NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	3710-84-7
Chemical Name	N,N-Diethylhydroxylamine [diethylhydroxylamine]
Substance ID	m-nite-3710-84-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	It contains a chemical group associated with explosive properties (NO), but due to an oxygen balance below -200 (-225), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	From flash point data of 45 degrees C (method unknown) (GESTIS (Access on June 2015)), it is estimated that it corresponds to Category 3 in a prescribed test.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Although it contains a chemical group associated with explosive properties (NO), the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (N), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an organic compound that does not contain bivalent -O-O- structure in the molecule.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Due to no data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From a reported LD50 value of 2,190 mg/kg for rats (ACGIH (7th, 2013)), it was classified as "Not classified" (Category 5 in UN GHS classification).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P362+P364 P280 P312 P321 P501	From a reported LD50 value of 1,300 mg/kg for rabbits (ACGIH (7th, 2013)), it was classified in Category 4.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	From a reported LC50 value (4 hours) of 3,140 ppm for rats (ACGIH (7th, 2013)), it was classified in Category 4. Besides, a reference value in the unit of ppm was applied as vapour without mist because the LC50 value is lower than 90% of the saturated vapour pressure concentration (4,421 ppm).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	It is reported that in a test in which undiluted solution of this substance was applicated for 4 hours to rabbits (49 CFR 173.240), no clear signs showing irritation were observed in any animals (6) (US EPA/HPV Challenge program (2005)). Moreover, slight irritation (ACGIH (7th, 2001)) or no irritation (ACGIH (7th, 2013)) was reported for rabbits. Therefore, it was judged to be "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported in two reports from eye irritation tests using rabbits (Draize test) that as a result of applying 0.1 mL of undiluted solution of this substance into the conjunctival sac of rabbits, irritation was limited to conjunctival redness without edema which disappeared completely within 24 hours, and that moderate conjunctivitis was observed but resolved within 72 hours (US EPA/HPV Challenge program (2005), ACGIH (7th, 2001)). From the above results, it was classified in Category 2B.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Not classified	- -	-	-	In a Buehler test using guinea pigs (EPA/OPP 81-6, GLP compliance), skin reaction was not observed in either a test group applied a 30% aqueous solution of this substance or a control group 24 and 48 hours after a challenge, and a positive rate was 0% for both groups (0/10 and 0/5 respectively). A positive control group showed erythema in all sites 24 and 48 hours after a challenge and a positive rate of 100% (10/10). Therefore, it was concluded that a 30% aqueous solution of this substance is not sensitizing (US EPA/HPV Challenge program (2005), HSDB (Access on June 2015), ACGIH (7th, 2013)). From the above results, it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government, it was classified as "Classification not possible." As for in vivo, a dominant lethal test in rats gave negative and "ambiguous" results. A micronucleus test using bone marrow cells of mice and rats was negative, and an unscheduled DNA synthesis test in the liver of mice and rats was negative (US EPA Challenge program (2005): ACGIH (7th, 2013)). As for in vitro, a bacterial reverse mutation test, was negative, and a gene mutation test, a chromosomal aberration test, and an unscheduled DNA synthesis test in cultured mammalian cells were positive (NITE Safety test (2009), US EPA Challenge program (2005), ACGIH (7th, 2013)). From the above, although positive results in vitro, because multiple in vivo test systems were negative, it was not judged that Category 2 is appropriate.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, it is written that in a test to detect promoter action in an oral route (drinking water) with this substance (initiated by benzo(a)pyrene), there is a possibility of promoter action because an increased incidence of stomach papilloma was observed in females (no increase in males) (ACGIH (7th, 2013)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a developmental toxicity test in pregnant rats in gavage administration during an organogenetic period (day 6-15 of gestation), developmental toxicity effects were not observed in fetuses even at the doses (393, 568 mg/kg/day) where maternal animals showed weight gain reduction and decreased food consumption. (ACGIH (7th, 2013), U.S. HPV Challenge Program Test Plan (2005)) However, as for fertility effects by this substance, there is only the information from the report of a three-generation test using mice in an inhalation route by combined exposure to nitroethane (ACGIH (7th, 2013)), and no other available data to classify this substance. The classification is not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	There is no human information. As for experimental animals, the following was observed: muscular incoordination and decreased movement in rats and mice in oral administration at 2,150 mg/kg (corresponding to dose above Category 2) (ACGIH (7th, 2013), US EPA/HPV Challenge program (2005)); piloerection and lethargy in a UDS test in rats in oral administration at 2,000 mg/kg (a dose corresponding to Category 2); lethargy and tremors in a micronucleus test in mice in oral administration at 1,500 mg/kg (a dose corresponding to Category 2) (US EPA/HPV Challenge program (2005)); hypoactivity in rats in inhalation exposure to 11.45 mg/L (a dose corresponding to Category 2); and hypersensitivity and incoordination in rabbits in dermal exposure to 1,300 mg/kg (a dose corresponding to Category 2) (ACGIH (7th, 2013), US EPA/HPV Challenge program (2005)). Because hypersensitivity and tremors were observed in the above signs, this substance has effects on the central nervous system. Therefore, it was classified in Category 2 (central nervous system).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There is no human information. As for experimental animals, in a 28-day gavage administration toxicity test using rats (OECD TG 407, GLP), salivation, red eye discharge, red nasal discharge, and red urine were observed at 500 mg/kg/day (converted to a 90-day equivalent: 155.5 mg/kg/day). (NITE Safety Test (2009)) These findings were not effects to be the rationale for classification, and at the dose outside of a range of Category 2. In a 4-week inhalation exposure test using rats (84/449/EEC, B.8), abnormal general conditions accompanying irritation to the upper respiratory tract, dirt coat, eyelid closure, hyperactivity (transient and not a significant change in FOB), walking on tiptoes, hunched posture, weight gain reduction, decreased food consumption, a change in differential leukocyte count (increased segmented neutrophil, decreased lymphocytes), increases in ALP/inorganic phosphorus/bile acid/ALT, decreased absolute/relative thymus weight, increased absolute/relative liver weight, and medullary plasmacytosis in the iliac and popliteal lymph nodes were observed at 1,500 ppm (converted to a Guidance value equivalent: 1.21 mg/L) (US EPA Challenge program (2005), ACGIH (7th, 2013)). These findings were at the dose outside of a range of Category 2 but close to the upper limit (1.0 mg/L). Therefore, it was classified as "Classification not possible" due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From 48-hour EC50 = 110.56 mg/L for crustacea (Daphnia magna) (IUCLID, 2000; HSDB, 2008), it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. Due to being not water-insoluble (water solubility = 89000 mg/L, PHYSPROP Database, 2009), and "Not classified" in acute toxicity, it was classified as "Not classified."	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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