NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2524-03-0
Chemical Name	O,O-Dimethylchlorothiophosphonate
Substance ID	m-nite-2524-03-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified	- -	-	-	Flash point is >105 degC (Lange (16th, 2005)) is >93 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	The substance is estimated not to fall into upper Division 4.2 (Substances liable to spontaneous combustion), PG I since it is classified into Class 6.1, PG II in UNRTDG (UN2267).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Classified into Not classified since the substance is not combustible gas though information is available that it gradually reacts with water forming hydrogen chloride having corrosive properties (IMDG (2006)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance contains oxygen and chlorine which are chemically bonded to atoms except carbon.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	LD50 values of 664 mg/kg, 1260 mg/kg, 500 - 100 mg/kg, 1605 mg/kg, 360 mg/kg and 500 - 2000 mg/kg for rats (IUCLID (2000)) correspond to Category 4.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	A LD50 value of 590 mg/kg for rats (IUCLID (2000)) corresponds to Category 3 and LD50 values >2150 mg/kg, >1500 mg/kg and >1000 mg/kg for rabbits (IUCLID (2000)) correspond to Category 4 or "Not classified". The category for rats with higher hazard was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	LC50 values (4-hour) of 0.34 mg/L (51.8 ppm) and 0.48 mg/L (73.1 mg/L) for rats (IUCLID (2000)) correspond to Category 1. Since the LC50 values were lower than 90% of saturated vapour pressure concentration (4.32 mg/L), the classification criteria for gas was adopted.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Since "highly irritating" after 4-hour application and "corrosive" after 24-hour application were reported in a rabbit Draize test (IUCLID (2000)), the substance was classified into Category 2 based on the result after a 4-hour application.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on results of "corrosive" or "highly irritating" in rabbit tests (IUCLID (2000)) and a report of "strong irritant to eyes" as human health effects (HSDB (2003)), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a positive result in a rat dominant lethal test (in vivo heritable germ cell mutagenicity tests) using the formulation (HSDB (2003)), evaluation of this substance itself is difficult and a negative result was reported in a mouse micronucleus test (in vivo somatic cell mutagenicity tests) (HSDB (2003)). Therefore, classification was not possible. As relevant information, from in vitro mutagenicity tests, there are reports of a negative result in an Ames test and positive results in chromosomal aberration test using Chinese hamster ovary cells, gene mutation test using mouse lymphoma cells and morphological transformation test using mouse BALB/3T3 cells (HSDB (2003)). In addition, the substance is an existing chemical substance, for which mutagenicity was established under the provisions of Article 57-3 of the Industrial Safety and Health Law.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although there is a report that slightly increased preimplantation losses or early resorptions were observed at maternal toxicity doses in a rat developmental toxicity test by inhalation during organogenesis period (IUCLID (2000)), no changes in the same reproductive parameters were noted at higher doses in a previous dose finding test (IUCLID (2000)). Since the statistical significance of the slight increases was not indicated, classification was not possible.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In mice treated by ip injection, abnormal gait and hypersensitivity were observed at 200 mg/kg and ataxia, tremors, cyanosis, paralysis and ptosis were observed at 300 mg/kg (HSDB (2003)). In a rabbit dermal test, depressed activity was noted at 316 mg/kg within the guidance value range for Category 1 (RETCS (2006)). Additionally, the acute effects include miosis, blurred vision, headache, dizziness, muscle twitching, marked muscle weakness and vomiting, diarrhea, abdominal pain, convulsion and coma. Oral and dermal exposure can cause decreased heart rate (SITTIG (5th, 2008)). Additionally, exposure can cause severe organophosphate poisoning with headache, dizziness, blurred vision, tightness in the chest, sweating, nausea and vomiting, diarrhea, muscle twitching, convulsions and coma (HSFS (2001)). Since these information are obtained from ip injection test or documents in List 3, classification would be not possible according to the guidance. However, the substance is an organophosphate and signs associated with effects on nervous system were reported in documents in List 3, therefore, the substance was classified into Category 2 (nervous system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs)	Warning	H373	P260 P314 P501	There is a report that a respiratory distress syndrome and increased lung and trachea weights were observed at 0.030 mg/L in a rat 13-week inhalation test (GLP) (IUCLID (2000)). Although the substance correspond to Category 1 based on guidance value range, the substance was classified into Category 2 (respiratory system) because of information in List 2 and non-meeting Decision criteria 1b 3).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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