NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2227-17-0
Chemical Name	Dienochlor
Substance ID	m-nite-2227-17-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available. Besides, there is information that it is non-corrosive under dry conditions (HSDB (2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on LD50 values for rats of 3,160 mg/kg (HSDB (2003)), > 20,000 mg/kg (males), and > 30,000 mg/kg (females) (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 3,160 mg/kg for rabbits (HSDB (2005)) and an LD50 value of > 5,000 mg/kg for rats (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Data are lacking. Besides, as List 3 data, it is reported that LCLo by 4-hour exposure was > 0.425 mg/L for rats (RTECS (2005): the original article, National Technical Information Service (Springfield, VA 22161): OTS0537028). However, because the category cannot be determined, the classification is not possible. Because the test concentration was above the saturated vapour pressure concentration (0.0019 mg/L), it was regarded as a test on dust.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (corresponding to Category 3 in UN GHS classification) because, in a test in which 0.5 g of 50% wettable powder was applied to the rabbit skin for 24 hours, slight erythema and edema were observed by five days after the application, but these disappeared six days after the application, and it was judged as slightly irritating (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)). Besides, there is also described that this substance is not a skin irritant in humans (HSDB (2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It was classified in Category 2B because it is reported that slight irritation was observed in a test in which 3 mg was applied to the rabbit eye, but it disappeared by day 6 (HSDB (2005)), and in a test in which 100 mg of 50% wettable powder was applied to the rabbit eye, slight conjunctival irritation at 1 hour after the application and slight irritative changes also in the cornea and iris in addition to the conjunctiva after 24 hours were found, and about two weeks were needed for recovery, but it was judged as slightly irritating. Besides, it is also described that this substance is a slight eye irritant in humans (HSDB (2005)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that 50% wettable powder was not sensitizing in a skin sensitization test with guinea pigs (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)), but it is List 2 data, and the details on the test method and test results (such as positive rate) are unknown. Therefore, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a chromosomal aberration test with bone marrow cells after oral administration to mice (in vivo somatic cell mutagenicity test) (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)). Besides, as for in vitro tests, in Ames tests, there are reports that it was positive in the TA100 strain (HSDB (2005)), false-positive only in the TA100 strain (not statistically significant but slight increase), and negative in the other strains (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In developmental toxicity tests by oral administration to pregnant rats and pregnant rabbits during the organogenesis period, maternal animals showed slightly reduced weight gain at the high doses (rats 50 mg/kg, rabbits 40 mg/kg) in both animal species, but no changes were observed in developmental parameters (such as the number of implantations, embryonic mortality, and the number of live fetuses), the incidence of malformations, and the growth of fetuses (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)). No adverse effects on the development of were found offspring from the results, but it was impossible to judge the sexual function and fertility of parent animals because there are no data on exposure before mating. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is reported that maximum no-effect level was judged to be 320 ppm (males: 38.3 mg/kg/day, females: 44.8 mg/kg/day) in a subacute toxicity test by 3-month diet administration to mice (0, 20, 80, 320, 1,280 ppm), at the highest dose of 1,280 ppm (males: 153.2 mg/kg/day, females: 179.2 mg/kg/day), four each of males and females died during the dosing period, and histopathological examination of dead animals revealed fatty degeneration in the liver, anisokaryosis in hepatocytes, Kupffer cell swelling, etc. and increased activities of ALP and GPT (males only) (Pesticide safety information (Japan Crop Protection Association), Japanese Journal of Pesticide Science Vol. 15, No. 3 (Pesticide Science Society of Japan, 1990)). From the results, effects on the liver were suggested, but the dose (1,280 ppm) was above the guidance value range, and the effects are unknown around the upper limit of the guidance values. Therefore, it was classified as "Classification not possible."	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.050 mg/L for fish (Oncorhynchus mykiss) (AQUIRE, 2012).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it corresponds to Category 1 in acute toxicity for fish (AQUIRE, 2012).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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