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Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	298-04-4
Chemical Name	O,O-Diethyl-S-(2-ethylthioethyl) dithiophosphate [Disulfoton]
Substance ID	m-nite-298-04-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	Although a flash point of 133 deg C (unknown method) (GESTIS (Access on July 2017)) is from unknown method, it is judged that it will be above 93 deg C also in the proscribed closed-cup method. Therefore, it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metalloids (P), but it is estimated that it does not react vigorously with water from the measurement data of water solubility of 16.3 mg/L (20 deg C) (HSDB (Access on July 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 1	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	There are five reports of LD50 values of 2.0 mg/kg (female) (JMPR (1975)), 2.3 mg/kg (female) (ACGIH (7th, 2002)), 2.6 mg/kg (female) (JMPR (1973)), 6.8 mg/kg (male) (ACGIH (7th, 2002)), 12.5 mg/kg (male) (JMPR (1973)) for rats, 3 data correspond to Category 1, and 2 data correspond to Category 2. It was classified in Category 1 by adopting the category with the largest number of cases.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Based on reports of LD50 values of 2.5-50 mg/kg (male) (JMPR (1973)), 15 mg/kg (male) (ACGIH (7th, 2002)) for rats, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, the saturated vapor pressure concentration of this substance of 0.20 ppm (0.0022 mg/L) is extremely low, therefore, it is considered that the possibility of exposure to vapor is low. It was classified as "Not applicable" in the previous classification, but, this substance is liquid in the GHS definition, therefore, the classification result was changed.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	There are reports of LC50 values for rats of 0.015 mg/L (1.34 ppm) (female) and 0.06 mg/L (5.34 ppm) (male) (ACGIH (7th, 2002)) in 4-hour inhalation exposure tests, and 0.063 mg/L (5.6 ppm) (converted 4-hour equivalent value: 0.016 mg/L) (female) and 0.29 mg/L (25.8 ppm) (converted 4-hour equivalent value: 0.073 mg/L) (male) (ACGIH (7th, 2002)) in 1-hour inhalation exposure tests, 2 data correspond to Category 1, and 2 data correspond to Category 2. The category with higher hazard was adopted, and it was classified in Category 1. Besides, since the exposure concentrations were higher than the saturated vapor pressure concentration (0.0022 mg/L (0.20 ppm)), the reference values in the unit of mg/L were applied as mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on the descriptions that it is severely irritating to human skin (EPA Pesticide (2006), HSDB (Access on June 2017)), it was classified in Category 2. The category was revised based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there are descriptions that it severely irritating to the eyes (EPA Pesticide (2006), HSDB (Access on June 2017)), the original sources cannot be confirmed and the details of the test are unknown, therefore it was classified as "Classification not possible." The category was revised based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there is a description that it is a severe sensitizer to the skin (EPA Pesticide (2006)), the original source cannot be confirmed, and the content of the test is unknown, therefore, it was classified as "Classification not possible." The category was revised based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese Government. As for in vivo, the results were negative in a dominant lethal test with mice and a micronucleus test with mouse bone marrow cells (ATSDR (1995)). As for in vitro, the results were positive and negative in bacterial reverse mutation tests, negative in a mammalian cell gene mutation test, positive in a mouse lymphoma test, positive and negative in sister chromatid exchange tests (ATSDR (1995)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	It is described that histological evidence of carcinogenicity was not found in carcinogenicity tests in which rats were dosed by feeding for two years, and mice were dosed by feeding for 99 weeks at up to 16 ppm (ACGIH (7th, 2002)). As for the classification results by other organizations, it was classified as group E by EPA in 1997 (Chemicals Evaluated for Carcinogenic Potential, Annual Cancer Report (2016)), it was classified as A4 by ACGIH in 2002 (ACGIH (7th, 2002)). From the above, based on the latest classification result by ACGIH, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a test out of two 2-generation studies with rats dosed by feeding, at a high dose (9 ppm), a decrease in weight gain and a decrease in fertility index in F0, F1 dams, a decrease in viability in F1 and F2 pups were observed (Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006), ACGIH (7th, 2002)); in the other one, at a high dose (9 ppm), a decreased number of implantations and a decreased litter size together with death, a decrease in weight gain, and tremors in F0 and F1 dams were observed (ACGIH (7th, 2002)). On the other hand, in a developmental toxicity test with pregnant rats dosed by