NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	25103-58-6
Chemical Name	tert-Dodecanethiol
Substance ID	m-nite-25103-58-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	There are flash points of 95 deg C (closed cup) and 82 deg C in SIDS Dossier (2014), and it was classified in Category 4 by adopting 82 deg C. Besides, because it is estimated that some of the isomer mixtures have a flash point above 93 deg C, such products should be classified as "Not classified" by checking each flash points of them.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 212 deg C (SIDS Dossier (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on 2 reports of LD50 values of 4,380 mg/kg and 6,800 mg/kg for rats (PATTY (6th, 2012)), this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the LD50 value of 12,600 mg/kg (PATTY (6th, 2012)) for rabbits, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Although there is a report that as the LC50 value for rats of > 12 mg/L (SIDS Dossier (2014)), it is evaluated as Reliability 4 (not assignable), therefore, the substance was not possible to classify by this value alone.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is reported that in a skin irritation test (OECD TG 404) using rabbits, as a result of a semi-occlusive application with an undiluted solution of this substance for 4 hours, it was irritating since well-defined or moderate erythema and slight to moderate erythema were observed (SIDS (2014)). Moreover, it is reported that in another irritation study using rabbits, irritation was observed after 4-hour application (PATTY (6th, 2012)). 　From the above, this substance was classified in Category 2. 　The information of IUCLID used in the previous classification could not be confirmed because it was not available. The classification was revised because of the updated information.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	In an opacity and permeability assay (OECD TG 437) using bovine corneas, the irritancy score was -0.5 plus or minus 0.6, and the substance was predicted to be a non-corrosive or non-severe eye irritant (SIDS (2014)). The result of this study was negative, however, considering the report of skin irritation observed in rabbits, this substance is considered as a potential eye irritant (SIDS (2014)). 　From the above, this substance was classified as "Classification not possible" due to insufficient information for judgment of eye irritation. 　The information of IUCLID used in the previous classification could not be confirmed because it is not available. The classification was revised along with updating of the information.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1B	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is reported that in Buehler tests (OECD TG 406) using guinea pigs, weak sensitization was observed (SIDS (2014)). Moreover, it is reported that in a Local Lymph Node Assay (OECD TG 429) using mice, from the EC3 of 31%, the substance is weakly sensitizing (SIDS (2014)). 　From the above results, in SIDS (2014), it is concluded that this substance is a weak sensitizer. 　Therefore, this substance was classified in Category 1B. 　Information from IUCLID used in the previous classification could not be confirmed because it was not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　There is no data on in vivo. 　As for in vitro, bacterial reverse mutation tests, a mouse lymphoma assay and a sister chromatid exchange test using cultured mammalian cells were negative, and a chromosomal aberration test had an equivocal result (SIDS (2014), PATTY (6th, 2012)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In an inhalation study using pregnant rats and mice during organogenesis (rat: Gestational Day 6-19, mouse: Gestational Day 6-16), no effects were observed by administration of the test substance in both maternal animals or fetuses (SIDS (2014), PATTY (6th, 2012)). 　However, there was no information on effects on fertility and sexual function, therefore, the classification was not possible.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	There is no single exposure data of this substance in humans. 　As for experimental animals, it is reported that in a single oral administration study using rats, moderate sedation, ataxia, mild tremors, and diuresis were observed at 6,830 mg/kg, which is above Category 2 (PATTY (6th, 2012)). Moreover, it is reported that in a single 4-hour inhalation study using rats, labored breathing, exophthalmos and signs of decreased consciousness were observed but no death cases were found (PATTY (6th, 2012)). 　Therefore, this substance was classified in Category 3 (narcotic effects). Based on the data of the new information source, the classification result was changed from the previous classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no information on humans. 　As for experimental animals, 28-day inhalation toxicity tests using rats, mice or dogs were conducted at two concentrations. Since the lower exposure concentration was a vapor and the higher exposure concentration was a saturated vapor, classification was conducted using the guidance value of vapor for the lower concentration and the guidance value of the mist for the higher concentration. In rats, increase in liver weights, mild renal tubular degeneration related to nephropathy inherent in male rats and so on were observed at not less than 26 ppm (0.22 mg/L) (converted guidance value: 0.07 mg/L), which is equivalent to Category 1 based on the guidance value of vapor (Environmental Risk Assessment for Chemical Substances vol.9 (Ministry of the Environment, 2011), SIDS (2014)). In mice, hepatocellular hypertrophy was observed at not less than 25 ppm (0.21 mg/L) (converted guidance value: 0.06 mg/L), which is equivalent to Category 1 based on the guidance value of vapor, and increase in ALT, an absence of, or decrease in, corpora lutea in the ovary and so on were observed at 109 ppm (0.90 mg/L) (converted guidance value: 0.28 mg/L), which is above Category 2 based on the guidance value of mist (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011), SIDS (2014)). In dogs, hepatocellular hypertrophy, increase in ALT, increase in alkaline phosphatase and so on were observed at 109 ppm (0.90 mg/L) (converted guidance value: 0.28 mg/L), which is above Category 2 based on the guidance value of mist (Environmental Risk Assessment for Chemical Substances vol.9 (Ministry of the Environment, 2011), SIDS (2014)). 　Of the above, since the nephrosis is inherent in male rats, it was not adopted as evidence for classification. 　In addition, although an effect on the liver was observed, no severe effect was observed at the doses equivalent to up to Category 2. Therefore, this substance was classified as "Classification not possible." 　Besides, in the previous classification, hepatocellular hypertrophy was used as the basis for classification, but it was not determined as a serious effect, therefore, the previous classification result was different from this time.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, from the numerical data (viscosity: 2.84 mPa*s (20 deg C), density: 0.856 g/cm 3 (20 deg C)) listed in GESTIS (Access on October 2016), the kinematic viscosity is calculated as 3.32 mm2/sec (20 deg C).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.075 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, it is classified in Category 1 because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: average 2 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2012)), and its 21-day NOEC = 0.0108 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999); SIDS, 2014). 　If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, it is classified in Category 1 because it is not rapidly degradable (Non-biodegradable, a degradation rate by BOD: average 2 % (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2012)), and its 96-hour LC50 = 0.38 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). 　It was classified in Category 1 from the above results.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information