NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	2867-47-2
Chemical Name	2-(Dimethylamino)ethyl methacrylate
Substance ID	m-nite-2867-47-2_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Containing no chemical groups with explosive properties	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	The flash point is 74degC (open cup flash test) (NFPA (13th, 2002)), which is classified into "Category 4."	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	No data available, though containing unsaturated bonds (olefin). Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Classified as "liquid" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no "-O-O-" structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	Classified into Division 6.1 (UN#2522) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	-	- Warning	-	-	As pointed out in public comment, it is modified to "Category 5" based on two data of (LD50>2000 mg/kg, LD50=2,659 mg/kg) which is considered to have reliability in SIDS (SIAR) adopting LD50 value being larger than 2000 mg/kg.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Dermal)	-	- Warning	-	-	According to notes (f) (ii) of table 3.1.1 in the U.N. documents 3.1, it is modified to "Category 5."	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	2.28 mg/L	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is classified as "Category 1A-1C"in the three-ministry GHS division. Since UN GHS Document 3.2.2.4.2 says, "For those authorities wanting more than one designation for corrosion, up to three sub-categories are provided within the corrosive category." subdividing is not essential. It is therefore preferable to modify "Category 1A-1C" to "Category 1" from the view point of text representation as well.	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Based on the description in the report on rabbit eye irritation tests (SIDS (2003)): "within 2 hours of application, all treated animals exhibited severe corneal, iris and conjunctival damage. The present substance was thus considered to have a potential for eye corrosivity."	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	[Rationale for the Classification] Based on (1) to (3), it was classified in Category 1. Also, based on the new findings, the classification result was changed. [Evidence Data] (1) It was reported that, in a study of 1,632 patients in the dental field conducted in 1995 to 2004, a patch test with 0.2% of this substance was given to 48 patients who showed positive reactions to one or more methacrylate compounds and positive reactions were observed in 4 people (2 dental patients and 2 dental workers) (DFG MAK (2014)). (2) From several case reports indicating positive results in patch tests with this substance in patients having eczema, it could be concluded that this substance induced sensitization in humans (DFG MAK (2014)). (3) It was reported that patch tests on 79 dentists (72 women, 7 men) and 46 dental nurses (women) in Poland who were suspected of occupational allergic contact dermatitis were conducted in 1990 to 2000, and as a result, one person showed positive reactions to this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), Environmental Risk Assessment for Chemical Substances, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2006), DFG MAK (2014)). [Reference Data, etc.] (4) It was reported that, in a maximization test (OECD TG 406, GLP, intradermal induction: 1% solution) with guinea pigs (n=20), the positive rate was 0% (0/20 animals) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), Hazard Assessment Report (CERI, NITE, 2007), DFG MAK (2014), REACH registration dossier (Accessed Oct. 2021)). (5) In the ECHA, it was classified in Skin Sens. 1. (6) In the DFG, it was classified in Sh.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in Report by the Ministry of Health, Labour and Welfare (1998), SIDS (2003) and CERI Hazard Data 2001-55 (2002).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	Since the base for 3-Ministry GHS Classification is based on the changes observed from the death of mother animals (3 out of 12 animals) and the dose level (1,000mg/kg/day) where significant effects were identified, it is not appropriate to make it the base for GHS Classification. Moreover, although no effects on reproduction are observed at this dose level (200mg/kg/day), it cannot be judged whether there may be effects on reproduction or not at the dose level of 200 - 1,000mg/kg/day. Therefore, it is classified into "Classification not possible."	FY2007	GHS Classification Manual （10 Feb, 2006）/Technical Guidance Document on the GHS Classification （6 Dec, 2005）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Based on the evidence from animal studies including "reduced locomotor activity and sedation" (SIDS (2003)).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Insufficient data available	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	It was classified in Category 2 from 72-hour ErC50 = 9.0 mg for algae (Raphidocelis subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997)).	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN) and 21-day NOEC = 0.48 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained (fish), then it is classified in Category 3 due to being not rapidly degradable and 96-hour LC50 = 19 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 1997), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). By drawing a comparison between the above results, it was classified in Category 2. The classification result was revised from the previous classification by changing how to classify it in chronic toxicity and using new information.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2021	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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