Latest GHS Classification Results by the Japanese Government (edited by NITE)

Japanese



GENERAL INFORMATION
 
Item Information
CAS RN 25167-67-3
Chemical Name Butene (all isomers)
Substance ID m-nite-25167-67-3_v1
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) To Guidance List
UN GHS document (External link) To UN GHS document
FAQ(GHS classification results by the Japanese Government) To FAQ
List of Information Sources (Excel file) List of Information Sources
List of Definitions/Abbreviations Definitions/Abbreviations
Sample Label by MHLW (External link) MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) To OECD/eChemPortal (External link)

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Explosives Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Flammable gases Category 1


Danger
H220 P210
P377
P381
P403
 It is classified in class 2.1 in UNRTDG (UN1012) (a lower explosion limit 1.6 to 1.8, an upper limit 9 to 10 % (ACGIH (7th, 2008))). FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Aerosols Not classified (Not applicable)
-
-
- -  Not an aerosol product. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Oxidizing gases Not classified
-
-
- -  It is classified in class 2.1 in UNRTDG (UN1012) and flammable gases. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Gases under pressure Liquefied gas


Warning
H280 P410+P403  From critical temperatures (146.5 degrees C (1-butene), 155.5 degrees C (trans-2-butene), 162.4 degrees C (cis-2-butene), 144.7 degrees C (isobutene)) (GESTIS (Access on June 2015)) above 65 degrees C, it was classified in liquefied gas (low pressure liquefied gas). FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Flammable liquids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Flammable solids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Self-reactive substances and mixtures Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Pyrophoric liquids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Pyrophoric solids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Self-heating substances and mixtures Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13 Oxidizing liquids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14 Oxidizing solids Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15 Organic peroxides Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16 Corrosive to metals Classification not possible
-
-
- -  No established test method suitable for gaseous substances. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17 Desensitized explosives -
-
-
- - - - -

