NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2425-06-1
Chemical Name	(N-(1,1,2,2-Tetrachloroethylthio)-1,2,3,6-tetrahydrophthalimide); Captafol
Substance ID	m-nite-2425-06-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Not ignite spontaneously on coming into contact with air at normal temperatures	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen and chlorine and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	From description that rat LD50 values: 2500 to 6200 mg/kg (JMPR (1969), PIM 097 (1990), IARC 53 (1991)), 5000mg/kg (JMPR, 1969), and 2500 to 6200 mg/kg (AI exchange: 2000 to 4960 mg/kg) about 80% Wettable Powder, statistics calculation was done. It was set as Category 5 based on the calculated value 3067mg/kg.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the description that >15400mg/kg (AI reduced value: >12321mg/kg) about rabbit LD50 value: 15400mg/kg (IARC 53 (1991)) and 80% Wettable powder), it was set as the outside of Category	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was set as Category 2 by description that there was moderate irritation to the skin of the rabbit (ACGIH (7th, 2001)), and by description that many stimulative and allergic examples of contact dermatitis development of symptoms were reported in the agriculture and forestry pursuers of handling KYAPUTAFORU in Kumamoto, other domestic areas, and New Zealand (PIM 097 (1990), ACGIH (7th, 2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is the description that in the test applied to the eye of the rabbit, corneal opacities, irritation responses to iris and conjunctival continued 21 days after the application (PIM(2005)), and the description that there is a report in humans occupational exposure causes conjunctivitis and eyelid edema (PIM 097 (1990). Based on these description (in the ACGIH (7th, 2001)), it was set as Category 2A.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	It was classified as Category 1 based on the description of PATTY (4th, 1994) and ACGIH (7th, 2001) that "Captafol has skin sensitizing effect and respiratory sensitization effect in human."	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was categorized as Category 1 based on the descriptions in PIM 097 (1990), IARC 53 (1991), PATTY (4th, 1994) and ACGIH (7th, 2001) that many cutaneous sensitization properties and optical allergic reactions were acknowledged in the farmers of Japan, silviculture workers of New Zealand, and the researchers of the chemistry maker laboratories, and the descriptions of PATTY (4th, 1994) and ACGIH (7th, 2001) that "Captafol has cutaneous sensitizing property and respiratory sensitizing property in human."	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 1B	Danger	H340	P308+P313 P201 P202 P280 P405 P501	Although the result of dominant lethal test on mouse, an in vivo generation mutagenicity test on germ cells, was negative (JMPR (1997) and IARC 53 (1991)), the results of the dominant lethal test on rats, both IP injection and oral administration, were weak positivities (IARC 53 (1991)). So it was classified as Category 1B. In addition, it is positive in the test systems which does not include metabolic activation system in the chromosomal aberration test and micronucleus test which are in vitro mutagenicity test using somatic cells (IARC 53 (1991)).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It was classified into A4 in ACGIH (7th, 2001), but it was classified into 2A in IARC 53 (1991) and was classified into the category 2 in EU (an evaluation year was unknown). So it was considered as Category 1B, prioritizing evaluation of IARC.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Since malformation and toxicity was not observed of fetuse in rat teratogenicity test with the dose affecting maternal, and only the minimum effect was observed in the fetal in the rat two-generation reproduction study at the dose affecting maternal, it was considered as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, urinary bladder), Category 2 (liver)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	Based on descriptions that in study of dogs, it was observed that degeneration of the transitional-epithelium cell of the kidney and the bladder with the oral dosage of the guidance value range of Category 1 in the 12-month (IRIS, 1987 evaluation), and that in the chronic toxicity study of a rat it was observed that organization injury, such as degeneration of hepatocytes of liver and renal tubules at the dosage of the guidance value range of Category 2 in the feeding administration during two years (JMPR, 1977;IRIS, and 1987, and PATTY, 4th, and 1994), it was classified into Category 1 (the kidney, bladder) and Category 2 (liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 96-hour LC50=20.6microg/L of fishes (Rainbow trout) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.8(PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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