NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	25167-80-0
Chemical Name	chlorophenol
Substance ID	m-nite-25167-80-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)
Sample SDS by MHLW (External link)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule (o-, m-, p-).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Not Gas (GHS definition) (o-, m-, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products (o, m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Not Gas (GHS definition) (o, m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Not Gas (GHS definition) (o, m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Category 4 because of its flash point: 64degC (closed cup) (o-). Solid (GHS definition) (m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	Liquid (GHS definition) (o-) No data available (m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive or self-reactive properties present (o-, m-, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data. (o-body) It is a solid by the definition of GHS. (m-body, p-body)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	It is a liquid according to the definition of GHS. (o-body) It was judged that it did not ignite spontaneously from the fact that the measurement of flash point was performed at the temperature of 112 degC or more (ICSC (1999)). (m-body, p-body)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	The test suitable for a liquid state substance is not established. (o-body) The test suitable for a solids material is not established. (Solid with a melting point of 140 degC or less) (m-body, p-body)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)(o, m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen and chlorine (but not fluorine) and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements) (ortho). Solid (GHS definition) (meta, para).	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen and chlorine (but not fluorine) and the oxygen and chlorine are chemically bonded only to carbon and hydrogen (but not to other elements) (meta, para). Liquid (GHS definition) (ortho).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure (o-, m-, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available (o, m, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	O-object: lower LD50= 670mg/kg was adopted between two data (the Health, Labor and Welfare Ministry reports (2005), EHC 93 (1989)) of rat LD50 values, and it was set as Category 4. M-object: It was set as Category 4 based on rat LD50= 570mg/kg (EHC 93 (1989)). P-object: It was set as Category 3 based on rat LD50= 261mg/kg (EHC 93 (1989)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	O-body: It was set as Category 4 based on rabbit LD50 = 1000 - 1580mg/kg (ATSDR (1999)). M-body: no data. P-body: no data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	o-body is liquid, m-body and p-body are solids, respectively according to the definition of GHS.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	o-body: saturated vapor pressure concentration is 2277ppm (11.98mg/L). And it was classified as Category 2 based on rat LC50 = 389.5ppm (converted from 2.05mg/L) (ATSDR (1999)) obtained from the test considered to have been performed with vapor. m-body: No data. p-body: No data.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on mouse LC50=49 mg/L (DFGOT vol.1 (1991)) of the inhalation test carried out in mist, it carried out the outside of Category. O-body: datum without. M-body: datum without. P-body: saturated vapor pressure pressures concentrations is 128.7ppm (0.677mg/L), and it was set to category 4 based on rat LC50 = 1.01mg/L (IUCLID (2000)) obtained by the test considered that the dust performed.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	o-body: It was classified as Category 1A-1C based on the statements that serious stimulativeness and corrosion were observed on rabbits (ATSDR (1999)) and that there were redness and pain on humans (ICSC (J) (1999)). m-body: It was classified as Category 2 based on the statement that there are redness and pain on humans (ICSC (J) (1999)). p-body: It was classified as Category 1A-1C based on the statements that there were serious stimulativeness and corrosiveness for animals (ATSDR (1999), RTECS (2004), and IUCLID (2000)) and that there are redness and pain on humans (ICSC (J) (1999)). In addition, monochlorophenol is reported to have corrosivity on animals (ATSDR (1999)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	O-body : it is a skin corrosive substance, and there is a statement that significant discomfort and corrosion were seen with the rabbit (ATSDR (1999)), and that redness, a pain, and a haze eyes were seen with humans (ICSC (J), (1999)). So it was set as Category 1. M-body: It was set as Category 2A-2B based on the statement that redness, a pain, and a haze eyes were seen with humans (ICSC (J) (1999)) . P-body: it is a skin corrosive substance, and there is a statement that caustic was seen with the rabbit (RTECS and (2004), IUCLID (2000)), and that redness, a pain, and a haze eyes were seen with human (ICSC (J) (1999)). So it was set as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	o-object: no data, m-object: no data, p-object: no data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	o-object: no data, m-object: no data, p-object: no data	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	O-body : There was no positive finding in any of human over generation epidemiology, over generation mutagenicity test, in vivo mutagenicity test of the productive cells and the somatic cells, and based on the statement (ATSDR (1999)) that it gave negative in the in vivo sister chromatid exchange tests using the mouse spermary cells and marrow cells, and on the statement (IUCLID (2000)) that it gave negative for the in vivo mouse micronucleus assay. So we classified it as Out Of Category according to the technical guideline. m-body: No data. p-body: Based on the fact that there being no in vivo test results and there being no strong positive in vitro examination results in multiple indices So we presupposed that we could not categorize it according to the technical guideline.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	O-body: It was set as Category 2 based on what is classified into 2B in Japan Society for Occupational Health (JETOC specially data No.190 (2004)). M-body: datum without. P-body: datum without.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	O-object: Since with the rat and the mouse, although there was no descriptions of general toxicity on parental animals, there was the description of decrease of litters count and increase conception rate and stillborn pups count (IRIS (2005) and EHC 93 (1989)), it was classified into Category 2. M-object: no data. P-object : Since with rats and mice, although there is no descriptions of general toxicity on parental animals, there was description of effects on spermatogenesis (genetic factor, spermatozoa morphology, sperm motility and sperm count), increase postimplantation lethality, embryotoxicity, fetotoxicity and fetal death (RTECS (2004)), it is classified into the Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	O-body: In the dose of guidance value within the Category 1, in rats and mouse, there are backward curvature, a woolen handstand, excitement, a respiratory promotion action, the signs of an eye stimulus, the excess of saliva, thrill and convulsion (ATSDR (1999), RTECS (2004), IUCLID (2000)), and in humans, there are lethargica, a sense of weakness and convulsion (ICSC (J) (1999)). It is classified into Category 1 (central nervous systems) based on these. And there are stimulation of the nasal mucosa is indicated by the rat (IUCLID (2000)), and a cough, breathlessness, and pharyngalgia are indicated in humans (ICSC (J) (1999)). It is classified into Category 3 (respiratory irritation) based on those. M-body: datum without. P-body: By the dose of guidance value within the Category 1, in a rat, there are the description that there are a droopy eyelid, blood vessel extension, polypnea, dyspnoea, the low response to a sound stimulus, clonic convulsion, and decubitus position (IUCLID (2000)), and in human, there are dizziness, headache, closeness, feeling of sickness, vomiting, a weakness, and unconsciousness (ICSC (J) (1999), IUCLID (2000)). So it is classified into Category 1 (central nervous systems). And there is the statement (ICSC (J), (1999), IUCLID (2000)) that a cough, pharyngeal pain, and mucosa stimulativeness are seen by humans. It is classified into Category 3 (respiratory irritation).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (central nervous system, liver)	Warning	H373	P260 P314 P501	O-object : It was classified to as Category 2 (central nervous systems,liver) based on the statement that in rats and mouse, with administration of guidance value within the limits of Category 2, tremorg, reduction of operant behavior, hypersalivation, hyperkinesia, reduction of brain weight, the increase in liver weight, hepatocellular hypertrophy, and hepatocytes are observed (the Health, Labor and Welfare Ministry reports (2005), ATSDR (1999)) . M-object: no data. P-object: It was classified to as Category 2 (central nervous systems) based on the statement that sleep disorders (sleepiness or insomnia), excitability, mood disorders, and a rapid fatiguability were observed in humans (IUCLID (2000)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available (o-, m-, p-)	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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