NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2691-41-0
Chemical Name	Cyclotetramethylenetetranitramine
Substance ID	m-nite-2691-41-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Unstable Explosive	Danger	H200	P370+P372+P380+P373 P201 P250 P280 P401 P501	Since the substance, which is wetted with less than 15% water by mass, is prohibited from being transported (Ship Safety Act / Article 5-1(v) of Public Notice of the Ministry of Transport, No.549 of 1979), we determined that it is an unstable explosive. (If the substance is wetted with not less than 15% water by mass, it is defined as UN0226 and Division 1.1. In addition, the desensitized substance is identified as UN0484 and Division 1.1.)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Pyrophoric solids	Not classified	- -	-	-	Given that its autoignition point is 234degC (ICSC (J) 2005), we determined that the substance does not ignite spontaneously in contact with air at room temperature and classified it into the "Not classified" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no bivalent -O-O- structure in the molecule	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	The rat LD50 values reported are 5500 mg/kg (males), 6400 mg/kg (females) (IRIS (accessed in August 2007), ATSDR (1997)), and 2300 mg/kg (PATTY (5th, 2005)). Based on the lowest LD50 value, the substance was classified into Category 5.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P361+P364 P280 P312 P321 P405 P501	No rat LD50 has been acquired, but a rat LD0 of 4239 mg/kg is reported (ATSDR (1997)) and so is a rabbit LD50 of 634 mg/kg (ARSDR 1997). Comparing these two values, the rabbit LD50, which is lower value of two, was selected as the basis for the classification of the substance into Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
2	Skin corrosion/irritation	Category 3	- Warning	-	-	Mild irritation of the skin was noted in rabbits after a dermal exposure to 109 mg/kg of the substance (ATSDR (1997)). Similarly, mild irritation of the skin was seen in rabbits after a dermal application of 500 mg of this substance (RTECS (accessed in August 2007)). Based on these reports, the substance was classified into Category 3.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
4	Skin sensitization	Classification not possible	- -	-	-	After three of 558 munitions workers developed lupus erythematosus, a study was conducted to investigate the relationship between the incidences and immunocompetence (ATSDR (1997)). Compared to an unexposed control group, the prevalence of antinuclear antibodies, which is a biological indicator of lupus erythematosus, was not significantly different in exposed workers (ATSDR (1997)). However, since munitions workers were also exposed to other substances including TNT and RDX in addition to this substance, no clear conclusion was drawn (ATSDR (1997)). In another study, a guinea pig skin sensitization test gave negative results, but no details such as test methods are provided. Thus, due to insufficient information available, the substance was classified into the "Classification not possible" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	While an Ames test gave negative results (IRIS (2007)), no in vivo test results are available. Thus, classification is not possible.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
6	Carcinogenicity	Not classified	- -	-	-	Based on the EPA's evaluation of the substance into Category D (IRIS (2007)), the substance was classified into the "Not classified" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In dermal administration of the substance to rabbits, the following were noted at the dose of 168 mg/kg: effects on the central nervous system including convulsions, hyperkinesias, hypokinesia, changes in aggressive behavior; histological damage to the kidney including tubular dilation, fibrosis, atrophy, and atrophy of the glomerulus (ATSDR (1997)). Since we think that damage to the central nervous system and kidney occurs at doses that fall under Category 1 guidance values, the substance was classified into Category 1 (central nervous system and kidney).	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	In a 13-week mixed diet administration test using rats, liver damage was seen in males treated with 150 mg/kg/day or higher doses, and kidney damage was noted in females treated with 270 mg/kg/day or higher doses. NOAEL were 50 mg/kg/day for males and 115 mg/kg/day for females (IRIS (1988)). The LOAEL for liver damage in males is slightly above the upper limit of Category 2 guidance values and NOAEL is within the range of Category 2 guidance values, indicating that liver damage may occur at doses that fall under Category 2. Thus, the substance was classified into Category 2 for its toxicity to the liver. Regarding female rats, the LOAEL and NOAEL for kidney damage are reported to be 270 mg/kg/day and 115 mg/kg/day, respectively. Since the NOAEL is above the upper limit of Category 2 guidance values, we determined that the substance falls under the "Not classified" category for its toxicity to the kidney.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Regarding this substance, its 96-hour EC50 for algae (Selenastrum) is > 32 mg/L, 48-hour LC50 for crustaceans (Daphnia magna) is > 32 mg/L, and 96-hour LC50 for fish (flathead minnow, rainbow trout, and bluegills) is > 32 mg/L (AQUIRE, 2007; Bentley et al., 1975). Given that its water solubility is 5mg/L (PHYSPROP Database, 2007), the substance is presumably not toxic and was classified into the "Not classified" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Any acute toxic effects are not reported for this substance up to its water solubility concentration of 5 mg/L (PHYSPROP Database, 2007), it is estimated not to be rapidly degradable (BIOWIN), and its potential for bioaccumulation is likely low (log Kow = 0.16 (PHYSPROP Database, 2007). Based on this information, the substance was classified into the "Not classified" category.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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