NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2243-62-1
Chemical Name	1,5-Diaminonaphthalene
Substance ID	m-nite-2243-62-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It is conceivable that it does not to ignite at normal temperatures from an ignition point of 580 degrees C (ICSC (1999)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	An organic compound does not contain oxygen, fluorine, or chlorine.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Reported LC50 values of 2100 mg/kg for male rats and 634 mg/kg for female rats (IUCLID (2000)) correspond to "Not classified" and Category 4 respectively, Because the higher level male data was adopted, it was classified in Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of > 2000 mg/kg for rats (IUCLID (2000)) and a death case at 2000 mg/kg, it was classified as "Not classified" in JIS classification (Category 5 or "Not classified" in UN GHS classification).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	From an LC50 value of >= 5.27 mg/L/4h for rats [OECD TG 403; GLP] (IUCLID (2000)), it was classified as "Not classified." Besides, a reference value of dust was applied due to the information that this substance was administered in the dust (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	On the basis that a semi-occlusive test (OECD TG 404) applied 500 mg test substance to rabbit skin for 4 hours resulted in irritation scores of 0 in all animals at all observation points and no primary irritant effects (BUA Report 115 (1995)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	On the basis that a test applied 100 mg to rabbit eyes and washed after 24 hours (OECD TG 405) resulted in irritation scores of 0 in all animals at all observation points and no irritant effects on the eyes (BUA Report 115 (1995)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	A maximization test in guinea pigs (OECD TG406, GLP) reported sensitizing from dose-dependent positive rates of 45% (9/20), 50% (10/20), and 20% (4/20) in a challenge in test substance concentrations of 50%, 25%, and 5% respectively. (BUA Report 115 (1995), IUCLID (2000)) It remarked that this substance must be regarded as potential contact allergen for humans as a result (BUA Report 115 (1995)). Therefore, it was classified in Category 1. Besides, it is designated as Sh in MAKBAT (MAK/BAT (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	A DNA covalent binding test using liver after oral administration in rats (GLP compliance) (in vivo somatic cell genotoxicity test) reported a negative (IUCLID (2000)), but the classification is not possible due to no other data on in vivo tests using germ or somatic cells. Besides, as in vitro tests, an Ames test (NTP DB (Access on Dec. 2011), IUCLID (2000)), a chromosomal aberration test using V79 cells, and an SCE test (IUCLID (2000)) reported positive results and HGPRT with V79 cells and a UDS test with primary rat hepatocytes reported negative results.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	From Group 3 classification in an IARC carcinogenicity evaluation (IARC Suppl. 7 (1987)), it was classified as "Classification not possible." Besides, a 2-year oral administration test in rats and mice reported a significant increase in the incidence of adenomas and carcinomas of the clitoral gland in rats and dose-dependent significant increase in the incidence of carcinomas of the thyroid gland, hepatocellular carcinomas and bronchiolar or alveolar adenomas in mice. (IARC 27 (1982)). It is classified in Carc. Cat. 3; R40 in EU classification (EC-JRC (ESIS) (Access on Dec. 2011)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	An oral administrated developmental toxicity test in pregnant rats during an organogenetic period (OECD TG414: GLP) reported no adverse effects on fetal development except a slight decrease in body weights in fetuses in the medium-dose and high-dose groups in which decreased weight gain in maternal animals was shown. (IUCLID (2000)) But it was classified as "Classification not possible" because effects on sexual function and fertility in administration before mating in parent animals are unknown due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (narcotic effects)	Warning	H371 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	From reported LD50 values of 2100 mg/kg in males and 634 mg/kg in females and information on toxic signs such as anesthetization and general malaise both in males and in females in an acute oral toxicity test in rats (IUCLID (2000)), it was classified in Category 3 (narcotic effects). In addition, the females showed unkempt coat, a decrease in body weights, and a death case at a dose corresponding to Category 2 in the guidance values, but the specific target organ cannot be determined. Therefore, it was classified in Category 2 (systemic toxicity).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In an 8-week diet administration test in rats and mice (test concentrations: 0, 0.03, 0.1, 0.3, 1.0, 3.0 %), deaths in groups at 0.3% above the range in Guidance values (converted to a 90-day equivalent: 264 mg/kg/day) or higher in both species and deaths in the group at 0.03% (26.5 mg/kg/day) only in female mice were reported. (NTP TR 143 (1978)) The deaths observed in female mice in the 0.03% group are unlikely to be dose-related because there were no deaths at a higher dose of 0.1% and it was regarded as no significant association between dosage and mortality in a 103-week diet administration test in mice (test concentrations: 0.1, 0.2 %) (NTP TR 143 (1978)). And only a decrease in body weights was reported without details as other effects. Therefore, it was classified as "Classification not possible."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 72-hour EC50 (growth rate) = 2.1 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, an average degradation rate by BOD: 0% (J-CHECK, 1988)), and 72-hour NOEC (growth rate) = 0.34 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2018)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (not readily degradable, an average degradation rate by BOD: 0% (J-CHECK, 1988)), and 48-hour EC50 (immobile) = 3.8 mg/L for crustacea (Daphnia magna). From the above results, it was classified in Category 2.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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