NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2431-50-7
Chemical Name	2,3,4-Trichloro-1-butene
Substance ID	m-nite-2431-50-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It corresponds to Category 4 from a flash point of 63 deg C [closed-cup] (ICSC (2004)) > 60 deg C and <= 93 deg C.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) in the molecule, and there is information that explosive reactions may occur when there is a sudden thermal action (Hommel (1996)). Therefore, it may be applicable to the hazards of the higher precedence than Type G, but the classification is not possible due to no data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 530 deg C (GESTIS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	It is described that steel and aluminum are unsuitable as a container (GESTIS (Access on June. 2012)), but the classification is not possible due to no test data on the corrosion rate.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values for rats of 341 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)) and 351 mg/kg (SIDS (Access on June 2012)). Besides, it was classified in Xn; R22 in EU classification (EC-JRC (ESIS) (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was classified in Category 2 because a report on an LC50 value by 4-hour exposure of > 1.722 mg/L (264 ppm) for rats (SIDS (Access on June 2012)) corresponds to Category 2 or a less hazardous category, and it was classified in T; R23 in EU classification (EC-JRC (ESIS) (Access on June 2012)). Besides, because the test concentration was lower than 90% of the saturated vapour pressure concentration (15.0 mg/L), a reference value of gas was applied.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because irritation was observed in a test in humans (SIDS (Access on June 2012)), and it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was classified in Category 2 because it is described that contact with vapour causes eye irritation and lacrimation in humans (SIDS (Access on June 2012)), and it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on a negative result in a dominant lethal test by 5-day inhalation exposure in rats (in vivo heritable germ cell mutagenicity test) (IUCLID (2000), SIDS (Access on June 2012)). Besides, as for in vitro tests, it was reported to be positive in an Ames test (SIDS (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It is reported that in a 25-month inhalation exposure test with rats, out of 110 animals in the high dose group (after 12-week exposure to 2 ppm/6 hours, the dose was changed to 1.5 ppm//6 hours), 27% of males and 18% of females developed nasal neuroepithelioma and 3% of males developed malignant nasal neurinoma (SIDS (Access on June 2012)). This substance was classified in Category 2 because it was classified in Category 2 by Deutsche Forschungsgemeinschaft (MAK/BAT (2011)) and Carc. Cat. 3; R40 by the EU (EC-JRC (ESIS) (Access on June 2012)), and it was taken into account that nasal neuroepithelioma was an extremely rare and highly malignant tumor.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test by inhalation exposure in pregnant rats during the organogenesis period, reduced weight gain was observed in maternal animals in the high dose group, but there were no malformations in fetuses (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)). And as a result of 5-day inhalation exposure in male rats to investigate fertility, decreases in food consumption and body weight were found during inhalation, but there were no adverse effects on gestation index, the number of implantations, postimplantation loss, etc. after mating with females (IUCLID (2000)). From the above reports, no adverse effects on sexual function/fertility and the development of offspring were seen, but exposure effects on sexual function/fertility were obtained only in males, and there were no female data. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (respiratory tract irritation) because it was irritating to the eyes, skin, and respiratory tract in humans, and it caused cough, sore throat, lethargy, nausea by inhalation (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), and inhalation exposure caused a decrease in respiratory rate (RD50 = 58.1 ppm) in rats (IUCLID (2000)). Besides, it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There is a report on hyperplasia and metaplasia of the respiratory epithelium at 0.017 mg/L in a 13-week inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), hyperplasia and metaplasia of the epithelium in the nasal cavity, bronchus, and lung and increased lung weight at 13 mg/m3 (converted guidance value: 0.004 mg/L) and 54 mg/m3 (converted guidance value: 0.016 mg/L) in a 4-week inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)), and inflammatory changes in the olfactory epithelium at 0.001 mg/L, dyspnea and findings of chronic respiratory disease, increased lung weight, increased mortality, etc. at 0.01 (0.013) mg/L in a 25-month inhalation exposure test with rats (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)). Because all the above findings were observed within the guidance value range for Category 1, it was classified in Category 1 (respiratory system). Besides, it is described that long-term or repeated exposure may have effects on the respiratory tract and may result in tissue lesions in humans (Environmental Risk Assessment for Chemical Substances vol. 9 (Ministry of the Environment, 2011)).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.48 mg/L for fish (Lepomis macrochirus) (SIDS, 2001).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2001)), and it corresponds to Category 1 in acute toxicity for fish (SIDS, 2001).	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2012	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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