NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2269-22-9
Chemical Name	Aluminium tri-sec-butoxide
Substance ID	m-nite-2269-22-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Although flash point of the substance is 26 degC (Ullmanns (E) (6th, 2003)), since its flash point reported 26 degC (closed-cap) by Aldrich MSDS (Access on Nov. 2010), it was estimated which is >= 23 degC and <= 60 degC, this substance is classified into Category 3.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Although the substance is an organic compound containing metal (Al), there is description that "The substance is easily hydrolyzed producing aluminum hydroxide and 2-butanol" (Ullmanns (E) (6th, 2003)). It was assumed that it produces combustible liquid and a small amount of flammable gas, and, this substance is classified as "Not classified".	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Classification not possible	- -	-	-	Although the substance is an organic compound containing oxygen which is chemically bonded to the elements other than carbon or hydrogen, due to lack of additional data, classification is not possible.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data were available. The substance is easily hydrolyzed into aluminum hydroxide and 2-butanol (Ullmanns (E), 6th (2003)). [Refer also to classification results of 2-butanol (ID 913).]	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). As relevant information, as for aluminum hydroxide, no maternal toxicity, embryo/fetal toxicity or teratogenicity were reported in the oral study in mice administered during the gestation period (66.5 - 266 mg/kg/day), and no toxic effects were reported in the oral study in mice administered during the gestation period (57.5 mg/kg/day). Reduced fetal body weight and increased skeletal variations were reported in the oral study in rats administered during the gestation period (384 mg/kg/day). It was also reported that in the oral study in rats administered during the gestation period (192 - 768 mg/kg), the NOEL was 768 mg/kg/day (the aforementioned, JECFA FAS 58 (2007)). As for the current classification for 2-buthanol was "In the two-generation reproduction study by drinking water in rats, there was no effect on reproductive potential, only the minimum influence (growth retardation of pups) was observed. On the other hand, in the inhalation study in rats exposed during the gestation period, reduction of live newborns and increase of embryo absorption was observed at the dose in which toxic effects on dams were observed (PATTY, 4th (1994), ACGIH (2002), DFGOT vol.19 (2003)). It was suggested that the substance may have adverse effects on fertility or embryo. The substance was considered as Category 2."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). No data were available for aluminum hydroxide. While as for the current classification for 2-buthanol, it was described as follows. "Inhalation by high concentration exposure levels to mice caused the symptoms of depression of central nervous system (DFGOT vol.19 (2003)). By inhalation exposure, anesthetic actions were seen in humans and mice (EHC 65 (1987), and in rats and mice (PATTY, 4th (1994), DFGOT, vol.19 (2003)). From the description (ACGIH (2002), DFGOT, vol.19 (2003), Society for Occupational Health, Recommendation of Occupational Exposure (1986)) that nasal and throat were stimulated in humans in high exposure levels, the substance was considered to be respiratory irritant. Thus the substance was concluded as Category 3 (drowsiness and dizziness) and Category 3 (irritation to respiratory organs)."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data were available. The substance is easily hydrolyzed, and produces aluminum hydroxide and 2-buthanol (Ullmanns, 6th (2003)). As relevant information on aluminum hydroxide, it was described that this was used as a pharmaceutical drug (antacid), and this might cause constipation, nausea, vomiting as its side effects (Handbook of Japanese Pharmaceutical Drugs (2010), Merck Manual, vol. 18 (2006)). It was also described that through a long-term treatment, this might cause aluminum encephalopathy or aluminum osteopathy (Handbook of Japanese Pharmaceutical Drugs (2010)). As for the animal experiments, no effects were reported on clinical signs, food and water consumption, growth, hematological and serum analyses, tissue and plasma concentrations of aluminum, histopathology in the 28-day oral dose study in rats (converted dose level as that of 90-day study: 407 mg/kg/day) (EHC, 194 (1997)). It was also reported that in the oral dose study in rats (17 - 29 mg/kg/day) the animals showed significant impairment of growth at 3 - 4 weeks of administration, and rachitic changes occurred in the bone (HSDB (2009)). As for the current classification for 2-buthanol, it was written as "No data available. Classification not possible."	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2010	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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