NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	28249-77-6
Chemical Name	S-4-chlorobenzyl N,N-diethylthiocarbamate [Thiobencarb]
Substance ID	m-nite-28249-77-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are four reported LD50 values for rats of 1,030 mg/kg (males), 1,130 mg/kg (females) (EPA RED (1997), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)), 1,236 mg/kg (males) and 1,289 mg/kg (females) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)) (1,240 mg/kg (males) and 1,290 mg/kg (females) were listed for the same data in Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)). Based on these data, this substance was classified in Category 4.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are the reported LD50 values for rats of > 2,000 mg/kg and > 5,000 mg/kg (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010). One value is equivalent to "Not classified" (Category 5 in UN GHS classification) - "Not classified," and the other value is equivalent to "Not classified." 　There is a report that the LD50 value for rabbits is > 2,000 mg/kg (EPA RED (1997)), and it corresponds to "Not classified" (Category 5 in UN GHS classification) - "Not classified." 　Based on these data, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. 　Besides, it is reported that the LC50 (4 hours) value for rats is > 2.43 mg/L (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010), and this corresponds to Category 4 or "Not classified." However, classification is not possible because a category cannot be specified only with this value. 　Note that the reference value as mist was applied since this LC50 value is higher than the saturated vapor pressure concentration (0.00031 mg/L).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	In a skin irritation test (details unknown) using rabbits, slight irritation has been reported (EPA RED (1997)). Moreover, in a skin irritation test (GLP test) using rabbits, the mean scores of all the animals (3 animals) at 24, 48 and 72 hours after application for 4 hours were 0.3, 0.3, 0 for erythema and crust, and 0, 0, 0 for edema, respectively. Irritation was not observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). From these results, it was thought that irritation of this substance was within the range of no irritation to very slight irritation. Therefore, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It is reported that in an eye irritation test (GLP test) using rabbits, the average scores for corneal opacity, iritis, corneal redness, cornea edema of all the animals (3 animals) at 24, 48 and 72 hours after application were 0 for all, and that no irritation was observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). It is described that in another eye irritation test using rabbits, slight irritation was observed. However, the details are unknown (EPA RED (1997)). 　Therefore, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	In a skin sensitization test (Buehler method, GLP test) using guinea pigs, sensitization was negative (sensitization rate: 0) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). Although the details are unknown, in another skin sensitization test using guinea pigs, it was also negative, and it is concluded that this substance is not a sensitizer (EPA RED (1997)). 　Therefore, this substance was classified as "Not classified."	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo data, a mouse dominant lethal test is negative, a micronucleus test using mouse bone marrow cells is positive and an unscheduled DNA synthesis test using rat hepatocytes is negative (EPA RED (1997), Evaluation of effects for food safety (Food Safety Commission, 2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). As for in vitro data, a bacterial reverse mutation test is negative, a mouse lymphoma test using cultured mammalian cells is positive, and chromosomal aberration tests have shown positive and negative results (EPA RED (1997), Evaluation of effects for food safety (Food Safety Commission, 2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). From the above, this substance was classified in Category 2 according to the GHS classification guidance for the Japanese Government.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	In 2-year carcinogenicity studies using rats and mice given this substance by feeding, no evidence of carcinogenicity has been observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010), EPA RED (1997)). The EPA classified the carcinogenicity of this substance in Group D. Therefore, this substance was classified as "Classification not possible" for this hazard class based on the classification result by the EPA.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	As for two 2-generation studies using rats given this substance by the oral route (feeding), in one study of them at doses (20 and 100 mg/kg/day) where the effects on systemic toxicity (decreased weight gain, increase in liver and kidney weights, centrilobular hepatocyte hypertrophy, regeneration and degeneration of renal tubular epithelium, etc.) in F0 and F1 parental animals were manifested, there were no adverse effects on fertility of the parent animals and occurrence and development of F1 and F2 pups (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010), EPA RED (1997)). However, in the other study, at the dose (40 mg/kg/day) where decreased weight gain was observed in F0 and F1 parental animals, a decrease in survival rate was observed in F1 and F2 pups (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)). In developmental toxicity studies using pregnant rats and pregnant rabbits dosed by the oral route (gavage, Days 6-18 of gestation), in rats, only slight effects (lower body weight, sternal variation) were observed at 150 mg/kg/day where decreased weight gain was observed in the dams, and in rabbits, there was no effect on the fetuses at up to 200 mg/kg/day where an increase in liver weights was observed in the dams (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010), EPA RED (1997)). 　From the above, in one of the two 2-generation studies using rats, a decrease in the survival rate of pups was observed at the dose where decreased weight gain occurred in the parental animals. Therefore, this substance was classified in Category 2 for this hazard class.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	It is reported that in a single oral dose study using rats, gait abnormalities, decreased mobility, decreased sensory responses, decreased hindlimb resistance and decreased average body temperature were observed at 500 mg/kg, which corresponds to Category 2, or above (EPA RED (1997)); and that calm, gait abnormality, lacrimation, prone position, hypotonia, coarse breathing, and ptosis were observed at 833 mg/kg and above (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)). Therefore, this substance was classified in Category 2 (nervous system). 　Besides the above, regarding the cholinesterase inhibitory action of this substance, there is no in vivo data, and as for in vitro, there is a description that the IC50 value for inhibition of bovine erythrocyte cholinesterase activity was > 1 mM (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver, kidney)	Warning	H373	P260 P314 P501	There is no information on humans. 　In a 90-day repeated dose toxicity study using rats given this substance by feeding, increases in alkaline phosphatase, urea nitrogen and creatinine; increased relative liver weights; centrilobular hepatocyte hypertrophy; basophilic change and hyaline droplet deposit of cortex renal tubule and casts in medullary renal tubule in the kidneys, etc. have been reported at 750 ppm (male: 44.2 mg/kg/day, female: 51.8 mg/kg/day), which is equivalent to Category 2, or above (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)). Moreover, in a 2-year carcinogenicity study using mice, an increase in diffuse pale hepatocyte and fine and large fat-containing vacuoles of the intermediate zone lobule in the liver, etc. have been observed at 100 ppm (male: 10 mg/kg/day, female: 11 mg/kg/day), which is within the range of Category 2, or above (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)). 　Besides, changes in the kidneys in rats were observed only in males, but for hyaline droplet deposit of cortex renal tubule, as a result of immunostaining of alpha 2-microglobulin was performed, no evidence that the hyaline droplet deposition was alpha 2-microglobulin was obtained (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010). Therefore, since the finding was not alpha 2-microglobulin nephropathy peculiar to male rats, the liver was regarded as the target organ. 　From the above, this substance was classified in Category 2 (liver, kidney).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From EC50 (unknown time) = 17 ppb for algae (Pseudokirchneriella subcapitata) (U.S. EPA: RED, 1997), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapidly degradable (BIOWIN), and NOEC (unknown time) = 1.0 ppb for crustacea (Daphnia magna) (U.S. EPA: RED, 1997), it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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