NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	26087-47-8
Chemical Name	S-benzyl O,O-diisopropyl phosphorothioate [Iprobenfos]
Substance ID	m-nite-26087-47-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	Because it is stable to heat up to 150 deg C (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)), it is estimated that it does not ignite in contact with air at normal temperatures.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metalloid (P), but it is estimated that it does not react vigorously with water due to the water solubility result of 0.54 g/L measured (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	On the basis of 4 reported LD50 values for rats of 640 mg/kg (male), 600 mg/kg (female), 790 mg/kg (male), 680 mg/kg (female) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)), it was classified in Category 4.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	On the basis of a reported LD50 value for rats of > 4,000 mg/kg (male, female) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)), it was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	There were 4 reported LC50 values (4 hours) for rats of > 5.15 mg/L (male), > 5.15 mg/L (female), 0.34 mg/L (female), 1.12 mg/L (male) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). The former 2 data are from the test carried out in 2006, and the latter 2 data are from the one done in 1986. Each test was performed by GLP, the test in 2006 was done by nose-only exposure using animals 8 weeks of age, and the test in 1986 was done by whole body exposure using animals 6 -8 weeks of age. In OECD TG403, nose-only exposure is recommended, and animal age is specified as 8-12 weeks. Therefore, by adopting > 5.15 mg/L (male), > 5.15 mg/L (female) from the test which is a later one and which test methods were appropriate, the substance was classified as "Not classified." 　In addition, the reference value of mist was applied because LC50 values are higher than the saturated vapor pressure concentration (0.0014 mg/L). On the basis of newly obtained information, the category was revised.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	Because in a skin irritation test using rabbits, no irritation was observed, and this substance was evaluated as not a skin irritant (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)), it was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Because it is reported that in an eye irritation test using rabbits, slight irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)), it was classified in Category 2B.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Because in a skin sensitization test using guinea pigs (maximization test), medium sensitization was observed (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a micronucleus test using bone marrow cells of mice was negative, and as for in vitro, bacterial reverse mutation tests were negative, and mammalian cell chromosome aberration tests were positive (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Not classified	- -	-	-	In carcinogenicity tests in rats or mice dosed by feeding for two years, carcinogenicity was not observed (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). It was classified as "Not classified" because it was negative in carcinogenicity in 2 species of experimental animals.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Among 2-generation reproductive toxicity tests using rats by oral route (diet administration), in one test, abnormality in offspring was not observed at the dose (300 ppm) at which inhibition of red blood cell cholinesterase activity was found in F0, F1 parent animals, in the other test, at the dose (1,500 ppm) at which reduced weight gain, feed intake reduction, and increased relative liver weight, etc. were found in F0, F1 parent animals, reduced weight gain observed in F1, F2 pups, in addition delayed sexual maturation (delayed preputial separation, delayed vaginal opening) in F1 offspring were found (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). In development toxicity tests using pregnant rats and pregnant rabbits by gavage administration (rats: 7 – 19 days of pregnancy, rabbits: 6 – 18 days of pregnancy), in rats, abnormality was not found in fetuses at the dose (100 mg/kg/day) at which maternal animal toxicity (salivation, increased absolute/relative liver weight) was observed, but in rabbits, increased post-implantation embryonic mortality was found at the dose (80 mg/kg/day) at which maternal animal toxicity (reduced weight gain, feed intake reduction) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). 　As above, it was classified in Category 2 for this hazard class because in a 2-generation reproductive toxicity test in rats, growth/development suppression was observed in next generation at the dose at which toxic effects occurred in parent animals, and in the developmental toxicity test in rabbits, increased post-implantation embryonic mortality was observed at the dose at which maternal animal toxicity occurred. Besides, the classification was changed because it was based on new information source that was available after the previous classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There is no data on single exposure in humans. In experimental animals, it is described that in a single oral dose study using rats and mice on this substance, bradykinesia, prone position, tachypnea, straub tail, convulsions, eyelid closure with lacrimation, and piloerection were observed but resolved at four days (rats) or three days (mice) after administration (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). Although minimal doses at which these symptoms appeared were not described, it is written that test doses were 360-1,548 mg/kg in rats and 592-4,827 mg/kg in mice, and a minimal lethal dose was 518 mg/kg in rats and 769 mg in mice (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). Therefore, it is thought that the doses where effects were seen are close to the minimal lethal dose which is within the range of Category 2. As for inhalation route, it is described that in a single 4-hour inhalation exposure study in rats, respiratory depression, sleep/coma, inanimation, piloerection, behavioral inhibition, back arch position, rough fur, crouching position, tremor, weakening, and gasping were observed, but survived animals recovered 13 days after exposure (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). Although minimal doses at which these symptoms appeared were not described, it is written that test doses were 0.25-1.48 mg/L and a minimal lethal dose was 0.80 mg/kg in males and 0.51 mg/kg in females (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). Therefore, it is thought that the doses where effects were seen are close to the minimal lethal dose which is within the range of Category 1. This substance is organophosphorus germicide, and organophosphorus pesticide (germicide) is generally known to cause effects on the nervous system in humans (IPCS, PIM G001 (1989)). From the above, it was classified in Category 1 (nervous system). The category was changed from the previous classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (nervous system)	Warning	H373	P260 P314 P501	There is no information in humans. 　In experimental animals, in a 90-day repeated dose neurotoxicity test using rats dosed by feeding, increase or increase tendency in startle reflex and decrease in total momentum and walk momentum were observed at 1,000 ppm (male: 70 mg/kg/day, female: 80 mg/kg/day) corresponding to Category 2, and in a 2-year repeated dose toxicity/carcinogenicity test using rats dosed by feeding, inhibition of red blood cell and brain cholinesterase activity (20% or more), etc. were observed at 1,000 ppm (male: 36.8 mg/kg/day, female: 45.5 mg/kg/day) corresponding to Category 2 (Risk Assessment Report (Pesticides) (Food Safety Commission, 2009)). 　Therefore, it was classified in Category 2 (nervous system).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.859 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 21-day NOEC (reproduction) = 0.1 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). 　If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and 96-hour LC50 = 3.36 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1997), Environmental Risk Assessment for Chemical Substances vol. 2 (Ministry of the Environment, 2003)). 　It was classified in Category 1 by drawing a comparison between the above results.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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