NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	22398-80-7
Chemical Name	Indium phosphide
Substance ID	m-nite-22398-80-7_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Classified into Not classified since the substance is considered to be stable against water from the information that it slightly dissolves in acid solutions (Lide (88th, 2008)) though it contains metals (In).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Inorganic compounds containing no oxygen and halogen atoms	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on no mortality at 5000 mg/kg in mice (NTP TR499 (2001)), the substance was classified into "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	In a mouse peripheral blood micronucleus test by 90-day inhalation exposure (in vivo somatic cell mutagenicity test), no significant increase in micronucleated normochromatic erythrocytes was noted in males or females. A significant increase in micronucleated polychromatic erythrocytes was observed in the highest dose group of females, but this effect was not observed in any group of males (NTP DB (access on Oct. 2009)). Classification was not possible.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Based on the classification of "Group 2A" in IARC (IARC 86 (2006)), the substance was classified into Category 1B. In rat and mouse 105-week inhalation tests (concentrations of 0, 0.03, 0.1 or 0.3 mg/m3, animals in the 0.1 and 0.3 mg/m3 groups were exposed for approximately 22 weeks and evaluated at 2 years), there was clear evidence of carcinogenic activity in both rats and mice based on increased incidences of benign and malignant neoplasms of the lung and pheochromocytoma of the adrenal gland in rats, and increased incidences of benign and malignant neoplasms of the lung and liver in mice (NTP TR499 (2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1) to (3), classification was not possible since there was no information on effects of mating on fertility nor developmental effects of exposure during gestation, although there were reports of hazardous effects on the reproductive organs. [Reference Data, etc.] (1) In a 14-week inhalation exposure test with rats and mice, at 100 mg/m3, effects on male and female reproductive organs (decreased weights of testes/epididymis, presence of degenerating cells from testicular germinal epithelium within seminiferous tubules/epididymis (rats), ovarian and uterine atrophy and longer estrous cycles (mainly mice)) were observed, but the effects on female reproductive organs (markedly in mice) were caused at doses at which deaths occurred and were considered as secondary effects (CLH Report (2009), ECHA RAC Opinion (2010), NTP TR499 (2001)). (2) In a test with male hamsters in which an exposure by intratracheal instillation (3 mg/kg, twice/week, 8 weeks) was followed by an 88-week observation, effects on male reproductive organs (decreased weight of testes and epididymis, decreased sperm count, histopathologic alterations of the seminiferous tubules) were observed at the end of exposure and also at weeks 16 and 64 after the last exposure. The effects tended to reverse at the end of the observation period (after 88 weeks) (CLH Report (2009), ECHA RAC Opinion (2010)). (3) In a toxicokinetic experiment with rats by repeated inhalation exposure to this substance, evidence of indium accumulation in testes was observed (CLH Report (2009), ECHA RAC Opinion (2010)). (4) In the EU, it was classified in Repr. 2 (EU CLP Classification Results (Accessed Oct. 2021)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Based on a report that there was no deaths or toxic effects in rats administered orally at dose levels of 1000 - 5000 mg/kg (NTP TR499 (2001)), the substance corresponds to "Not classified" with oral exposure. Classification was not possible due to lack of data with other exposure routes (inhalation and dermal). In a rat intratracheal test, strong inflammatory lesion in the lung was observed at dose levels of 1 mg/kg and higher, and inflammatory lesion, alveolar epithelial desquamation and intraalveolar effusion in the lung were observed at a dose level of 62.0 microg/kg (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2007)). These findings were not used as the basis of classification due to intratracheal exposure.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory system, hematopoietic system), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	In 14-week inhalation tests in rats and mice (0.0011 - 0.1 mg/L, dusts), the lungs of all exposed animals had discoloration and were enlarged, inflammatory and proliferative lesions consisted of alveolar proteinosis, chronic inflammation, interstitial fibrosis and alveolar epithelial hyperplasia occurred (the effects in rats were more serious than those in mice). The substance caused inflammation at the base of the epiglottis of the larynx and hyperplasia of the bronchial lymph nodes (NTP TR499 (2001)). In addition, exposure to the substance affected the circulating erythroid mass, and induced a microcytic erythrocytosis consistent with bone marrow hyperplasia and hematopoietic cell proliferation of the spleen (NTP TR499 (2001)). Since these findings were observed at exposure concentrations within the guidance value range for Category 1 or 2, the substance was classified into Category 1 (respiratory system, hematopoietic system). Hepatocellular necrosis was suggested by increased serum activities of alanine aminotransferase and was confirmed microscopically at a concentration of 0.1 mg/L (within the guidance value range for Category 2) in the 14-week inhalation test in rats, therefore, the substance was classified into Category 2 (liver). Additionally, there is a report that the substance caused obvious testicular damage in a test where hamsters were observed for approximately two years following intratracheal instillations of 3.0 mg/kg. Decreases in male reproductive organ weight and caudal sperm count, and severe histopathologic changes in the testes were also found (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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