NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	22224-92-6
Chemical Name	N-Isopropylaminophosphoric acid ethyl(3-methyl-4-methylthiophenyl)ester, (Fenamiphos)
Substance ID	m-nite-22224-92-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Water solubility is 0.03 g/100 mL (ICSC (1998)), and the substance is stable against water.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance contains oxygen (but not fluorine or chlorine) which is chemically bonded to atoms (phosphorus) except carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	LD50 values are 2.4, 6.0, 6.1, 8.1, 9.6, 17.2 and 19.4 mg/kg (JMPR 929 (1997)), one value corresponds to Category 1 and six values correspond to Category 2. The substance was classified into Category 2 since 6 of 7 LD50 values are in this category.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	LD50 values are 72, 73, 84, 92, 154 and 500 mg/kg for rats (JMPR 929 (1997)), five values correspond to Category 2 and one value corresponds to Category 3 and the substance was classified into Category 2. LD50 values are 179 and 225 mg/kg for rabbits (JMPR 929 (1997)), the values correspond to Category 2 and 3, respectively and the substance was also classified into Category 2 based on the lower value. Since the categories in both species are same, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a LC50 (4h) value of 0.091 - 0.100 mg/L for rats (JMPR 929 (1997)), the substance was classified into Category 2. Since there is a report of aerosols, the classification criteria for dust was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a result of "minimal irritation" and an average PII (primary irritation index of skin: 0.42) following 24-hour application (JMPR 929 (1997)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, results of "not a primary irritant" (JMPR 929 (1997)) and "only slightly irritant" (PATTY (5th, 2001)) are also reported.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Moderate irritation was noted in a rabbit skin irritation test with the substance. Maximum average score within 24-hour post application was 31.3 and all symptoms were resolved within 240-hour in this test (JMPR 929 (1997)). Since the data were considered to correspond to 30 - 80 of AOI (acute ocular irritation index), the substance was classified into Category 2A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	In a guinea pig maximization test, the positive rate was reported to be 22% (less than 30%) (JMPR 929 (1997)). In another guinea pig maximization test, there is a report that fenamiphos did not induce contact dermatitis or delayed-type allergy (PATTY (5th, 2001)). Based on the data, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in a mouse dominant lethal test (in vivo heritable germ cell mutagenicity test) (JMPR 300 (1974), PATTY (5th, 2001)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test (NTP DB (access on May. 2009)), a negative CHO cell forward mutation test (PATTY (5th, 2001)), a positive human lymphocyte chromosomal aberration test (PATTY (5th, 2001)) and a negative chromosomal aberration test (PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classification of "A4" in ACGIH (ACGIH (2001)), the substance was classified as "Not classified". There was no evidence of carcinogenicity in a 2-year feeding test in rats and a 20-month feeding test in mice (PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In 2-generation and 3-generation oral reproductive tests in rats, there were no adverse effects on reproduction or fetal development (PATTY (5th, 2001), JMPR 929 (1997)). However, in a developmental toxicity test in rabbits by oral administration during the organogenesis period, an increase in the incidence of skeletal malformation (sternal fusion), fetal death and late resorptions were observed at dose levels in which general toxicity such as decreased maternal body weight gain was observed (ACGIH (2006)). Based on the data, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	After oral administration to rats, cholinergic signs such as muscle fasciculations, convulsions, impairment of motor coordination and laboured breathing, were observed with depression of erythrocyte cholinesterase activity at a dose level of 1.5 mg/kg bw (JMPR 929 (1997)). Based on the data, the substance was classified into Category 1 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	In 3-month feeding tests in rats and dogs, cholinergic signs (muscle fasciculations etc.) were observed at 32 ppm (1.6 mg/kg bw) and 18 ppm (0.45 mg/kg/day), respectively. Plasma and erythrocyte cholinesterase activities were statistically significantly reduced in both species (JMPR 929 (1997)). Since these symptoms were caused by overstimulation of the nerve fiber receptor with cholinesterase inhibition that is characteristic of organophosphorus compounds, the substance was classified into Category 1 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 48h-EC50 = 0.0019 mg/L for Crustacea (Daphnia magna) (Hazard Assessment Report (CERI, NITE), 2008).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1 since its acute toxicity is Category 1 and it is estimated not to be rapidly degradable (BIOWIN).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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