NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	330-54-1
Chemical Name	3-(3,4-Dichlorophenyl)-1,1-dimethylurea; Diuron
Substance ID	m-nite-330-54-1_v3
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
7	Flammable solids	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (HSDB (Access on May 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
10	Pyrophoric solids	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (HSDB (Access on May 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It was classified as "Not classified" from information that it is not combustible (HSDB (Access on May 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Classification is not possible because test methods applicable to solid substances are not available.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
17	Desensitized explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1) - (5). [Evidence Data] (1) LD50 for rats: males: 3,400 mg/kg (ACGIH (7th, 2001), HSDB (Access on May 2020)) (2) LD50 for rats: females: 4,150 mg/kg (REACH registration dossier (Access on September 2020)) (3) LD50 for rats: males: 4,721 mg/kg, females: > 5,000 mg/kg (EPA Pesticides RED (2003)) (4) LD50 for rats: 4,780 mg/kg (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 9 (Japan Crop Protection Association, 1991)) (5) LD50 for rats: males: 4,990 mg/kg, females: 5,060 mg/kg (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)) [Reference Data, etc.] (6) LD50 for rats: 1,017 mg/kg (HSDB (Access on May 2020)) (7) LD50 for rats: 1,020 mg/kg (GESTIS (Access on May 2020))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) LD50 for rats: > 2,000 mg/kg (EPA Pesticides RED (2003), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)) (2) LD50 for rats: > 5,000 mg/kg (GESTIS (Access on May 2020)) (3) LD50 for rats: > 7,000 mg/kg (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 9 (Japan Crop Protection Association, 1991))	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	[Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified."	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). Besides, because exposure concentrations were higher than the saturated vapor pressure concentration (1.0E-007 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) LC50 for rats (4 hours): > 5.05 mg/L (REACH registration dossier (Access on September 2020)) (2) LC50 for rats (4 hours): > 7.1 mg/L (EPA Pesticides RED (2003)) (3) Vapor pressure of this substance: 8.25E-009 mmHg (25 deg C) (HSDB (Access on May 2020)) (converted value for the saturated vapor pressure concentration: 1.0E-007 mg/L)	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1) - (3). The classification result was changed due to new data (1) - (3) obtained. [Evidence Data] (1) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, all irritation reactions cleared by 72 hours (EPA Pesticides RED (2003)). (2) In an irritation test on the forearms of human volunteers, no irritation was seen (GESTIS (Access on May 2020)). (3) In a skin irritation test with rabbits according to OECD TG 404, the mean score at 24/48/72 hours after application was all 0 (REACH registration dossier (Access on September 2020)). [Reference Data, etc.] (4) This substance may irritate the skin and eye in humans (ACGIH (7th, 2001), HSDB (Access on May 2020)). (5) In a skin irritation test with rabbits by 24-hour application, it was irritating (GESTIS (Access on May 2020)). (6) In a skin irritation test in which 50% paste (0.05 g) of this substance was applied to the guinea pig skin, it was slightly irritating (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). The classification result was changed due to new data (1), (2) obtained. [Evidence Data] (1) In an eye irritation test with rabbits according to EPA OPPTS 870.2400, all irritation reactions cleared by 48 hours (EPA Pesticides RED (2003)). (2) In an eye irritation test with rabbits according to OECD TG 405, the mean score at 24/48/72 hours after application was all 0 (REACH registration dossier (Access on September 2020)). [Reference Data, etc.] (3) This substance may irritate the skin and eye in humans (ACGIH (7th, 2001), HSDB (Access on May 2020)). (4) In an eye irritation test with rabbits, it was irritating (GESTIS (Access on May 2020)). (5) The wettable powder of this substance may irritate the eyes (HSDB (Access on May 2020)). (6) The 80% wettable powder of this substance was slightly irritating in an eye irritation test with rabbits (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
4	Skin sensitization	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1) - (4). [Evidence Data] (1) This substance was reported to be negative in a skin sensitization test in guinea pigs (ACGIH (7th, 2001)). (2) It was reported to be negative in a skin sensitization test in guinea pigs according to EPA OPPTS 870.2600 (EPA Pesticides RED (2003)). (3) It was reported to be negative in a skin sensitization test in guinea pigs (maximization test) (GESTIS (Access on May 2020), REACH registration dossier (Access on September 2020)). (4) In a skin sensitization test in guinea pigs in which 50% paste (0.05 g) of this substance was applied nine times, it was reported to be negative (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
5	Germ cell mutagenicity	Not classified	- -	-	-	[Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) As for in vivo, it was reported to be negative in a chromosomal aberration test with bone marrow cells after oral administration to rats (HSDB (Access on May 2020), EPA Pesticides RED (2003)). (2) As for in vitro, it was reported to be negative in a bacterial reverse mutation test (HSDB (Access on May 2020), Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 9 (Japan Crop Protection Association, 1991)), negative in a chromosomal aberration test with cultured mammalian cells (Agricultural Chemicals Times supplement "Agricultural chemicals technology information" No. 9 (Japan Crop Protection Association, 1991)), and negative in a gene mutation test (HSDB (Access on May 2020)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
7	Reproductive toxicity	Not classified	- -	-	-	[Rationale for the Classification] Based on (1) to (4), it was classified as "Not classified." [Evidence Data] (1) In a three-generation reproductive toxicity study with rats by feeding, no effect was observed (Agricultural Chemicals Times supplement, "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)). (2) In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, no reproductive effects were observed even at a dose at which parental toxicity (a decrease in body weight, anemia, an increase in hemosiderosis, an increase in extramedullary hematopoiesis in the spleen, hemosiderosis in Kupffer cells in the liver, etc.) was observed (Safety Test (Ministry of Economy, Trade and Industry (METI), 2009)) (3) In a developmental toxicity study with female rats dosed by gavage on days 6 to 14 of gestation, a decrease in fetal body weight and delayed ossification (vertebra, sternum) were observed in fetuses at a dose at which maternal toxicity (a decrease in food consumption, a decrease in body weight, etc.) was observed (Agricultural Chemicals Times supplement, "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)). (4) In a developmental toxicity study with female rabbits dosed by gavage on days 7 to 19 of gestation, miscarriage (1 case) was observed but no effect was observed in fetuses at a dose at which maternal toxicity (reduced body weight gain, a decrease in body weight, a decrease in food consumption) was observed (Agricultural Chemicals Times supplement, "Agricultural chemicals technology information" No. 8 (Japan Crop Protection Association, 1991)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
8	Specific target organ toxicity - Single exposure	Category 3 (Respiratory tract irritation)	Warning	H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	[Rationale for the Classification] Based on (1), it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) This substance may irritate the skin, eyes, and throat (HSDB (Access on May 2020)). [Reference Data, etc.] (2) This substance may irritate the eyes (ACGIH (7th, 2001)).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system), Category 2 (urinary organs)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 72-hour ErC50 = 0.025 mg/L for algae (Raphidocelis subcapitata) (Document for registration standards for agricultural chemicals set by the Minister of Environment to prevent harm to animals and plants in areas of public waters, 2013).	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 because it was not rapidly degradable (a 28-day degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1988)) and due to 35-day NOEC = 0.001 mg/L for fish (Danio rerio) (REACH registration dossier, 2020). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 because it was not rapidly degradable (a 28-day degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1988)) and due to 48-hour EC50 = 1.4 mg/L for crustacea (Daphnia magna) (EU REACH CoRAP, 2016). By drawing a comparison between the above results, it was classified in Category 1.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2020	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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