NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	27355-22-2
Chemical Name	4,5,6,7-Tetrachloro-1,3-dihydrobenzo[c]furan-2-one; Phthalide
Substance ID	m-nite-27355-22-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen and chlorine (but not fluorine) in the molecule which are chemically bonded only to carbon.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a LD50 value of >10,000 mg/kg for rats (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), the substance was classified into "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >10,000 mg/kg for rats (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Although LC50 (4h) values were >4.1 mg/L (Test Data for Supporting Registration of Pesticides) and >3.94 mg/L (20% wettable preparation) for rats (Japan Society For Occupational Health (JSOH): Recommendations for allowable concentrations (2008)), classification was not possible since determination of the category was impossible. Since the test concentrations are higher than saturated vapour pressure concentration (3.3E-7 mg/L), the test was considered to be conducted for dusts.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since the substance was not irritating to the skin in a rabbit skin irritation test (GLP) (Test Data for Supporting Registration of Pesticides, Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Since in an eye primary irritation test (Draize evaluation criteria) with rabbits, conjunctivae redness (score 1) was seen at 1 and 24-hour and resolved by 48-hour after application (Test Data for Supporting Registration of Pesticides, Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	Based on results of "not skin sensitizing" in 2 skin sensitizing tests with guinea pigs (maximization test and Buehler test (GLP)) where skin reaction was not observed (positive rate: 0%) (Test Data for Supporting Registration of Pesticides), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on a negative result in a mouse bone marrow micronucleus test by oral administration (in vivo somatic cell mutagenicity test) (Test Data for Supporting Registration of Pesticides), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative CHL cell chromosomal aberration and bacterial (Salmonella typhimurium) reverse mutation tests (Test Data for Supporting Registration of Pesticides, Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	There are no classifications by other organizations for the substance. Although the substance was concluded to be non-carcinogenic in a 36-month feeding test in rats (Test Data for Supporting Registration of Pesticides), the result was obtained from a single species. Classification was not possible due to lack of sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Not classified	- -	-	-	In a three-generation reproduction test in rats, there were no effects on reproductive performance such as fertility index, gestation index or implantation, and no treatment-related morphological abnormalities of the internal organ or skeleton of fetuses were observed (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)). In a developmental toxicity test by oral administration to rabbits during organogenesis period, there were no effects on fertility index or implantation, and no teratogenic effects such as treatment-related morphological abnormalities of the internal organ or skeleton of fetuses (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations). Since no parental fertility toxicity and no fetal developmental toxicity were observed, the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	By oral administration, toxic symptoms were not observed at 10,000 mg/kg in rats or mice (Test Data for Supporting Registration of Pesticides). In addition, by dermal administration, no abnormality was noted in rats at 10,000 mg/kg (Test Data for Supporting Registration of Pesticides). Based on these data, the substance corresponds to "Not classified" with oral and dermal routes. By inhalation exposure (dust), increased nasal discharge and urinary incontinence were observed but no severe toxic effects were noted in rats at 4.1 mg/L for 4-hour (Test Data for Supporting Registration of Pesticides). However, since this test was only conducted at dose levels within the guidance value range, there is no data available for the effects at dose levels exceeding guidance value range. Classification was not possible due to lack of data with inhalation exposure routes.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Maximum non-effect levels (no observed adverse effect levels) obtained from oral administration tests are as follows: (a) rat oral (in diet) tests: 500 mg/kg day (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)) and 2500 mg/kg/day (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)) by 3-month exposure; 363 - 809 mg/kg/day by 90-day exposure (Test Data for Supporting Registration of Pesticides); and 86 - 106 mg/kg/day by 36-month exposure (Japan Society For Occupational Health (JSOH) Recommendations for allowable concentrations (2008)); (b) mouse feeding tests: 7500 mg/kg/day by 3-month exposure (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1990)); (c) dog oral (capsule) test: 1000 mg/kg/day by 90-day exposure (Test Data for Supporting Registration of Pesticides) and 100 mg/kg/day by 53-week exposure (Test Data for Supporting Registration of Pesticides). Since all rat and mouse values exceed the upper limit (100 mg/kg/day) of the guidance value range for Category 2, the substance corresponds to "Not classified" with the oral route. However, classification was not possible due to lack of data with other exposure routes.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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