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
1 Acute toxicity (Oral) Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Dermal) Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Gases) Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 The category cannot be determined from a reported LC50 value (4 hours) > 10,000 ppm for rats for a mixture consisting of trans-2-butene (55.3 vol%), cis-2-butene (42.4 vol%), and others (n-butane, 1-butene, and so on) (2.3 vol%) (SIDS (2012)).
 Besides, an LC50 value (4 hours) 270,000 ppm for rats of isobutene is reported (SIDS (2012)).
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Vapours) Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1 Acute toxicity (Inhalation: Dusts and mists) Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2 Skin corrosion/irritation Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 Besides, it is reported in SIDS (2012) that a liquefied product of 2-butene could cause frostbite in direct contact with skin.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3 Serious eye damage/eye irritation Classification not possible
-
-
- -  The classification is not possible due to lack of data.
 Besides, it is written that 1-butene is mildly irritating to eyes (HSDB (Access on June 2015)).
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Respiratory sensitization Classification not possible
-
-
- -  Due to lack of data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4 Skin sensitization Classification not possible
-
-
- -  Due to lack of data, the classification is not possible. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5 Germ cell mutagenicity Classification not possible
-
-
- -  The classification is not possible due to lack of data. There is no in vivo information on a mixture of butene isomers.
 As for in vivo data on isomers, it is reported a micronucleus test using mice on 1-butene was negative (SIDS (2012), ACGIH (7th, 2001)). As for isobutene, it is reported a DNA adduct formation test using rats and mice was negative and a micronucleus test using mouse bone marrow cells was negative (SIDS (2012), ACGIH (7th, 2001)).
 As for in vitro, it is reported a bacterial reverse mutation test was negative (NTP DB (Access on June 2015)).
 As in vitro data on isomers, it is reported that a bacterial reverse mutation test on 1-butene was negative (SIDS (2012), ACGIH (7th, 2001)), a bacterial reverse mutation test and in vitro mammalian cell chromosomal aberration test on 2-butene were negative (SIDS (2012), ACGIH (7th, 2001)), and a bacterial reverse mutation test , a mouse lymphoma test, a transformation test using mouse embryo fibroblast cells, and a micronucleus test using human lymphocytes on isobutene were negative (SIDS (2012), ACGIH (7th, 2001)).
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6 Carcinogenicity Classification not possible
-
-
- -  There is no human carcinogenicity information on a mixture of butene isomers.
 As for experimental animals, a carcinogenicity test using rats and mice with 2-year inhalation exposure was conducted only on isobutene which is one of the isomers, and in male rats, follicular cell carcinomas in the thyroid were observed in 5/50 animals of the highest concentration 8,000 ppm group (SIDS (2012), ACGIH (7th, 2008)). However, because the evidence of carcinogenicity, including the thyroid, was not shown in female rats nor male or female mice, and the relevance of thyroid tumor formation in for humans is unclear (SIDS (2012), ACGIH (7th, 2008)), ACGIH classified the carcinogenicity of isobutene in A4 (ACGIH (7th, 2008)). Because isobutene is classified in A4 by ACGIH and no information on the other isomers is not available, a mixture of butene isomers was classified as "Classification not possible."
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7 Reproductive toxicity Classification not possible
-
-
- -  No reproductive toxicity data on a mixture of butene isomers.
 As for data on isomers, rats were in inhalation exposure to 1-butene (purity not less than 99%) or 2-butene (a mixture of cis- and trans-isomers, purity not less than 95%) two weeks before mating, through mating and gestation periods in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422). No effects on sexual organs and fertility of parent animals and no effects on survival rate and growth until four days after the birth of the offspring are observed (SIDS (2012), ACGIH (7th, 2008)).
 Besides, in a teratogenicity test in which pregnant rats were in inhalation exposure to isobutene on day 5 to 21 of gestation, maternal toxicity, fetal toxicity, or teratogenicity were not observed (SIDS (2012), ACGIH (7th, 2008)).
 From the above, in the tests on an individual isomer neither reproductive nor developmental toxicity were found. However, the reproductive toxicity tests other than the teratogenicity test on isobutene were screening tests and it is considered that there is no data set which completely deny the effects on reproductive/developmental toxicity of each isomer. Therefore, the substance was classified as "Classification not possible" due to lack of data.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- -  As for experimental animals (rats, mice), it is reported that the inhalation exposure to isobutene, 1-butene, cis-2-butene, or trans-2-butene (17.2 to 22.7%) caused narcotic action within 10 minutes and that asphyxia was caused after the inhalation exposure to 1-butene, cis-2-butene, or trans-2-butene of 21-27% (210,000-270,000 ppm), isobutene of 32% (320,000 ppm) (ACGIH (7th, 2008), SIDS (2012), PATTY (6th, 2012)).
 As for humans, it is reported that the inhalation of isobutene could cause narcotic action or asphyxia by reducing the available concentration of oxygen (SIDS (2012)).
 Because the asphyxia and narcosis mentioned above were due to lack of oxygen in a limited space, the substance was classified as "Classification not possible." Besides, there is no information on a mixture of butenes.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- -  No repeated dose toxicity information on a mixture of butene isomers.
 As for experimental animals, toxicity information in an inhalation route was obtained on 1-butene, 2-butene, and isobutene that are the isomers, and toxicity information in an oral route was obtained on isobutene.
 Regarding an inhalation route, toxicity effects were not observed on 1-butene and 2-butene up to doses of 5,000 ppm or 8,000 ppm in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test using rats by an inhalation route (SIDS (2012)). The doses correspond to a dose above Category 2. However, because these tests are screening tests and there is not sufficient information, the classification is not possible.
 Regarding isobutene, in a 14-week inhalation toxicity test using rats, minimal hypertrophy of goblet cells in the nasopharyngeal duct in the nasal cavity was observed from the lowest concentration of 500 ppm. In a 105-week inhalation toxicity test using rats, increased hyaline degeneration of the olfactory epithelium in the nasal cavity was observed from the lowest concentration of 500 ppm. With mice, no effect was observed in a 14-week inhalation toxicity test and in a 105-week inhalation toxicity test, increased hyaline degeneration of the respiratory epithelium in the nasal cavity were observed from the lowest concentration of 500 ppm and increased hyaline degeneration of the olfactory epithelium from 2,000 ppm (NTP TR487 (1998)).
 However, SIDS remarked that these effects on mucous membrane in the nasal cavity were non-specific and adaptive changes to an irritant and not significant toxic effects and that the NOAEL was 8,000 ppm (a converted value based on an exposure condition: 6,222 ppm) in a 14-week inhalation toxicity test using rats, 2,000 ppm in a 105-week inhalation toxicity test using rats, 8,000 ppm (a converted value based on an exposure condition: 6,222 ppm) in a 14-week inhalation toxicity test using mice, and 8,000 ppm in a 105-week inhalation toxicity test using mice (SIDS (2012)).
 Therefore, it corresponds to "Not classified."
 Besides, isobutene was dissolved in olive oil in a freezer to make a solution which was used in a 28-day gavage administration toxicity test using rats. Although no effects were observed up to the highest dose of 150 mg/kg/day (a converted value from dosing days: 46.7 mg/kg/day), the classification is not possible due to being within a range of Category 2 (SIDS (2012)).
 Because a mixture of butene isomers is gas and an inhalation route is considered to be the principal exposure route, it is estimated to be "Not classified."
 But it was classified as "Classification not possible" due to lack of data.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10 Aspiration hazard Not classified (Not applicable)
-
-
- -  "Gases" according to GHS definition. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification Classification year (FY) GHS Classification Guidance for the Japanese Government
11 Hazardous to the aquatic environment Short term (Acute) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
 Besides, 96-hour EC50 = 12 to 15 mg/L for algae, 48-hour EC50 = 19 to 23 mg/L for crustacea, and 96-hour LC50 = 18 to 21 mg/L for fish as QSAR estimation (all SIDS, 2012) are reported in SIDS, but they were not used for the classification.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11 Hazardous to the aquatic environment Long term (Chronic) Classification not possible
-
-
- -  The classification is not possible because appropriate data are not obtained.
 Besides, a 96-hour chronic value = 1.6 to 1.8 mg/L for algae, a 16-day chronic value = 1.2 to 1.4 mg/L for crustacea, and a 30-day chronic value = 2.4 to 2.9 mg/L for fish as QSAR estimation (all SIDS, 2012) are reported in SIDS, but they were not used for the classification.
FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12 Hazardous to the ozone layer Classification not possible
-
-
- -  No data. FY2015 GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
  • An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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