NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	32534-81-9
Chemical Name	diphenyl ether, pentabromo derivative pentabromodiphenyl ether
Substance ID	m-nite-32534-81-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified	- -	-	-	The substance is documented to be nonflammable (ICSC (J) (2005)), and it is a flame retardant additive (ATSDR (2004)). In addition, there is a description that as a result of combustion tests, it is categorized into incombustible material (Ullmanns (E) (6th, 2003)). Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified	- -	-	-	The substance is documented to be nonflammable (ICSC (J) (2005)), and it is a flame retardant additive (ATSDR (2004)). In addition, there is a description that as a result of combustion tests, it is categorized into incombustible material (Ullmanns (E) (6th, 2003)). Thus, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Since it is nonflammable (ICSC (J) (2005)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on its rat LD50 values: 500-5000 mg/kg bw, 2640 mg/kg bw, 5000 mg/kg bw, 5800 mg/kg bw (female), 6200 mg/kg bw and 7400 mg/kg bw (male) (JECFA (2005)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	In rabbits that were exposed to the substance for 4 hours, one of six treated animals showed erythema of score 1 level, 24 hours after exposure (EU-RAR No. 15 (2002)). Based on this result, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	In rabbit tests, very slight chemosis and conjunctival redness were observed (EU-RAR No. 15 (2002)). In rat tests, slight evidence of corneal damage was shown (ATSDR (2004)). Based on these outcomes, the substance was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	Of two maximization tests conducted using guinea pigs, one test resulted that 3 of 15 treated animals developed very slight erythema 48 hours after administration, and the symptom remained unhealed for 72 hours in one animal (EU-RAR No. 15 (2002)). In the other test, no sensitization occurred in either treated or control groups (EU-RAR No. 15 (2002), In addition, it has been concluded that this substance does not possess significant skin sensitization potential (EU-RAR No. 15 (2002)). Based on these reports, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in micronucleus tests using peripheral blood of mice (in vivo mutagenicity tests using somatic cells) (NTP DB (accessed in February 2009), the substance was classified into "Not classified". With respect to in vitro mutagenicity tests, one Ames test resulted that mutagenic effects were induced in TA1535 and TA1538 colonies that were not metabolically activated at high concentrations (JECFA (2005)). However, other in vitro tests: different Ames tests and chromosome analyses using human lymphocytes, gave negative results (JECFA (2005), EU-RAR No. 15 (2002), NTP DB (accessed in February 2009)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	In developmental toxicity tests by means of oral administration (mixed diet) tests using rats or forced oral administration tests, no abnormalities were observed in terms of body weight, male fetal ratio per litter, change in external appearance or teratogenicity (EU-RAR (2002)). However, since no detailed information on sexual functions of parental animals is available, the substance was classified into the "Classification not possible" category. Regarding effects on lactation, it has been documented in human epidemiological surveys that the substance moves through fat tissue into the mother's milk (HSDB (2003)). In neuroethological studies targeting neonatal mice, differences in behavioral patterns were detected between treated and control animal groups in measurements on spontaneous behavior conducted 2 and 4 months after administration, and in Morris swim maze tests conducted 5 months after administration (ATSDR (2004), EU-RAR (2002)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	In oral administration tests using rats, necrosis of the liver was observed at doses of 2640 mg/kg bw, 5800 mg/kg bw (male), 6200 mg/kg bw and 7400 mg/kg bw (female), which are higher than Category 2 guidance doses (JECFA (2005), EU-RAR No. 15 (2002)). Although an increase in organ weight and activation of enzymes have been recognized to occur at 500 mg/kg bw or lower doses (JECFA (2005), EU-RAR No. 15 (2002)), the effects of the substance within the guidance doses is not clear. Thus, the substance was classified into "Classification not possible".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Category 1 (thyroid)	Danger	H372	P260 P264 P270 P314 P501	In 28-day forced oral administration tests using rats, secretion of total thyroxine and free thyroxine, both constitutes of thyroid hormone drastically dropped at 25 mg/kg/day bw (90-day conversion: 8 mg/kg bw), which falls under Category 1 guidance doses (JECFA (2005)). Of 4-week and 13-week oral administration (mixed diet) tests using rats, both 4-week (conversion value: 1.67 mg/kg) and 13-week (conversion value: 5 mg/kg) administration were associated with reversible, mild hyperplasia of the thyroid gland (EHC (J) No. 162 (1994), JECFA (2005)). Thus, the substance was classified into Category 1 (thyroid gland). Also, 4-week and 90-day oral administration tests (mixed diet and forced oral administration) using rats, an increase in liver weight, enlargement of parenchymal liver cells, the presence of granular structures, and eosinophilic "round bodies" in the cytoplasm were observed at the dose of 5 mg/kg/day; however, these changes were considered too subtle that evaluation was not conducted (JECFA (2005)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classification is not possible due to lack of appropriate data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classification is not possible due to lack of appropriate data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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