NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	25550-58-7
Chemical Name	dinitrophenol
Substance ID	m-nite-25550-58-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Division 1.1	Danger	H201	P370+P372+P380+P373 P210 P230 P234 P240 P250 P280 P401 P501	Division 1.1, UNRTDG No. 0076, Class: 1.1D(6.1) (classified in each topic of the physical chemical hazard with drier products UN No. 0076, though the substance has UN No. 0076, 1320, and 1599; difference of the moisture content)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified	- -	-	-	Not classified because of UNRTDG No. 0076, Class: 1.1D(6.1) (not Class: 4.1) though "Flammable" (Sax, 11th, 2004)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Classified in explosives	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Not classified because of UNRTDG No. 0076, Class: 1.1D(6.1) (not Class: 4.2)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not classified because of UNRTDG No. 0076 Class: 1.1D(6.1) (not Class: 4.2)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified	- -	-	-	Not classified because of UNRTDG No. 0076 Class: 1.1D(6.1) (not Class: 5.1).	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	Since there was a description that 3 - 46mg/kg (ATSDR, 1995), 1 - 3g (17 - 50mg/kg assuming that the weight is 60kg)(HSDB, 2003) as oral lethal dose for human, it was classified as category 2. In addition, although the data of LD50 value of animal was not found, there is an observation of LDLo=30mg/kg (RTECS, 2006) of a rat. [Note] There were six isomers in dinitrophenol. But about the hazardous property over the health of this ID, investigations and classifications were done as CAS No.25550-58-7 (isomer mixture). Also refer to the classification result of 2, 4-dinitro phenol (ID No.0419, CAS No.51-28-5).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Data without. In addition, HSDB (2003) has a statement that the inhalation toxicity of dust is high, and ATSDR (1995) has the death report of humans in 40mg/m3 (there is possibility of chronic exposure).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	There is a statement that the human skin is stimulated (HSFS(2003)). But the data which is supported is not found. And since data is insufficient, it cannot be classified. In addition, the GHS classifications of 2,4-dinitro phenol (ID No.0419, CAS No.51-28-5) is set as category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	There is the description that it irritates to human eye in HSFS (2003). But the supporting evidence data is not found, and data is insufficient. Therefore, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Although there is a statement which suggests human skin sensitization to PATTY (5th, 2001), HSDB (2003), and HSFS (2003), since data is insufficient, it cannot classify.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The data as isomer mixture is not found, and it cannot classify. In addition, there is a positive report by the somatic cell in vivo mutagenicity test (chromosome aberration test of mouse bone marrow cells) of 2,4-dinitrophenol in ATSDR (1995), and by the Ames test of 2,3-;2,5-; 3,4-dinitrophenol.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although there is the description which suggests the effect on the fetus of human in SITTIG (4th, 2002), since data is insufficient, it cannot be classified. In addition, for 2,4-dinitro phenol, there is a report that incidences of still birth rate increased in rat in ATSDR (1995) .	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (systemic, nervous system, blood system, eye), Category 2 (kidney, liver), Category 3 (respiratory tract irritation)	Danger Warning	H370 H371 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	The substance was classified as Category 1 (systemic toxicity, nervous system, blood system, eyes). Based on the reports in ATSDR (1995), a Priority 1 document, of systemic toxicity (increase of oxygen consumption due to accelerated metabolism at cellular level, increases in respiratory and pulse, and rise in body temperature) and effects on the nervous system, blood system (decrease of leukocyte) and eyes (cataract) in humans (and there are similar reports in PATTY (5th, 2001), HSDB (2003), HSFS (2003) respectively). The substance was also classified as Category 2 (kidneys, liver) and 3 (airway irritant) based on the reports in the Priority 2 documents, HSDB (2003) and HSFS (2003), of effects on the liver and kidneys and airway irritation.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (systemic, nervous system, blood system, eye, kidney, liver)	Danger	H372	P260 P264 P270 P314 P501	We classified it into Category 1 (systemic toxicity, nervous systems, blood systems, the eye, kidney, liver) based on the description about the systemic toxicity (it is based on the oxygen-consumption increase by the hypermetabolism on the cell level, respiration and pulsation increase, and hyperthermic) and effects on the nervous systems, blood systems (reduction in white corpuscles) and the eyes (cataract) (ATSDR (1995; Priority 1 document)), and the description about the effects of four isomers (2, 3-; 2, 5-; 3, 4- ;3, 5- dinitro phenol) on the kidney and liver in humans (PATTY (5th, 2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Insufficient data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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