Item | Information |
---|---|
CAS RN | 35400-43-2 |
Chemical Name | O-ethyl O-(4-methylthiophenyl) S-propyl dithiophosphate |
Substance ID | m-nite-35400-43-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecules. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified |
- |
- | - | Not classified because it "may burn but does not ignite readily (HSDB, 2005)" | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It carried out the outside of Category by the statement of may burn but does not ignite readily (HSDB (2005)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Since there is a data of water solubles, it carried out the outside of Category for not being water reactive. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus (but not fluorine and chlorine). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no -0-0- structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
SPECIES: Rat ENDPOINT: LD50 VALUE: 100-300mg/kg REFERENCE SOURCE: ACGIH (2001) SPECIES: Rat ENDPOINT: LD50 VALUE: 107-304mg/kg (male), 65-275mg/kg (female) REFERENCE SOURCE: PATTY (5th, 2001) |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 | P302+P352 P361+P364 P280 P312 P321 P405 P501 |
It was classified into Category 3 from the description of rabbit LD50: male 820m/kg, female 994mg/kg (PATTY (5th, 2001)) and 800 - 1000 mg/kg (ACGIH (2001)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | There is no data, and it cannot be classified. (generation of vapor can be disregarded in room temperatures.) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | There is no data and it cannot classify. (There is a data of mouse and hamster LC50 >0.49mg/L/4H (PATTY (5th, 2001)), and Category 3 and 4 can be assumed. ) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | It was classified as out of Category from the statement of having no stimulativeness on the examination with rabbits (ACGIH (2001)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | It was set as the outside of Category from the statement of having no stimulativeness (ACGIH (2001)) by the examination of the rabbit. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classified as uncategorizable because of no data. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | Classified as out of category because the guinea pig test using a pure product came negative. (A test using an end-use product can result positive.) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Because of the reports indicating negative results in the dominant lethal test in mice (ACGIH (2001)), the mouse micronucleus test (PATTY (5th, 2001)) and in the in vitro test (the Ames test, sister chromatid exchange test) (ACGIH (2001), PATTY (5th, 2001)). So the substance was regarded as outside the categories. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Not classified |
- |
- | - | There is the description that carcinogenicity was not observed in mouse and dog test (PATTY (5th, 2001)). And it was set as the outside of Category from being classified into A4 according to ACGIH. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Not classified |
- |
- | - | The fetotoxity and teratogenicity were not observed but maternal toxicity (feed consumption and weight reduction) was observed (ACGIH(2001)) in the pregnant animals oral administration test of rat and rabbit, maternal toxicity, ferotoxity and teratogenicity was not observed in the pragnant animals oral administration test of rat (PATTY (5th, 2001)), and reproductive toxicity was not observed in three generation test of rat (inhalation exposure) (ACGIH(2001)). Based on the above, it was put on the outside of category. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Suppression of the central nervous system, such as headaches, dizziness, convulsions and respiratory failure are observed, and other effects on the nervous system, such as constriction of the pupils, arrhythmia and muscle spasms, are observed as acute toxicity symptoms in humans (EHC 63 (1986), ICSC (1993), HSDB (2005)). Moreover, there is the report of suppression of cholinesterase activity in sera, erythrocytes and the brain within the guidance values for Category 1 in the single-dose study (PATTY (5th, 2001)). So the substance was classified as Category 1 (nervous system). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Since in the repeted oral or inhalation administration with rat, inhibition in cholinesterase activities was observed within the guidance value of Category 1(ACGIH (2001), PATTY (5th, 2001)), and as a human chronic toxicity symptoms, because of the description of headaches, weakness, failure of memory, a sleep disturbances, decreased appetite, disorientation, and hand and foot trembling etc (HSDB (2005)). Based on these results it was classified into Category 1 (nervous system) . | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 48-hour EC50= 0.75ppb of Crustacea (Daphnia magna) (AQUIRE, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity is Category 1, supposed not rapidly degrading (BIOWIN), and bioaccumulative (log Kow=5.48 (PHYSPROP Database, 2005)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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