NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	3689-24-5
Chemical Name	sulfotep
Substance ID	m-nite-3689-24-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified	- -	-	-	Although it was combustible, since the data on flash point was not found, based on the UNRTDG class 6.1, it was considered as out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Not classified based on UNRTDG Class: 6.1, though containing P-O bonds as chemical groups associated with self-reactive properties present	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Based on the UNRTDG class 6.1, it carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	Not classified because of UNRTDG Class: 6.1 though containing oxygen bonded to other than carbon and hydrogen.	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Although there is a statement (Merck (13th, 2001)) of corroding steel, since there is no rest of database, it cannot be classified.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	It was set as Category 2 based on LD50=5.35 mg/kg. This value was calculated by ten data of rats(ACGIH(2005), DFGOT vol.13(1999)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 1	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	Rat LD50 = 262mg/kg (ACGIH (2005), DFGOT vol.13 (1999)), was compared with the lower LD50 = 5mg/kg among rabbit two data (ACGIH (2005), DFGOT vol.13 (1999)). And it was set as Category 1 based on the lower LD50 = 5mg/kg.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Since the saturated vapor pressures concentrations pressure of this product is 0.2ppm, it is thought that the inhalation experiments was conducted in mist conditions. Based on LC50 = 0.038mg/L which is lower value among two rat data (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)), it was set as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There are results that skin irritation was not observed on rabbit (ACGIH and (2005), DFGOT vol.13 (1999), and PATTY (5th, 2001)), however, there are many descriptions on humans that it stimulates skin and causes disorder (ACGIH (2005), ICSC (J), (1999), HSDB (2005), HSFS (2000), SITTIG (2002)). Since there was no statement about the disorder and concrete description or a grade of the stimulativeness on humans, taking the larger side with danger, it was classified as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Based on a statement although a stimulus and redness were acknowledged in the eye with the rabbit, it recovered within 24 hours (ACGIH and (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)), and that an eye was stimulated in humans and pains and blurred visions were produced (ICSC (J), (1999), HSFS (2000), SITTIG (2002)), it was set as Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	Although there was a statement that contact dermatitis was produced by chronic exposures in humans(HSDB (2005)), it was the only statement on hand and the number of cases was unknown. Therefore, it was decided that it could not be classified due to the insufficiency of data..	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Not classified	- -	-	-	We found no results of human over generation epidemiology, and it gave negative for the dominant lethality examination with the mouse (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001), negative for the micronucleus test with mouse bone marrow cells (DFGOT vol.13 (1999), PATTY (5th, 2001)). Therefore we classified it as Out Of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	Based on being classified into A4 according to ACGIH (ACGIH (2005)), it considered as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It is observed that no effects on reproduction of parents and development and growth of offsprings in multiple organogenetic period administration tests in rats and rabbits(ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)) and in a rat two-generation administration test (DFGOT vol.13 (1999), but it is observed increase empryo absortion and decrease fetal weight at dose occuring toxicity on maternal animal in one rat organogenetic period administration test (DFGOT vol.13 (1999)). Based on this data, it was classified into class 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	In many studies using rat, mouse, rabbit, dog and cat, there is the description about the symptoms of typical organophosphorus compound toxicity, and inhibition of cholinesterase in the central and peripheral nerve, in the dose in the range of the guidance value of Category 1 (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)). There is the description about the symptoms of phosphororganic compound toxicity as headache, malevolence/vomiting, diarrhea, dizziness, weakness, muscular pain, anxiousness, closeness, salivation, lachrymation, drowsiness in human (ACGIH (2005), PATTY (5th, 2001)). Moreover, there is a description that "stimulating lungs and producing coughing and closeness in the inhalation" at humans (HSFS (2000)). It is classified into Category 1 (nervous systems) and 3 (respiratory irritation) from the above thing.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, lung)	Danger	H372	P260 P264 P270 P314 P501	It was classified to as Category 1 (nerve systems) based on that in oral study to rats and dogs, with the dosage of guidance value within the limits of Category 1, cholinesterase inhibition in red corpuscles and/or plasma and relevant symptoms such as the convulsion, tremor, vomiting and diarrhea etc., were observed (ACGIH (2005), DFGOT vol.13 (1999), PATTY (5th, 2001)). Moreover, it was classified to as Category 1 (lungs) based on that in the rat inhalation test with the dosage of guidance value within the limits of Category 1, pulmonary edema and relevant the increase in weight (absolutely weights and relative weights) of the lungs is observed (ACGIH and (2005),DFGOT vol.13 (1999) and PATTY (5th, 2001)).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified into Category 1 from 48-hour LC50=0.23microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003).	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.99(PHYSPROP Database, 2005)).	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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