NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	27176-87-0
Chemical Name	Dodecylbenzenesulphonic acid
Substance ID	m-nite-27176-87-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	Due to a flash point data of 148.9 deg C (open-cup, ICSC (2002)), it is estimated that a flash point by the presbribed test method also corrresponds to "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	Because it is classified in Class 8 (corrosive substance), PG II and III (UN 2584 and 2586) in UNRTDG, it is estiamed that it does not correspond to pyrophoric substance which is hazard class with the highest precedence.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Due to the data that it is very soluble in water (ICSC (2002)), it is estimated that it does not react vigorously with water.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen which is chemically bonded to the element other than carbon or hydrogen (S), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available. Besides, it is written in ICSC (2002) that it attacks metals and "collect leaking liquid in sealable non-metallic containers."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on an LD50 value of 650 mg/kg (SIDS (2012)) for rats, this substance was classified in Category 4. Besides, this LD50 value is that of LAS C12 (linear alkylbenzene sulphonate) and is adopted in SIDS (2012) as the LD50 value for this substance.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, an LD50 value of 1,200 mg/kg (EPA RED (2006)) for rabbits has been reported. However, this was not adopted for classification since the target substance is unclear.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, an LC50 value for rats of 0.31 mg/L (EPA RED (2006)) has been reported. However, classification is not possible with this data alone since exposure time and target substance are unclear. 　Furthermore, since the LC50 value is higher than the saturated vapor pressure concentration (0.04 ng/L), a reference value as mist was applied.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is described that LAS (linear alkylbenzene sulfonates) indicates mild to moderate primary irritation in humans (EHC 169 (1996)), and is irritating at concentrations not less than 20% (EHC 169 (1996), EPA RED (2006)). 　As for reports in experimental animals, there are reports that in a skin irritation test (EPA 870.2500) using rabbits, severe irritation was observed 72 hours after application (EPA RED (2006)), and that applying 0.5 g of 0, 20 and 30% LAS to the dorsal area of rats for 15 days resulted in erythema, edema and crusts in the 30% group (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). 　On the other hand, it is concluded in SIDS (2012) that, as for LAS being mainly composed of this substance, it is slightly irritating to both the skin and the eyes and recovery is quick even at high concentration (SIDS (2012). 　From the above, this substance was classified in Category 2 because there are several reports that it is irritating.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It is reported that in an eye irritation test (EPA 870.2400) using rabbits, as a result of application of LAS (linear alkylbenzene sulfonic acid), corneal opacity was observed and was not reversed within 72 hours (EPA RED (2006)). 　In addition, in other eye irritation test using rabbits, as a result of applying 0.1mL of 0-5% LAS, severe symptoms including conjunctival edema, corneal opacity, hyperemia and so on were observed in the 5% solution group but resolved within 5 days. Therefore, it is described that LAS has a transient strong irritation but shows reversibility (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2012)). 　From the above, since severe symptoms were observed upon application at low concentrations, this substance was classified in Category 1. The information used in the previous classification was not adopted as evidence of classification because it is listed in List 3.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, as for LAS (linear alkylbenzene sulfonic acid), there are reports on a maximization test and Buehler test. It is reported that in maximization tests using guinea pigs, as a result of applying LAS (Lot A and Lot B), the rate of positive reaction was 65% in Lot A and not less than 45% in Lot B (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). In addition, there is a report that as a result of a Buehler test using guinea pigs, the percentage of positive reactions was 5% in Lot A and 0% in Lot B (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005). Moreover, it is reported that in a skin sensitization test in humans, sensitization with LAS is negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). The negative result in the OECD SIDS used in the previous classification could not be confirmed.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　As for in vivo, it is reported that in a mouse dominant lethal test, micronucleus tests using mouse bone marrow cells and chromosomal aberration tests using rat bone marrow cells are negative (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), EHC 169 (1996)). However, these results are for LAS (linear alkylbenzene sulfonic acid); and are not results focused on this substance. 　As for in vitro, bacterial reverse mutation tests and chromosomal aberration tests using cultured mammalian cells are negative (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), EHC 169 (1996)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, no adverse effects on either parent animal or pups were observed (SIDS (2012)). 　However, it is difficult to classify this substance as "Not classified" based only on this result because this study is a screening test. No other data were available for classification. Therefore, the classification was not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　There are no single exposure data for this substance in humans. 　As for animal studies, it is reported that in a single oral dose study using rats, at 1,580mg/kg, diarrhea, weakness and reduced voluntary activity prior to death were observed, but no significant gross abnormalities were seen at necropsy (SIDS (2012), SIDS Dossier (2012)). This substance was classified as "Classification not possible" since these symptoms alone are insufficient as classification evidence. Additionally, there is one reported case in which a woman who had ingested 160 ml of a 21% aqueous solution of LAS (linear alkylbenzene sulfonates: chain length unknown) with suicidal intent showed confusion, vomiting, pain in the pharyngeal and oral cavity and hypotension (EHC 169 (1996), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). In addition, in the previous classification, it was classified in Category 2 (respiratory organs) based on the description in ICSC(J) that this substance shows corrosivity to the respiratory tract. However, ICSC(J) is listed as a List 3 information source in the current GHS Classification Guidance for the Japanese Government, and no other information was obtained for the effects on the respiratory organs. Therefore, the classification result was changed.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no information in humans. 　As for experimental animals, in a combined repeated dose toxicity study with a reproduction/developmental toxicity screening test (OECD TG 422) using rats administered by gavage, squamous cell hyperplasia of the stomach is observed at or above 200 mg/kg/day, which is equivalent to Category 2 (converted guidance value: 62 mg/kg/day (calculated based on the period of 28 days which is the shortest administration period in males)); and death (one case in males), soft feces, liquid feces and soiled perineal region, a decrease in body weight and food consumption, a decrease in activated partial thromboplastin time, an increase in A/G ratio and ALT, a decrease in albumin, a decrease in absolute weight of the salivary gland and heart, forestomach erosion/ulcers are observed at 400 mg/kg/day (converted guidance value: 124 mg/kg/day (calculated based on the period of 28 days which is the shortest administration period in males)), which is above Category 2 (SIDS (2012)). 　Since it is thought that the findings in the stomach are due to stimulation, they were not adopted as the rationale for classification. 　Therefore, this substance was classified as "Classification not possible."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour EC50 = 3.4 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), it was classified in Category 2. 　Besides, a target water quality level to conserve aquatic organisms was set for linear alkyl benzenesulfonic acid and its salt (LAS) in 2013. The classification was conducted for this hazard class by adopting the data of dodecyl benzenesulfonic acid among the toxicity values which were indicated as the data available to set a target water quality level in the documents published by the Ministry of the Environment.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified as "Not classified"due to 21-day NOEC (reproduction) = 3.3 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)) although rapid degradability data on dodecyl benzenesulfonic acid were not obtained. 　If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because rapid degradability data on dodecyl benzenesulfonic acid were not obtained, and due to 96-hour LC50 = 4.5 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). 　It was classified in Category 2 by drawing a comparison between the above results.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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