Item | Information |
---|---|
CAS RN | 2768-02-7 |
Chemical Name | Vinyltrimethoxysilane |
Substance ID | m-nite-2768-02-7_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Category 2 |
Danger |
H225 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of 22 deg C (closed cup) (SIDS (2010)) and a boiling point of 123 deg C (SIDS (2010)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | It does not contain a chemical group associated with explosive properties but contains a chemical group associated with self-reactive properties (unsaturated bond), but the classification is not possible due to no data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Classification not possible |
- |
- | - | No data available. Besides, there is data on water solubility: 1,4400 mg/L (25 deg C) (estimated value) (SRC (2013)), but it was not adopted because it is an estimated value. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (Si). However, the classification is not possible due to no data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on LD50 values of 7,120 mg/kg (males), 7,236 mg/kg (females), 7,954 mg/kg (males and females) (all SIDS (2010)), and 300-2,000 mg/kg (females) (SIDS (2010), JECDB (Access on July 2013)) for rats, it was classified as "Not classified" to which most data correpond. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on LD50 values for rabbits of about 3,880 mg/kg (males) and about 3,259 mg/kg (females) (SIDS (2010)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 | P304+P340 P261 P271 P312 |
It was classified in Category 4 based on a 4-hour LC50 value of 2,773 ppmV (male and female) for rats (SIDS (2010)). Besides, because LC50 was lower than 90% of the saturated vapour pressure concentration (20,263 ppmV), a reference value in the unit of ppmV was applied as vapour with little mist. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | It was classified as "Not classified" because it is described in SIDS (2010) that it was assessed to be not irritating in three tests in which this undiluted substance was applied to rabbits (OECD TG 405, etc.). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1B |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (SIDS (2010)). As for in vitro, it was negative in both a bacterial reverse mutation test (JECDB (Access on July 2013), SIDS (2010)) and a gene mutation test (hgprt gene locus) with cultured mammalian cells (SIDS (2010)), and positive in a chromosomal aberration test with cultured mammalian cells (JECDB (Access on July 2013), SIDS (2010)). From the above data, it is concluded in SIDS (2010) that this substance is not genotoxic. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, in JECDB (Access on July 2013), data from a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test were obtained, and only in the 1,000 mg/kg bw/day group, abnormalities in estrus cycles (lower number of estrous cases in 14 days before mating, 1,000 mg/kg bw/day group: 2.5 plus or minus 0.7, control group: 3.2 plus or minus 0.4) were observed, but there were no effects on copulation index and days needed for copulation, and no effects on fertility and offspring were seen. Furthermore, because 1,000 mg/kg bw/day was the dose where death in parent animals (2/12 animals in males, 1/12 animals in females) and lower body weights were observed, it was thought that the abnormalities in estrus cycles were slight changes related to general toxicity, not reproductive toxicity. However, the test is a screening test, and there was sufficient information on developmental toxicity, therefore it was classified as "Classification not possible.". | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system), Category 3 (narcotic effects) |
Warning |
H371 H336 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
Because in inhalation exposure in rats (vapour), hypoactivity, ataxia, prostration, tremors, and reflex disorders were observed at doses (11.9-32.5 mg/L) within the guidance value range (SIDS (2010)), it was classified in Category 2 (central nervous system). Furthermore, in oral administration to rats (970-31,040 mg/kg), reversible sluggishness, piloerection, unsteady gait, etc. were found (SIDS (2010)), and in dermal exposure in rabbits (1,940-7,760 mg/kg), reversible inanimation, unsteady gait, prostration were seen (SIDS (2010)). From the above results, it was classified in Category 3 (narcotic effects). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (urinary bladder) |
Warning |
H373 | P260 P314 P501 |
It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed orally, hyperplasia of the transitional epithelium in the urinary bladder was observed at the dose (62.5 mg/kg/day (converted guidance value: 29 mg/kg/day)) within a guidance value range for Category 2 (SIDS (2010), JECDB (Access on July 2013)). Therefore, it was classified in Category 2 (urinary bladder). Besides, in a test in which rats were exposed by inhalation to the vapour of this substance for 14 weeks, there were no findings to assign a category within a guidance value range, but effects on the kidney (papillary necrosis, interstitial edema, and papillary hyperplasia of the transitional epithelium) and urinary bladder (cystitis) were observed at the dose (2.4 mg/L/6 hours/day) corresponding to "Not classified" (SIDS (2010)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | In preparation. Check the Japanese version. | FY2022 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1)) |
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