NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	334-88-3
Chemical Name	Diazomethane
Substance ID	m-nite-334-88-3_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Ignitable if there is an ignition source, because of "its auto-ignition temperature: 100degC" (ICSC(J), 1995)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified	- -	-	-	Not oxidizing gas because of flammable gas	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Impossible to store or transport as pure articles	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Classification not possible	- -	-	-	It cannot be classified. Since concentration is unknown in rat inhalation exposure, test time of others is slight, and there is no valid data used for classification. (In these exposure examinations, having died for a short times, and death in 10 minutes in cat inhalation study at 175ppm (4 hour equivalent: 35ppm). It seems that treating as Category 1 is desirable since this is less than 100ppm of Category 1.)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified as Category 2 as it was reported that there is stimulativeness and denudation on human skin (ACGIH (2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since there was a case of severe inflammation (critical inflammation) to humans, it was set as Category 1. (DFGOT vol.13(1999)	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Based on the case which caused the attack of asthma in humans(ACGIH (2001)) respiratory sensitization was referred to as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Skin sensitization was set to Category 1 since sensitization was identified in guinea pigs (PATTY (5th, 2001)). Diazomethane is defined as a sensitizing chemical substance in the interim report of the Japanese occupationl and environmental allergology meeting's specially committee .	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although it showed mutagenicity for the in vitro information (DFGOT vol.13 (1999)), there was no in vivo data. Therefore we could not classify it.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] This substance is a strong irritant which causes damage to the respiratory organs even at lower concentrations (DFGOT Vol. 3 (1999)). Therefore, tests for carcinogenicity assessment are limited to short-time exposure tests, and classification results in (4) are reported from limited animal test results (1)-(3). From (4), the classification result by ACGIH, which classified later than IARC did, was prioritized, and the substance was classified in Category 1B. The category was revised by the use of new information sources. [Evidence Data] (1) As the result of inhalation exposure in male rats (total 13 animals) of two strains to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for 2-3 minutes, twice weekly for six or 4.5 months, pulmonary adenoma was found in three out of seven animals which survived longer than 10 months, and one of these three showed squamous cell carcinoma of the lung which was invasive/metastatic to the diaphragm and skeletal muscle (IARC 7 (1974), DFGOT Vol. 3 (1999)). (2) As the result of inhalation exposure in male mice of the A strain (12 animals) to the vapour from an ether solution of this substance (0.1-3.3 mg/L) for about three minutes (reduced to two minutes after 10 days when deaths of animals occurred), twice weekly for six months, pulmonary adenoma was observed in 7/10 of mice which survived longer than six months (the control group: 2/8 animals). Moreover, as the result of inhalation exposure in male mice of the Swiss strain (five animals) to the vapour of this substance similarly generated for 1.5 minutes/time, 12 times in the first six weeks, lung tumors were observed in all the five animals which survived for six months (the control group: 3/6 animals) (IARC 7 (1974), DFGOT Vol. 3 (1999)). (3) After a few drops of an ether solution of this substance (0.1-3.3 mg/mL) were dermally applied on the dorsal skin of male mice of the A strain (12 animals) five times/week for five months, lung adenoma was observed in all the eight survived animals (IARC 7 (1974), DFGOT Vol. 3 (1999)). (4) IARC described there is limited evidence in experimental animals above and classified it in Group 3 (IARC Suppl. 7 (1987)). It is written in ACGIH that lung adenoma in mice and pulmonary adenoma and squamous cell carcinoma in rats were observed under condition similar to worker exposure, warrant to A2 designation for carcinogenicity classification (ACGIH (7th, 2001): classification in 1996). Other than these, it was classified in 1B in EU CLP. [Reference Data, etc.] (5) The Ministry of Health, Labour and Welfare judged that A2 classification by ACGIH is appropriate, and this substance is probably carcinogenic to humans (Hazard Assessment Table (Ministry of Health, Labour and Welfare, 2010)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system), Category 2 (spleen, liver)	Danger Warning	H370 H371	P308+P311 P260 P264 P270 P321 P405 P501	There is cases, such as pneumonia, pulmonary oedema, difficulty breathings, cyanosis, chest pain, asthma, and generation of heat, are regarded in humans (ACGIH (2001), PATTY (5th, 2001), IARC 7 (1974)), so it is classified into Category 1. Moreover, in the examination of a rat, atelectasis, purulence and hyperemia of bronchus, emphysema, dysplasia of bronchus mucosa, etc., moreover, congestion and expansion of spleens, nephrotic changes in half of liver cortex inner side, and ongestion of glomerulus (IARC 7 (1974), DFGOT vol.13 (1999)). Thereby, it is classified into Category 2 (a spleen, liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It cannot be classified, accoding to that in the human case, there are the examples that pulmonaru edema, asthma, respiratory distress, cyanosis, and a tremor has come out and, died and the other hand recover ten days afterward (DFGOT vol.13 (1999)). These occupational exposure is considered to be the results out of which the symptom of acute toxicity (single exposure) came.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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