Item | Information |
---|---|
CAS RN | 24851-98-7 |
Chemical Name | Methyl(2-pentyl-3-oxocyclopentyl)acetate |
Substance ID | m-nite-24851-98-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | |
Sample SDS by MHLW (External link) | |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gas | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point was about 150 deg C (Closed cup) (GESTIS (Accessed Sep. 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solid | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 259 deg C (GESTIS (Accessed Sep. 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (4). [Evidence Data] (1) LD50 for rats (cis-: trans-isomer (about 10: 90)): > 5,000 mg/kg (REACH registration dossier (Accessed Oct. 2020)) (2) LD50 for rats (cis-: trans-isomer (about 10: 90)): > 10 mL/kg (> about 10,000 mg/kg) (REACH registration dossier (Accessed Oct. 2020)) (3) LD50 for rats (cis-: trans-isomer (about 30: 70)): about 10 mL/kg (about 10,000 mg/kg) (REACH registration dossier (Accessed Oct. 2020)) (4) LD50 for rats (cis-: trans-isomer (about 70: 30)): < 10 mL/kg (< about 10,000 mg/kg) (REACH registration dossier (Accessed Oct. 2020)) [Reference Data, etc.] (5) Specific gravity (20 deg C): 1.005 (REACH registration dossier (Accessed Oct. 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits (cis-: trans-isomer (about 10: 90)): > 5,000 mg/kg (REACH registration dossier (Accessed Oct. 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LC50 for rats (4 hours): > 4.93 mg/L (measured value, no dead animals) (OECD TG 403, GLP) (REACH registration dossier (Accessed Oct. 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) It is reported that in a patch test in 111 persons, no skin irritation reactions were seen by a 20% solution of this substance (cis-: trans-isomer (about 10-12%: 88-90%)) (REACH registration dossier (Accessed Oct. 2020)). (2) It is reported that in a patch test in 100 persons, no skin irritation reactions were observed by a 20% solution of this substance (cis-: trans-isomer (about 75%: 25%)) (REACH registration dossier (Accessed Oct. 2020)). (3) It is reported that in a skin irritation test with rabbits (n = 3) on this substance (cis-: trans-isomer (about 30%: 70%)) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were found in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) It is reported that in an eye irritation test with rabbits (n = 3) on this substance (cis-: trans-isomer (about 10-12%: 88-90%)) (OECD TG 405, GLP, 72-hour observation), all the animals showed conjunctival redness after 1 hour but fully recovered within 48 hours (corneal opacity score: 0/0/0, iritis score: 0/0/0, conjunctival redness score: 0/0.3/0.3, chemosis score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (4). [Evidence Data] (1) It is reported that in a patch test in 111 persons, no skin sensitization reactions were seen by a 20% solution of this substance (cis-: trans-isomer (about 10-12%: 88-90%)) (REACH registration dossier (Accessed Oct. 2020)). (2) It is reported that in a patch test in 100 persons, no skin sensitization reactions were observed by a 20% solution of this substance (cis-: trans-isomer (about 75%: 25%)) (REACH registration dossier (Accessed Oct. 2020)). (3) It is reported that in a maximization test with guinea pigs (n = 10) on this substance (cis-: trans-isomer (about 30%: 70%)) (OECD TG 406, GLP, intradermal administration: 6.25% solution), a positive rate was 0% (0/10) after a challenge with a 50% or 100% solution (REACH registration dossier (Accessed Oct. 2020)). (4) It is reported that in a local lymph node assay (LLNA) with mice (n = 5/group) on this substance (cis-: trans-isomer (about 75%: 25%)) (OECD TG 429, GLP), stimulation index (SI values) did not exceed 3 at any concentration (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (6), it was classified as "Not classified." [Evidence Data] (1) In a micronucleus test of this substance (a mixture of a cis isomer, ca. 10 to 12% and a trans isomer, ca. 86 to 88/88 to 90%) using the mouse bone marrow cells (OECD TG 474, GLP, intraperitoneal injection), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (2) In unscheduled DNA synthesis (UDS) tests with the hepatocellular from rats (OECD TG 486, GLP, intraperitoneal injection), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (3) In a bacterial reverse mutation test of this substance (a mixture of isomers with a composition ratio of 7:1) (OECD TG 471, GLP), negative results were reported (Toxicity Testing Results for Existing Chemical Substances under the Chemical Substances Control Law (2013)). (4) In an in vitro mammalian cell chromosome aberration test (OECD TG 473, GLP), negative results were reported (JECDB (2013)). (5) In a reverse mutation test of this substance (a mixture of a cis isomer, ca. 10 to 12% and a trans isomer, ca. 86 to 88/88 to 90%) (OECD TG 471, GLP), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). (6) In a gene mutation test with the L5178Y mouse lymphoma cells (OECD TG 476, GLP), negative results were reported (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) It was reported that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG422, GLP, for 42 days from 14 days before mating until the day before necropsy (males), for 41 to 46 days from 14 days before mating until day 4 of lactation (females)), at 1,000 mg/kg/day, reduced body weight gain and effects on the liver, kidney, blood system, etc. were observed in parental animals; and lower body weight on day 0 after birth was only observed in pups (Toxicity Testing Results for Existing Chemical Substances under the Chemical Substances Control Law (2013)). (2) It was reported that in a developmental toxicity study with rats dosed by gavage (OECD TG 414, GLP, days 7-20 of gestation), no developmental toxicity was observed (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1), this substance was considered to produce irritation to nasal mucous membranes at high doses near the upper limit of Category 2 and it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) It was reported that in an acute inhalation (dust/mist) toxicity test with rats (OECD TG 403, GLP, 4 hours), at 4.93 mg/L (within the range for Category 2), there was no death case, and an increase in respiratory rate, hunched posture, piloerection, wet fur, red and brown stains around the snout, and respiratory murmur in some cases were observed (REACH registration dossier (Accessed Oct. 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified" in the oral route. However, classification was not possible due to lack of data since there was not sufficient information available for classification in other routes. (1) It was reported that in an oral toxicity study of this substance (a mixture of isomers with a composition ratio of 7:1) with rats dosed by gavage (OECD TG422, GLP, for 42 days (males), for 41 to 46 days (females)), no effect was observed at 100 mg/kg/day (converted guidance value: 46.7 mg/kg/day (males), 45.6 mg/kg/day (females), within the range for Category 2); and effects on the liver, kidney and blood system were observed at or above 300 mg/kg/day (converted guidance value: 140 mg/kg/day (males), 137 mg/kg/day (females), in the range corresponding to "Not classified") (Toxicity Testing Results for Existing Chemical Substances under the Chemical Substances Control Law (2013)). (2) It was reported that in a 90-day oral toxicity study of this substance (a mixture of a cis isomer, ca. 10 to 12% and a trans isomer, ca. 88 to 90%) with rats dosed by feeding (OECD TG408, GLP), no effect was observed at 100 mg/kg/day (within the range for Category 2) (REACH registration dossier (Accessed Oct. 2020), EFSA (2016)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
It was classified in Category 2 from 48-hour EC50 = 8.25 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
It was classified in Category 3 because it was rapidly degradable (a 28-day degradation rate by BOD: 98% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 2009)) and due to 21-day NOEC = 0.79 mg/L for crustacea (Daphnia magna) (REACH registration dossier, 2021). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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