Item | Information |
---|---|
CAS RN | 2439-35-2 |
Chemical Name | 2-(Dimethylamino)ethyl acrylate |
Substance ID | m-nite-2439-35-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Category 4 |
Warning |
H227 | P370+P378 P210 P280 P403 P501 |
It corresponds to Category 4 from a flash point of 61.7-68 deg C [closed-cup] (SIDS (2003)), which is > 60 deg C and <= 93 deg C. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Type G |
- |
- | - | There is a chemical group associated with self-reactive properties (unsaturated bond, acrylate) present in the molecule, but commercial products are classified in Type G because there are classified in Division 6.1 in UNRTDG (UN3302, 16th, 2009) and are stabilized by hydroquinone derivatives, etc. (IMDG (2010)) (e.g., hydroquinone monomethyl ether (Chemical Substance Hazard Data (CERI, 2001))). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 209 deg C (SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
It was classified in Category 4 based on an LD50 value of 455 mg/kg for rats (OECD TG401, GLP) (SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
Among two LD50 values for rats of 419 mg/kg and 891 mg/kg (both, OECD TG402, GLP) (SIDS (2003)), and an LD50 value of 50-200 mg/kg for rabbits (SIDS (2003)), based on data in rats according to the test guideline and GLP, it was classified in Category 3. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Both two LC50 values for rats of 0.927 mg/L/1 hour (158 ppm/1 hour = 83 ppm/4 hours) [OECD TG403, GLP] and 0.22 mg/L/4 hours (37.6 ppm/4 hours) (SIDS (2003)) correspond to Category 1. Besides, because the test concentrations were lower than 90% of the saturated vapour pressure concentration (671 ppm), the reference value of gases was applied as a vapour with little mist. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified in Category 2 based on an LC50 value of 0.066 mg/L/4 hours for rats [OECD TG403, GLP] (SIDS (2003)). Besides, the reference value of mists was applied because it is described that the test was conducted on aerosols (SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a test in which 0.5 mL of the undiluted test substance was applied to six rabbits for 4 hours (OECD TG 404), corrosivity was seen in all the animals, and the primary dermal irritation index (PDII) was 8 (SIDS (2003)). Therefore, it was classified in Category 1. Besides, other than the above, results of two Draize tests with rabbits were reported, PII was 8 and 7.6, and it was assessed as corrosive in both (SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
In a test in which 0.1 mL of the undiluted test substance was instilled into the eyes of two rabbits, and the eyes were rinsed 4 seconds after the instillation, both the animals displayed corneal, iris, conjunctival lesions within 1 hour, and it was judged as corrosive (SIDS (2003)). Therefore, it was classified in Category 1. Besides, it was also reported to be corrosive in another Draize test with rabbits (SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Category 1A |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In a guinea pig maximization test (OECD TG406, GLP), after induction by intradermal administration of 0.5% of this substance, it was judged as sensitizing with a positive rate of 100% (20/20) (SIDS (2003)). Therefore, it was classified in Category 1A. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | It was classified as "Not classified" based on a negative result in a micronucleus test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (OECD TG474, GLP) (SIDS (2003)). Besides, as for in vitro tests, it was reported to be positive in an Ames test and chromosomal aberration tests with CHL/IU cells or human lymphocytes (Toxicity Testing Reports of Environmental Chemicals (Chemicals Investigation Promoting Committee)(1997), SIDS (2003)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In a developmental toxicity test by oral administration to pregnant rats during the organogenesis period (OECD TG414, GLP), an increase in post-implantation loss and an increase in malformations and anomalies such as dwarf fetuses, adactyly, cleft palate, hydrocephaly, and testicular ectopia were seen at a dose (100 mg/kg/day) where maternal animals showed general toxicity, including death (SIDS (2003)). Therefore, it was classified in Category 2. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (4-100 mg/kg/day) (OECD TG422, GLP), transiently reduced weight gain and decreased food consumption in paternal animals and death of two maternal animals were observed in the 100 mg/kg group, but there were no effects on sexual function and fertility, and no changes were found in the birth or survival of offspring (JECDB (Access on Sept. 2011)). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, systemic) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