gavage during the organogenesis period (gestational day 6-15), depressions of plasma and red blood corpuscle cholinesterase activity were observed in maternal animals at or above 0.3 mg/kg/day, but only slight effect (delayed ossification) was observed in fetuses even at a high dose (1.0 mg/kg/day) (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), ACGIH (7th, 2002)). In addition, also in developmental toxicity tests with pregnant rabbits, neither fetal toxicity nor teratogenicity was observed at doses where maternal toxicity (death, tremor, etc.) was found (ACGIH (7th, 2002)). As described above, in the 2 cases of 2-generation studies with rats, reproductive and developmental effects (a decreased fertility index, a decreased litter size, a decrease in viability of pups) were observed at the dose where general toxicity in parental animals manifested, therefore, it was classified in Category 2 for this hazard class.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is an organophosphorus insecticide, and it inhibits cholinesterase (ACGIH (7th, 2002)). As for humans, it reported that as acute toxic symptoms due to the exposure to this substance by oral, dermal and inhalation, blurred vision, headache, dizziness, pinpoint pupils, muscle spasms, and weakness were observed, and higher levels of exposure can produce vomiting, abdominal pain, diarrhea, tremors, and coma (ACGIH (7th, 2001)). It is reported that as symptoms of respiratory impairment, respiratory paralysis can occur in addition to shortness of breath and respiratory depression (ACGIH (7th, 2001)). As for experimental animals, it was reported that in single exposure tests with rats dosed by oral, dermal and inhalation, convulsive seizures, prostration, and respiratory failure were observed following excitability, salivation, lacrimation, urination, defecation, and muscular fasciculations (JMPR (1973), ACGIH (7th, 2002)). Although there is no detailed description of the dose at which the effect was observed in the animal tests, since the LD50 value and the LC50 value correspond to the range for Category 1, it is considered that the effect was observed at the dose near the LD50 value and the LC50 value within the range for Category 1. From the above, it was classified in Category 1 (nervous system).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	No information on humans is available. As for experimental animals, in a 13-week inhalation toxicity test with rats (6 hours/day, 5 days/week), at 1.4 mg/m3 (converted guidance value: 0.001mg/L) within a guidance value range for Category 1, inhibition of plasma, erythrocyte, brain cholinesterase activities and inflammation in the nasal turbinate were observed (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 1991), JMPR (1991)). In a 13-week toxicity test with rats dosed by feeding, at or above 4 ppm (male: 0.27 mg/kg/day, female: 0.32 mg/kg/day) within the guidance value range for Category 1, inhibition of brain, plasma, and erythrocyte cholinesterase activities (comparing with the control group, it inhibited 20% or more) was observed; and at 16 ppm (male: 1.1 mg/kg/day, female: 1.3 mg/kg/day), cholinergic signs (muscular fasciculations, tremors, decreased forelimb grip strength, perianal stains, defecation) were observed (ACGIH (7th, 2002)). In a 2-year toxicity test with rats dosed by feeding, at or above 1 ppm (0.04 mg/kg/day) within the guidance value range for Category 1, inhibition of erythrocyte and brain cholinesterase activity was observed; at or above 4 ppm (0.165 mg/kg/day), optic nerve degeneration and cystic degeneration of the Harderian gland were observed; at 16 ppm (0.65 mg/kg/day), an increase in mortality rate, cholinergic signs, increased relative brain weight, mucosal hyperplasia and chronic inflammation of the forestomach, and corneal neovascularization were observed (ACGIH (7th, 2002), JMPR (1991), Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006), IRIS (1987)). In a 3-week, dermal application test with rabbits, at 6.5 mg/kg/day (converted guidance value: 1.08 mg/kg/day) within a guidance value range for Category 1, cholinergic effects (muscle spasms, dyspnea, salivation), deaths, and inhibition of plasma and erythrocyte cholinesterase activities were observed (JMPR (1991)). As described above, optic nerve degeneration was regarded as the effect on the nervous system, and inflammation in the nasal turbinate was regarded as the effect on the respiratory organs. Thus, it was classified in Category 1 (nervous system, respiratory organs). By using new information sources, the classification result was different from the previous one.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 48-hour EC50 = 0.013 mg/L for crustacea (Daphnia magna) (EPA AQUIRE: 2017, Pesticide Ecotoxicity Database), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Due to being not rapidly degradable (BioWin), and 21-day NOEC (reproduction inhibition) = 0.000037 mg/L for crustacea (Daphnia magna) (EPA AQUIRE: 2017, EPA Pesticide Ecotoxicity Database), it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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