/kg/day). In a 2-year feeding test in rats (EPA RED (access on Apr. 2009)), toxicity along with pathological changes in the liver were noted at the high dose level of 300 ppm (14.3 - 20.4 mg/kg/day). These data were not used as the basis of classification since the degree of changes in liver function is unknown and detailed pathological lesions in the liver are not reported. In a 3-week inhalation test in rats at dose levels of 0.031 - 0.720 mg/L/6h (90-day equivalence: approximately 0.0071 mg/L/6h/day), there were no toxic effects (ACGIH (2001)). In 3-week dermal tests in rats and rabbits at a dose level of 1000 mg/kg/day, no significant toxic findings were reported. Since the exposure period for the rat inhalation and rat/rabbit dermal tests was only 3 weeks and the adequacy of the test design is questionable, classification was not possible with any exposure route.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 72h-ErC50 = 0.039 mg/L for algae (Pseudokirchneriella subcapitata) (Test for the Ecological Effect of Chemical Substances (Ministry of the Environment), 1999)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (BIOWIN).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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