In an acute toxicity test by 4-hour inhalation (aerosol) in rats (LC50 = 0.066 mg/L) (OECD TG403, GLP), symptoms of gasping, rales, and lethargy were seen, and necropsy of dead animals revealed congestion and swelling of the lung and pulmonary edema (SIDS (2003)). Also, in an acute toxicity test by 1-hour inhalation (vapour) in rats (converted 4-hour equivalent value: LC50 = 0.486 mg/L) (OECD TG403, GLP), labored respiration and rales were observed, and at necropsy, dead animals had necrosis and purulent exudate in the nasal cavity, larynx, and trachea, and survived animals showed epithelial hyperplasia with keratinization in the larynx (SIDS (2003)). From the above, because doses were within the guidance value range for Category 1, it was classified in Category 1 (respiratory system). On the other hand, hypokinesia, sedation, piloerection, dyspnea, and tonic-clonic convulsions followed by death were found in an acute oral toxicity test with rats (80-2,000 mg/kg; LD50 = 455 mg/kg) (OECD TG401, GLP), and in an acute dermal toxicity test (200-2,000 mg/kg; LD50 = 419 mg/kg) (OECD TG402, GLP), a decrease in spontaneous activity was seen in all animals at all doses (SIDS (2003)), and the above effects were observed at doses corresponding to the guidance value range for Category 1 in both the routes. However, because it was impossible to specify the target organ, it was classified in Category 1 (systemic toxicity). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (systemic) |
Warning |
H373 | P260 P314 P501 |
In a 13-week repeated oral administration test with rats (OECD TG408, GLP), at the highest dose of 50 mg/kg/day, in addition to a high incidence of mortality, respiratory difficulties and a sign of ill health before death, and ptyalism and loud breathing in surviving animals were seen (SIDS (2003)). In histopathological investigations, effects related to the test substance were observed in the lung and forestomach for both dead and surviving animals, but it is mentioned that the lesions in the lung were caused by reflux of stomach contents (SIDS (2003)). Furthermore, it is reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422, GLP), two females died in the highest dose of 100 mg/kg (converted guidance value: about 47 mg/kg/day), congestion, hemorrhage, and edema in the lung were found, and changes in the lung were considered to be a possible cause of death, and major pathological changes were lesions in the forestomach mucosa such as thickening, ulcer, and hyperplasia (JECDB (Access on Sept. 2011)). From the above, death occurred at doses corresponding to the guidance values for Category 2, and there were lesions in the forestomach and sporadic lung disorders, which were mentioned to be a possible cause of death. However, this substance is corrosive, and lesions in the forestomach were considered to be caused by local irritation, while lung disorders occurred in dead animals, which were not sufficient to specify the target organ. Therefore, it was classified in Category 2 (systemic toxicity). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | In experimental animals, there is a report on alveolar hemorrhage and edema and congestion in the lung, which were considered likely to be an irritative effect of regurgitation of stomach contents, and death by oral administration (SIDS (2003)), and because kinematic viscosity was 1.31 mm2/s (25 deg C) (viscosity 1.23 mPa・s, density 0.94 g/cm3 (SIDS (2003))), it corresponds to Category 2 in UN GHS classification. However, because Category 2 is not used in Classification JIS, it was classified as "Classification not possible." | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.88 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2004). | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
- |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being rapidly degradable (it hydrolyzes in water to generate acrylic acid (readily biodegradable) and N,N-dimethylethanolamine (readily biodegradable) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and 72-hour NOEC = 0.025 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1996)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being rapidly degradable (it hydrolyzes in water to generate acrylic acid (readily biodegradable) and N,N-dimethylethanolamine (readily biodegradable) (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1993)), and a low bioaccumulation estimate (log Kow = 0.42 (PHYSPROP Database, 2009)), despite 96-hour LC50 = 8.49 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 3 (Ministry of the Environment, 2004)). From the above results, it was classified in Category 2. |
FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2011 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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