NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2634-33-5
Chemical Name	1,2-Benzothiazolin-3-one
Substance ID	m-nite-2634-33-5_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	An organic compound that contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	All of 3 LD50 values for rats (900 to 1200 mg/kg, 670 mg/kg (males), and 784 mg/kg (females)) (DFGMAK-Doc. 2 (1991)) correspond to Category 4.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" from an LD value of > 2000 mg/kg bw due to no deaths in the administration of 2000 mg/kg to rats (DFGMAK-Doc. 2 (1991)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	In a skin irritation test in which 0.1 mL of preparation including 73.1% of this substance was applied to rabbits for 4 hours or 1 hour, it was assessed as an irritant in a 4-hour application. (DFGMAK-Doc. 2 (1991)). On the other hand, in an occlusive test applied a solution of 500 to 1000 ppm in propylene glycol to 10 human volunteers for 24 hours, mild and visible redness of the skin shown in four persons and three persons reversed in 6 persons after 72 hours. Furthermore, the second application after 1 to 2 weeks reported that eight persons showed slightly severe dermal reactions (erythema and papules). (DFGMAK-Doc. 2 (1991)) From the above test results on animals and humans, it was classified in Category 2. Besides, it is classified in R38 in EU classification.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	From a strong irritant evaluated by application of a concentration of 12.5% to rabbits (DFGMAK-Doc. 2 (1991)) and R41 classified in EU Classification (EC-JRC (ESIS) (Access on July 2011)), it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Category 1A	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	This substance was classified as sensitizing from positive responses shown in 5 out of 15 persons (33%) in the last challenge test in a skin sensitization test using human volunteers. (DFGMAK-Doc. 2 (1991)) Also, there are many reports of occupational exposure observed positive responses as a result of skin application tests in workers having a skin disease such as dermatitis. (DFGMAK-Doc. 2 (1991)) It is reported that this substance has allergic effects to animals from a positive rate of 22% to 40% shown in a maximization test in guinea pigs. (DFGMAK-Doc. 2 (1991)). Furthermore, it is listed as a sensitizing substance in Contact Dermatitis. (Frosch) (Contact Dermatitis (4th, 2006), corresponding to List 1) From the above knowledge in which especially the positive responses of skin patch tests in humans with occupational exposure were frequently reported, it was classified in Category 1A.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Not classified	- -	-	-	From a negative result in a micronucleus test after oral administration in mice (in vivo mutagenicity test) (DFGMAK-Doc. 2 (1991)), it was classified as "Not classified." Besides, as in vitro tests, both an Ames test and a mouse lymphoma test reported negative results. (DFGMAK-Doc. 2 (1991))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	Lack of data. Besides, it is reported that a 2-year diet administration test at one concentration (0.1%) in 20 each of male and female rats did not show an increase in the tumor frequency compared to that in a control group without dosing. (DFGMAK-Doc. 2 (1991))	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" due to unknown details on adverse fetal effects and no indicated specific data on effects on sexual function and fertility in a two-generation test using rats in which parent toxicity at 500 ppm and adverse effects on fetal development and survival at 1000 ppm were reported. (EPA RED (2005)) Besides, an oral administration test in pregnant rats during an organogenetic period reported that neither fetal toxicity nor teratogenicity was observed except decreased fetal body weights and slightly delayed ossification at the dose where general maternal toxicity such as abnormal respiratory noise, reduced weight gain, and reduced food consumption was shown. (DFGMAK-Doc. 2 (1991)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	Neurotoxicity was observed in an acute oral toxicity test such as piloerection and upward curvature of the spine at 300 mg/kg or higher, and decreased activity, prostration, a decrease in abdominal muscle tonus, reduced righting reflex, and decreased breathing rate at 900 mg/kg. Because the doses based on the description correspond to Category 2 in Guidance values, it was classified in Category 2 (nervous system).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 90-day diet administration test in rats (0.002 to 0.1%), neither hematological and biochemical changes were observed nor remarkable pathological signs were reported except reduced weights of liver and pituitary in the high-concentration group (0.1%).(DFGMAK-Doc. 2 (1991)) Furthermore, in a 90-day diet administration test in dogs (55 to 495 mg/kg/day), reduced food consumption, reduced weight gain, and mild anemia were shown, but other adverse effects were not observed, and NOEL of 165 mg/kg/day was reported. (DFGMAK-Doc. 2 (1991)) From the above results, it corresponds to "Not classified" in an oral route, but effects in other routes are unknown due to no data. Therefore, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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